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746 Newest Publications about the topic neurodegenerative disorders


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Keeping stress granules in check

01-Jun-2018 | Sacha Vignieri; Jesse Smith; Stella M. Hurtley, Science , 2018

Neurodegeneration Stress granules are membraneless organelles composed of RNAs and proteins that can accumulate in the presence of potentially pathogenic proteins. These include proteins linked to neurodegenerative disorders such as C9-ALS/FTD (amyotrophic lateral sclerosis and frontotemporal


Neurodegenerative disorders: Rescuing mitochondrial motility

18-May-2018 | Sarah Crunkhorn, Nature Reviews Drug Discovery, 2018

Neurodegenerative disorders: Rescuing mitochondrial motility Neurodegenerative disorders: Rescuing mitochondrial motility, Published online: 18 May 2018; doi:10.1038/nrd.2018.76 Neurodegenerative disorders: Rescuing mitochondrial motility


Multivariate meta-analyses of mitochondrial complex I and IV in major depressive disorder, bipolar disorder, schizophrenia, Alzheimer disease, and Parkinson disease

16-May-2018 | L Holper; D Ben-Shachar; JJ Mann, Neuropsychopharmacology, 2018

Complex I (NADH dehydrogenase, NDU) and complex IV (cytochrome-c-oxidase, COX) of the mitochondrial electron transport chain have been implicated in the pathophysiology of major psychiatric disorders, such as major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ), as well ...


Clinical and genetic spectrum of AMPD2-related pontocerebellar hypoplasia type 9

20-Feb-2018 | Fanny Kortüm; Rami Abou Jamra; Malik Alawi; Susan A. Berry; Guntram Borck; Katherine L. Helbig; Sha Tang; Dagma ..., European Journal of Human Genetics, 2018

Pontocerebellar hypoplasia (PCH) represents a group of autosomal-recessive progressive neurodegenerative disorders of prenatal onset. Eleven PCH subtypes are classified according to clinical, neuroimaging and genetic findings. Individuals with PCH type 9 (PCH9) have a unique combination of ...


Exploring the genetics and non-cell autonomous mechanisms underlying ALS/FTLD

19-Feb-2018 | Hongbo Chen; Mark W. Kankel; Susan C. Su; Steve W. S. Han; Dimitry Ofengeim, Cell Death and Differentiation, 2018

Although amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, was first described in 1874, a flurry of genetic discoveries in the last 10 years has markedly increased our understanding of this disease. These findings have not only enhanced our knowledge of mechanisms leading ...


Morgan Sheng

19-Jan-2018 | Nature Reviews Drug Discovery, 2018

Morgan Sheng Morgan Sheng, Published online: 19 January 2018; doi:10.1038/nrd.2017.271 Morgan Sheng, Vice President of Neuroscience at Genentech, discusses his continued faith in the amyloid hypothesis, the promise of the genetics of neurodegenerative disorders and the overlap between ...


The role of microbial amyloid in neurodegeneration

21-Dec-2017 | Robert P. Friedland; Matthew R. Chapman, PLoS Pathogens, 2017

by Robert P. Friedland, Matthew R. Chapman It has become apparent that the intestinal microbiota orchestrates important aspects of our metabolism, immunity, and development. Recent work has demonstrated that the microbiota also influences brain function in healthy and diseased individuals. Of ...


Evidence for effective structure‐based neuromodulatory effects of new analogs of neurosteroid allopregnanolone

19-Dec-2017 | Omar Taleb, Christine Patte‐Mensah, Laurence Meyer, Véronique Kemmel, Philippe Geoffroy, Michel Miesch, Ayikoe‐Guy M ..., Journal of Neuroendocrinology, 2017

Abstract The neurosteroid allopregnanolone (AP) modulates neuroendocrine/neurobiological processes, including hypothalamic–pituitary–adrenocortical activities, pain, anxiety, neurogenesis and neuroprotection. These observations raised the hope to develop AP‐based therapies against ...


Structural basis of membrane disruption and cellular toxicity by {alpha}-synuclein oligomers

15-Dec-2017 | Giuliana Fusco; Serene W. Chen; Philip T. F. Williamson; Roberta Cascella; Michele Perni; James A. Jarvis; Cristina ..., Science , 2017

Oligomeric species populated during the aggregation process of α-synuclein have been linked to neuronal impairment in Parkinson’s disease and related neurodegenerative disorders. By using solution and solid-state nuclear magnetic resonance techniques in conjunction with other structural methods, ...


Long-term dopamine neurochemical monitoring in primates [Engineering]

12-Dec-2017 | Helen N. Schwerdt; Hideki Shimazu; Ken-ichi Amemori; Satoko Amemori; Patrick L. Tierney; Daniel J. Gibson; Simon Hon ..., Proceedings of the National Academy of Sciences current issue, 2017

Many debilitating neuropsychiatric and neurodegenerative disorders are characterized by dopamine neurotransmitter dysregulation. Monitoring subsecond dopamine release accurately and for extended, clinically relevant timescales is a critical unmet need. Especially valuable has been the development ...


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