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1,074 Newest Publications about the topic parkinson's disease

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MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration

21-May-2018 | Eunju Lee; Inhwa Hwang; Sangjun Park; Sujeong Hong; Boreum Hwang; Yoeseph Cho; Junghyun Son; Je-Wook Yu, Cell Death and Differentiation, 2018

Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (SN) and the reduction of dopamine levels in the striatum. Although details of the molecular mechanisms underlying dopaminergic neuronal death in PD remain ...

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DNA-mediated dimerization on a compact sequence signature controls enhancer engagement and regulation by FOXA1

14-Apr-2018 | Wang X, Srivastava Y, Jankowski A, et al., Nucleic Acids Research, 2018

Abstract FOXA1 is a transcription factor capable to bind silenced chromatin to direct context-dependent cell fate conversion. Here, we demonstrate that a compact palindromic DNA element (termed ‘DIV’ for its diverging half-sites) induces the homodimerization of FOXA1 with strongly positive ...

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3D Neuromelanin‐sensitive magnetic resonance imaging of the substantia nigra in Parkinson's disease

17-Jan-2018 | Shweta Prasad, Albert Stezin, Abhishek Lenka, Lija George, Jitender Saini, Ravi Yadav, Pramod Kumar Pal, European Journal of Neurology, 2018

Abstract Background To investigate the diagnostic utility of signal intensity measurement of the substantia nigra pars compacta (SNc) using three dimensional (3D) neuromelanin‐sensitive 31MRI, for discrimination of patients with PD from healthy controls. Methods T1‐weighted ...

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Rasagiline improves polysomnographic sleep parameters in patients with Parkinson's disease: A double‐blind, baseline‐controlled trial

11-Jan-2018 | Wiebke Schrempf, Mareike Fauser, Miriam Wienecke, Sebastian Brown, Antonia Maaß, Christiana Ossig, Karolin Otto, Mor ..., European Journal of Neurology, 2018

Abstract Objective To study the effects of rasagiline on sleep quality in Parkinson's disease (PD) patients with sleep disturbances. Introduction Sleep disorders are common in PD. Rasagiline is widely used in PD patients, but double‐blind polysomnographic trials on its effects on ...

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Rasagiline improves polysomnographic sleep parameters in patients with Parkinson's disease: A double‐blind, baseline‐controlled trial

11-Jan-2018 | Wiebke Schrempf, Mareike Fauser, Miriam Wienecke, Sebastian Brown, Antonia Maaß, Christiana Ossig, Karolin Otto, Mor ..., European Journal of Neurology, 2018

Abstract Objective To study the effects of rasagiline on sleep quality in Parkinson's disease (PD) patients with sleep disturbances. Introduction Sleep disorders are common in PD. Rasagiline is widely used in PD patients, but double‐blind polysomnographic trials on its effects on ...

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Motor subtypes and other risk factors associated with drooling in Parkinson's disease patients

09-Jan-2018 | C. J. Mao, Y. T. Xiong, F. Wang, Y. P. Yang, W. Yuan, C. Zhu, J. Chen, C. F. Liu, Acta Neurologica Scandinavica, 2018

Objective To explore the relationship between motor subtypes and drooling, and other risk factors associated with drooling in a large cohort of Chinese patients with Parkinson's disease (PD). Methods A total of 586 PD patients were enrolled in this study. Unified Parkinson's disease ...

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Vascular risk factors and depression in Parkinson's disease

22-Dec-2017 | Ruwei Ou, Qianqian Wei, Yanbing Hou, Xiaoqin Yuan, Wei Song, Bei Cao, Hui Liu, Lingyu Zhang, Yongping Chen, Huifang ..., European Journal of Neurology, 2017

Abstract Objective This study aims to address the vascular depression hypothesis in Parkinson's disease (PD) from a large cohort of Chinese population. Methods A cross‐sectional analysis of 1784 Chinese patients with PD was conducted. Patients were divided into absence of depression ...

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Running wheel exercise reduces α-synuclein aggregation and improves motor and cognitive function in a transgenic mouse model of Parkinson's disease

22-Dec-2017 | Wenbo Zhou; Jessica Cummiskey Barkow; Curt R. Freed, PLoS ONE, 2017

by Wenbo Zhou, Jessica Cummiskey Barkow, Curt R. Freed Exercise has been recommended to improve motor function in Parkinson patients, but its value in altering progression of disease is unknown. In this study, we examined the neuroprotective effects of running wheel exercise in mice. In adult ...

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Author Correction: Synuclein and dopamine: the Bonnie and Clyde of Parkinson's disease

20-Dec-2017 | Subhojit Roy, Nature Neuroscience, 2017

Author Correction: Synuclein and dopamine: the Bonnie and Clyde of Parkinson's disease Author Correction: Synuclein and dopamine: the Bonnie and Clyde of Parkinson's disease, Published online: 20 December 2017; doi:10.1038/s41593-017-0035-7 Author Correction: Synuclein and dopamine: the Bonnie ...

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Changes in neuronal activity of cortico‐basal ganglia‐thalamic networks induced by acute dopaminergic manipulations in rats

18-Dec-2017 | Nedjeljka Ivica, Ulrike Richter, Joel Sjöbom, Ivani Brys, Martin Tamtè, Per Petersson, European Journal of Neuroscience, 2017

Abstract The basal ganglia are thought to be particularly sensitive to changes in dopaminergic tone, and the realization that reduced dopaminergic signaling causes pronounced motor dysfunction is the rationale behind dopamine replacement therapy in Parkinson's disease. It has however proven ...

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