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12,531 Newest Publications about the topic mutations

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Role of the novel endoribonuclease SLFN14 and its disease-causing mutations in ribosomal degradation [ARTICLE]

01-Jul-2018 | Sarah J. Fletcher; Vera P. Pisareva; Abdullah O. Khan; Andrew Tcherepanov; Neil V. Morgan; Andrey V. Pisarev, RNA, 2018

Platelets are anucleate and mostly ribosome-free cells within the bloodstream, derived from megakaryocytes within bone marrow and crucial for cessation of bleeding at sites of injury. Inherited thrombocytopenias are a group of disorders characterized by a low platelet count and are frequently ...

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Viruses, Vol. 10, Pages 352: HSV as A Platform for the Generation of Retargeted, Armed, and Reporter-Expressing Oncolytic Viruses

30-Jun-2018 | Menotti, Laura ; Avitabile, Elisa ; Gatta, Valentina ; Malatesta, Paolo ; Petrovic, Biljana ; Campadelli-Fiume, Gabr ..., Viruses, 2018

Viruses, Vol. 10, Pages 352: HSV as A Platform for the Generation of Retargeted, Armed, and Reporter-Expressing Oncolytic Viruses Viruses doi: 10.3390/v10070352 Authors: Laura Menotti Elisa Avitabile Valentina Gatta Paolo Malatesta Biljana Petrovic Gabriella ...

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Viruses, Vol. 10, Pages 351: Resistance Development to Bacteriophages Occurring during Bacteriophage Therapy

30-Jun-2018 | Oechslin, Frank, Viruses, 2018

Viruses, Vol. 10, Pages 351: Resistance Development to Bacteriophages Occurring during Bacteriophage Therapy Viruses doi: 10.3390/v10070351 Authors: Frank Oechslin Bacteriophage (phage) therapy, i.e., the use of viruses that infect bacteria as antimicrobial agents, is a promising ...

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Blood test may predict cancer immunotherapy benefit

29-Jun-2018 | Ken Garber, Science , 2018

Some cancers generate the seeds of their own destruction. Ten years ago, researchers discovered that certain random mutations that accumulate in rapidly dividing tumor cells can spur the immune system to attack the cancer. Lately, researchers have found that the extent of such mutations can ...

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Is cancer a breakdown of multicellularity?

29-Jun-2018 | Elizabeth Pennisi, Science , 2018

A decade ago, a radical theory of cancer emerged: that this plague of multicellular organisms arises when multicellularity breaks down, and cells start acting as if they were on their own. Recently computational cancer biologists examined gene expression in seven types of solid cancers and traced ...

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Two critical positions in zinc finger domains are heavily mutated in three human cancer types

28-Jun-2018 | Daniel Munro; Dario Ghersi; Mona Singh, PLoS Computational Biology, 2018

by Daniel Munro, Dario Ghersi, Mona Singh A major goal of cancer genomics is to identify somatic mutations that play a role in tumor initiation or progression. Somatic mutations within transcription factors are of particular interest, as gene expression dysregulation is widespread in cancers. ...

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Within-patient mutation frequencies reveal fitness costs of CpG dinucleotides and drastic amino acid changes in HIV

28-Jun-2018 | Kristof Theys; Alison F. Feder; Maoz Gelbart; Marion Hartl; Adi Stern; Pleuni S. Pennings, PLoS Genetics, 2018

by Kristof Theys, Alison F. Feder, Maoz Gelbart, Marion Hartl, Adi Stern, Pleuni S. Pennings HIV has a high mutation rate, which contributes to its ability to evolve quickly. However, we know little about the fitness costs of individual HIV mutations in vivo, their distribution and the ...

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CHD4 and the NuRD complex directly control cardiac sarcomere formation [Developmental Biology]

26-Jun-2018 | Caralynn M. Wilczewski; Austin J. Hepperla; Takashi Shimbo; Lauren Wasson; Zachary L. Robbe; Ian J. Davis; Paul A. W ..., Proceedings of the National Academy of Sciences current issue, 2018

Birth defects are the leading cause of infant mortality in the United States and Europe, with cardiac defects being the most prevalent. Here we define the requirement and mechanism of action of CHD4, the catalytic core component of the nucleosome remodeling and deacetylase (NuRD) complex, in ...

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On the role of sidechain size and charge in the aggregation of A{beta}42 with familial mutations [Biophysics and Computational Biology]

26-Jun-2018 | Xiaoting Yang; Georg Meisl; Birgitta Frohm; Eva Thulin; Tuomas P. J. Knowles; Sara Linse, Proceedings of the National Academy of Sciences current issue, 2018

The aggregation of the amyloid-β (Aβ) peptide into amyloid fibrils is associated with Alzheimer’s disease, and several point mutations leading to early-onset disease have been identified in Aβ. By studying the aggregation of five disease-related mutations in vitro, we rationalize their link to ...

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Cancer-mutation network and the number and specificity of driver mutations [Medical Sciences]

26-Jun-2018 | Jaime Iranzo; Iñigo Martincorena; Eugene V. Koonin, Proceedings of the National Academy of Sciences current issue, 2018

Cancer genomics yields a wealth of information on cancer-associated mutations in various cancer types, but current understanding of the number and tissue specificity of the driver mutations remains limited. We applied mathematical methods for network analysis to identify distinct modules linking ...

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