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472 Newest Publications about the topic personalized medicine

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The personal and clinical utility of polygenic risk scores

22-May-2018 | Ali Torkamani; Nathan E. Wineinger; Eric J. Topol, Nature Reviews Genetics, 2018

Initial expectations for genome-wide association studies were high, as such studies promised to rapidly transform personalized medicine with individualized disease risk predictions, prevention strategies and treatments. Early findings, however, revealed a more complex genetic architecture than ...

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Detecting Signatures of Positive Selection along Defined Branches of a Population Tree Using LSD

29-Mar-2018 | Librado P, Orlando L., Molecular Biology and Evolution, 2018

Abstract Identifying the genomic basis underlying local adaptation is paramount to evolutionary biology, and bears many applications in the fields of conservation biology, crop, and animal breeding, as well as personalized medicine. Although many approaches have been developed to detect ...

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Inkjet printing of paracetamol and indomethacin using electromagnetic technology: Rheological compatibility and polymorphic selectivity

12-Mar-2018 | Author(s): Gayathri Kollamaram, Simon C. Hopkins, Bartek A. Glowacki, Denise M. Croker, Gavin M. Walker, European Journal of Pharmaceutical Science, 2018

Publication date: 30 March 2018 Source:European Journal of Pharmaceutical Sciences, Volume 115 Author(s): Gayathri Kollamaram, Simon C. Hopkins, Bartek A. Glowacki, Denise M. Croker, Gavin M. Walker Drop-on-demand inkjet printing is a potential enabling technology both for ...

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Taking personalized medicine to heart

07-Feb-2018 | Nature Medicine, 2018

Taking personalized medicine to heart Taking personalized medicine to heart, Published online: 07 February 2018; doi:10.1038/nm.4495 Tailoring treatment to the individual patient has revolutionized cancer therapy, but personalized medicine has yet to make much headway in the treatment of ...

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Prostate cancer: Race and prostate cancer personalized medicine: the future

16-Jan-2018 | Stephen Freedland, Nature Clinical Practice Urology, 2018

Prostate cancer: Race and prostate cancer personalized medicine: the future Prostate cancer: Race and prostate cancer personalized medicine: the future, Published online: 16 January 2018; doi:10.1038/nrurol.2017.215 Most genetic analyses of prostate cancer have studied white men. A new study ...

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The rocky road to personalized medicine in acute myeloid leukaemia

12-Jan-2018 | Bryan Brinda, Irum Khan, Brian Parkin, Heiko Konig, Journal of Cellular and Molecular Medicine, 2018

Abstract Acute myeloid leukaemia (AML) is a malignant disorder of the myeloid blood lineage characterized by impaired differentiation and increased proliferation of hematopoietic precursor cells. Recent technological advances have led to an improved understanding of AML biology but also ...

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Molecular phenotype of SLC4A11 missense mutants: Setting the stage for personalized medicine in corneal dystrophies

12-Jan-2018 | Kumari Alka, Joseph R. Casey, Human Mutation, 2018

Abstract SLC4A11 mutations cause cases of congenital hereditary endothelial dystrophy (CHED), Harboyan syndrome (HS), and Fuchs endothelial corneal dystrophy (FECD). Defective water reabsorption from corneal stroma by corneal endothelial cells (CECs) leads to these corneal dystrophies. ...

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Insertional mutagenesis in a HER2-positive breast cancer model reveals ERAS as a driver of cancer and therapy resistance

12-Jan-2018 | Gerjon J. Ikink; Mandy Boer; Elvira R. M. Bakker; Annabel Vendel-Zwaagstra; Chris Klijn; Jelle ten Hoeve; Jos Jonker ..., Oncogene, 2018

Personalized medicine for cancer patients requires a deep understanding of the underlying genetics that drive cancer and the subsequent identification of predictive biomarkers. To discover new genes and pathways contributing to oncogenesis and therapy resistance in HER2+ breast cancer, we ...

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Insertional mutagenesis in a HER2-positive breast cancer model reveals ERAS as a driver of cancer and therapy resistance

12-Jan-2018 | Gerjon J. Ikink; Mandy Boer; Elvira R. M. Bakker; Annabel Vendel-Zwaagstra; Chris Klijn; Jelle ten Hoeve; Jos Jonker ..., Oncogene, 2018

Personalized medicine for cancer patients requires a deep understanding of the underlying genetics that drive cancer and the subsequent identification of predictive biomarkers. To discover new genes and pathways contributing to oncogenesis and therapy resistance in HER2+ breast cancer, we ...

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Gut microbiota in 2017: Contribution of gut microbiota–host cooperation to drug efficacy

20-Dec-2017 | Nathalie M. Delzenne; Laure B. Bindels, Nature Clinical Practice Gastroenterology & Hepatology, 2017

Gut microbiota in 2017: Contribution of gut microbiota–host cooperation to drug efficacy Gut microbiota in 2017: Contribution of gut microbiota–host cooperation to drug efficacy, Published online: 20 December 2017; doi:10.1038/nrgastro.2017.170 2017 has witnessed key advances in knowledge about ...

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