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203 Newest Publications about the topic neck cancer


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Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes [Medical Sciences]

12-Jun-2018 | Julie P. Saiki; Hongbin Cao; Lauren D. Van Wassenhove; Vignesh Viswanathan; Joshua Bloomstein; Dhanya K. Nambiar; Aa ..., Proceedings of the National Academy of Sciences current issue, 2018

Radiation therapy for head and neck cancer often leads to dry mouth, a debilitating condition that affects speaking, swallowing, and other functions related to quality of life. Since salivary functional recovery after radiation is largely dependent on the number of surviving salivary ...


Adjuvant chemotherapy with S-1 after curative chemoradiotherapy in patients with locoregionally advanced squamous cell carcinoma of the head and neck: Reanalysis of the ACTS-HNC study

08-Jun-2018 | Akira Kubota; Eiji Nakatani; Kiyoaki Tsukahara; Yasuhisa Hasegawa; Hideki Takemura; Tomonori Terada; Takahide Taguch ..., PLoS ONE, 2018

by Akira Kubota, Eiji Nakatani, Kiyoaki Tsukahara, Yasuhisa Hasegawa, Hideki Takemura, Tomonori Terada, Takahide Taguchi, Kunihiko Nagahara, Hiroaki Nakatani, Kunitoshi Yoshino, Yuichiro Higaki, Shigemichi Iwae, Takeshi Beppu, Yutaka Hanamure, Kichinobu Tomita, Naoyuki Kohno, Kazuyoshi Kawabata, ...


Adenovirus-mediated transfer of HPV 16 E6/E7 antisense RNA combined with cisplatin inhibits cellular growth and induces apoptosis in HPV-positive head and neck cancer cells

24-May-2018 | Yasutaka Kojima; Naoki Otsuki; Mie Kubo; Junko Kitamoto; Eri Takata; Hiroki Saito; Kyoko Kosaka; Naoya Morishita; Na ..., Cancer Gene Therapy, 2018

Human papillomavirus (HPV) infection has been identified as an etiologic factor of head and neck cancers (HNCs). We explored the potential use of antisense HPV RNA transcripts for gene therapy and its effect in combination with cisplatin (CDDP) for HPV-positive HNCs. We introduced the antisense ...


The molecular landscape of head and neck cancer

02-Mar-2018 | C. René Leemans; Peter J. F. Snijders; Ruud H. Brakenhoff, Nature Reviews Cancer, 2018

The molecular landscape of head and neck cancer The molecular landscape of head and neck cancer, Published online: 02 March 2018; doi:10.1038/nrc.2018.11 Head and neck cancer is an unexpectedly heterogeneous disease. In this Review, Leemans, Snijders and Brakenhoff provide an update on the ...


Salivary glands regenerate after radiation injury through SOX2‐mediated secretory cell replacement

15-Jan-2018 | Elaine Emmerson, Alison J May, Lionel Berthoin, Noel Cruz‐Pacheco, Sara Nathan, Aaron J Mattingly, Jolie L Chang, Wi ..., EMBO Molecular Medicine, 2018

Abstract Salivary gland acinar cells are routinely destroyed during radiation treatment for head and neck cancer that results in a lifetime of hyposalivation and co‐morbidities. A potential regenerative strategy for replacing injured tissue is the reactivation of endogenous stem cells by ...


Splice Expression Variation Analysis (SEVA) for inter-tumor heterogeneity of gene isoform usage in cancer

12-Jan-2018 | Afsari B, Guo T, Considine M, et al., Bioinformatics, 2018

Abstract Motivation Current bioinformatics methods to detect changes in gene isoform usage in distinct phenotypes compare the relative expected isoform usage in phenotypes. These statistics model differences in isoform usage in normal tissues, which have stable regulation of gene splicing. ...


Rapid nodal staging of head and neck cancer surgical specimens with flow cytometric analysis

21-Nov-2017 | Åsa Kågedal; Cecilia Drakskog; Eric Hjalmarsson; Eva Munck-Wikland; Gregori Margolin; Lars Olaf Cardell; O ..., British Journal of Cancer, 2017

Rapid nodal staging of head and neck cancer surgical specimens with flow cytometric analysis Rapid nodal staging of head and neck cancer surgical specimens with flow cytometric analysis, Published online: 21 November 2017; doi:10.1038/bjc.2017.408 Rapid nodal staging of head and neck cancer ...


In vitro investigation of head and neck cancer stem cell proportions and their changes following X-ray irradiation as a function of HPV status

13-Oct-2017 | Paul Reid; Puthenparampil Wilson; Yanrui Li; Loredana G. Marcu; Alexander H. Staudacher; Michael P. Brown; Eva Bezak, PLoS ONE, 2017

by Paul Reid, Puthenparampil Wilson, Yanrui Li, Loredana G. Marcu, Alexander H. Staudacher, Michael P. Brown, Eva Bezak Introduction Some head and neck squamous cell carcinomas (HNSCC) have a distinct aetiology, which depends on the presence of oncogenic human papilloma virus (HPV). Also, HNSCC ...


Mass Spectrometric Analysis of SOX11-Binding Proteins in Head and Neck Cancer Cells Demonstrates the Interaction of SOX11 and HSP90α

02-Oct-2017 | Naseim Elzakra; Li Cui; Tong Liu; Hong Li; Junwei Huang; Shen Hu, Journal of Proteome Research, 2017

Deregulated expression of SOX11 has been shown to be involved in the progression of various types of cancer. However, the role of SOX11 in head and neck cancer remains largely unknown. In this study, coimmunoprecipitation (Co-IP) and liquid chromatography–tandem mass spectrometry (LC–MS/MS) were ...


Mussel-inspired PLGA/polydopamine core-shell nanoparticle for light induced cancer thermochemotherapy

06-Aug-2017 | Author(s): Huacheng He, Eleni Markoutsa, Yihong Zhan, Jiajia Zhang, Peisheng Xu, Acta Biomaterialia, 2017

Publication date: 1 September 2017 Source:Acta Biomaterialia, Volume 59 Author(s): Huacheng He, Eleni Markoutsa, Yihong Zhan, Jiajia Zhang, Peisheng Xu Most photothermal converting systems are not biodegradable, which bring the uneasiness when they are administered into human body ...


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