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2,793 Newest Publications about the topic pathology

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QnAs with Rafael Radi [QnAs]

26-Jun-2018 | Sandeep Ravindran, Proceedings of the National Academy of Sciences current issue, 2018

Rafael Radi has received numerous awards for his work on free radicals, oxidants, and reduction/oxidation pathways in biomedicine. During a long and fruitful career, he has characterized the formation and chemistry of peroxynitrite, including its role in mitochondrial dysfunction, pathology, and ...

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Differentiated human airway organoids to assess infectivity of emerging influenza virus [Microbiology]

26-Jun-2018 | Jie Zhou; Cun Li; Norman Sachs; Man Chun Chiu; Bosco Ho-Yin Wong; Hin Chu; Vincent Kwok-Man Poon; Dong Wang; Xiaoyu ..., Proceedings of the National Academy of Sciences current issue, 2018

Influenza virus infection represents a major threat to public health worldwide. There is no biologically relevant, reproducible, and readily available in vitro model for predicting the infectivity of influenza viruses in humans. Based on the long-term expanding 3D human airway organoids, we ...

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A molecular mechanism for choosing alcohol over an alternative reward

22-Jun-2018 | Eric Augier; Estelle Barbier; Russell S. Dulman; Valentina Licheri; Gaëlle Augier; Esi Domi; Riccardo Barchiesi; Sea ..., Science , 2018

“Only” about 10 to 15% of people exposed to alcohol develop alcohol-related problems. The behavioral repertoire of people confronted with opportunities to consume alcohol involves numerous choices between this drug reward and healthy alternatives. Augier et al. established a choice procedure that ...

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Receptor networks underpin plant immunity

22-Jun-2018 | Chih-Hang Wu; Lida Derevnina; Sophien Kamoun, Science , 2018

Plants are attacked by a multitude of pathogens and pests, some of which cause epidemics that threaten food security. Yet a fundamental concept in plant pathology is that most plants are actively resistant to most pathogens and pests. Plants fend off their innumerable biotic foes primarily ...

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Fatty acid chemical mediator provides insights into the pathology and treatment of Parkinson’s disease [Neuroscience]

19-Jun-2018 | Cesar V. Borlongan, Proceedings of the National Academy of Sciences current issue, 2018

Parkinson’s disease (PD) ranks as the second-most prevalent neurodegenerative disorder that afflicts the aging population (1). Hallmark neuropathological features of PD consist of dopaminergic cell loss in the substantia nigra, striatal dopamine deficiency, and formation of intracellular ...

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Multi-parametric quantitative MRI reveals three different white matter subtypes

15-Jun-2018 | Jack R. Foucher; Olivier Mainberger; Julien Lamy; Mathieu D. Santin; Alexandre Vignaud; Mathilde M. Roser; Paulo L. ..., PLoS ONE, 2018

by Jack R. Foucher, Olivier Mainberger, Julien Lamy, Mathieu D. Santin, Alexandre Vignaud, Mathilde M. Roser, Paulo L. de Sousa Introduction Magnetic resonance imaging (MRI) shows slight spatial variations in brain white matter (WM). We used quantitative multi-parametric MRI to evaluate in what ...

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Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine [Biochemistry]

05-Jun-2018 | Rafael Radi, Proceedings of the National Academy of Sciences current issue, 2018

Aerobic life in humans imposes the hazard of excess oxidation in cell and tissue components that may compromise cell function and viability. The formation and accumulation of oxidized products in biomolecules such as proteins and lipids are observed in various pathologies and during the normal ...

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Intramolecular energies of the cytotoxic protein CagA of Helicobacter pylori as a possible descriptor of strains’ pathogenicity level

03-Jun-2018 | Author(s): Diana F. Rojas-Rengifo, Maria Camila Alvarez-Silva, Cindy P. Ulloa-Guerrero, Vanessa Lucía Nuñez- ..., Computational Biology and Chemistry, 2018

Publication date: October 2018 Source:Computational Biology and Chemistry, Volume 76 Author(s): Diana F. Rojas-Rengifo, Maria Camila Alvarez-Silva, Cindy P. Ulloa-Guerrero, Vanessa Lucía Nuñez-Velez, Maria del Pilar Delgado, Sonia Milena Aguilera, Harold Castro, Carlos ...

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[Molecular Pathology] Role of the {beta} Common ({beta}c) Family of Cytokines in Health and Disease

01-Jun-2018 | Timothy R. Hercus; Winnie L. T. Kan; Sophie E. Broughton; Denis Tvorogov; Hayley S. Ramshaw; Jarrod J. Sandow; Tracy ..., CSH Perspectives, 2018

The β common ([βc]/CD131) family of cytokines comprises granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3, and IL-5, all of which use βc as their key signaling receptor subunit. This is a prototypic signaling subunit-sharing cytokine family that has unveiled many ...

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Oral administration of Pantoea agglomerans-derived lipopolysaccharide prevents metabolic dysfunction and Alzheimer’s disease-related memory loss in senescence-accelerated prone 8 (SAMP8) mice fed a high-fat diet

01-Jun-2018 | Yutaro Kobayashi; Hiroyuki Inagawa; Chie Kohchi; Kimiko Kazumura; Hiroshi Tsuchiya; Toshiyuki Miwa; Katsuichiro Okaz ..., PLoS ONE, 2018

by Yutaro Kobayashi, Hiroyuki Inagawa, Chie Kohchi, Kimiko Kazumura, Hiroshi Tsuchiya, Toshiyuki Miwa, Katsuichiro Okazaki, Gen-Ichiro Soma The pathogenesis of Alzheimer’s disease (AD) remains unclear, but an imbalance between the production and clearance of amyloid-β (Aβ) peptides is known to ...

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