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270 Newest Publications about the topic molecular imaging

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Does nonmetastatic castration-resistant prostate cancer still exist?

23-Apr-2018 | Celestia S. Higano, Nature Clinical Practice Oncology, 2018

Does nonmetastatic castration-resistant prostate cancer still exist? Does nonmetastatic castration-resistant prostate cancer still exist?, Published online: 23 April 2018; doi:10.1038/s41571-018-0025-z After almost 20 years of negative trials of novel therapies for patients with nonmetastatic ...

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Recent progress in photoacoustic molecular imaging

15-Apr-2018 | Author(s): Junjie Yao, Lihong V Wang, Current Opinion in Chemical Biology, 2018

Publication date: August 2018 Source:Current Opinion in Chemical Biology, Volume 45 Author(s): Junjie Yao, Lihong V Wang By acoustically detecting the optical absorption contrast, photoacoustic (PA) tomography (PAT) has broken the penetration limits of traditional high-resolution ...

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PET Radiometals for Antibody Labeling

17-Jan-2018 | Eduardo Aluicio‐Sarduy, Paul A. Ellison, Todd E. Barnhart, Weibo Cai, Robert Jerry Nickles, Jonathan W. Engle, Journal of Labelled Compounds and Radiopharmaceuticals, 2018

Recent advances in molecular characterization of tumors have made possible the emergence of new types of cancer therapies where the traditional cytotoxic drugs and nonspecific chemotherapy can be complemented with targeted molecular therapies. One of the main revolutionary treatments is the use ...

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Condensin is a highly processive DNA motor

03-Nov-2017 | Stella Hurtley; Steve Mao, Science , 2017

Molecular Imaging Condensin is thought to regulate genome architecture by creating DNA loops. Terakawa et al. used single-molecule imaging to show that yeast condensin is a highly processive mechanochemical motor capable of translocating along DNA (see the Perspective by Nasmyth). Their findings

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Synthesis and Assessment of Peptide Gd–DOTA Conjugates Targeting Extradomain B Fibronectin for Magnetic Resonance Molecular Imaging of Prostate Cancer

25-Oct-2017 | Yajuan Li; Zheng Han; Sarah Roelle; Aidan DeSanto; Rob Sabatelle; Rebecca Schur; Zheng-Rong Lu, Molecular Pharmaceutics, 2017

Contrast enhanced MRI is commonly used in imaging and treatment planning of prostate cancer. However, no tumor targeting contrast agent is commercially available for accurate detection and characterization of prostate cancer with MRI. Extradomain B fibronectin (EDB-FN), an oncoprotein present in ...

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Synthesis and Assessment of Peptide Gd–DOTA Conjugates Targeting Extradomain B Fibronectin for Magnetic Resonance Molecular Imaging of Prostate Cancer

25-Oct-2017 | Yajuan Li; Zheng Han; Sarah Roelle; Aidan DeSanto; Rob Sabatelle; Rebecca Schur; Zheng-Rong Lu, Molecular Pharmaceutics, 2017

Contrast enhanced MRI is commonly used in imaging and treatment planning of prostate cancer. However, no tumor targeting contrast agent is commercially available for accurate detection and characterization of prostate cancer with MRI. Extradomain B fibronectin (EDB-FN), an oncoprotein present in ...

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Nuclear and Fluorescent Labeled PD-1-Liposome-DOX-64Cu/IRDye800CW Allows Improved Breast Tumor Targeted Imaging and Therapy

19-Oct-2017 | Yang Du; Xiaolong Liang; Yuan Li; Ting Sun; Zhengyu Jin; Huadan Xue; Jie Tian, Molecular Pharmaceutics, 2017

The overexpression of programmed cell death-1 (PD-1) in tumors as breast cancer makes it a possible target for cancer imaging and therapy. Advances in molecular imaging, including radionuclide imaging and near-infrared fluorescence (NIRF) imaging, enable the detection of tumors with high ...

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Monitoring inflammation injuries in the progression of atherosclerosis with contrast enhanced ultrasound molecular imaging

05-Oct-2017 | Ruiying Sun; Jie Tian; Jun Zhang; Liping Wang; Jing Guo; Yani Liu, PLoS ONE, 2017

by Ruiying Sun, Jie Tian, Jun Zhang, Liping Wang, Jing Guo, Yani Liu Purpose The upregulation of vascular cell adhesion molecule-1(VCAM-1) on vascular endothelium plays a great role in the progression of atherosclerosis (AS). In this study, ultrasound molecular imaging was performed to monitor ...

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Molecular Imaging of P-glycoprotein in Chemoresistant Tumors Using a Dual-Modality PET/Fluorescence Probe

30-Aug-2017 | Mengzhe Wang; Chengqiong Mao; Hui Wang; Xueying Ling; Zhanhong Wu; Zibo Li; Xin Ming, Molecular Pharmaceutics, 2017

Overexpression of P-glycoprotein (Pgp) has been considered a primary cause for multidrug resistance in a variety of cancers for three decades. However, clinical translation of Pgp targeted therapeutics has been hindered by lack of patient preselection based on the Pgp presence in tumors. We aim ...

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Ursolic Acid, A Natural Nutraceutical Agent, Targets Caspase3 and Alleviates Inflammation‐Associated Downstream Signal Transduction

12-Aug-2017 | Xiaoyao Ma, Yuan Zhang, Zengyong Wang, Yunbing Shen, Man Zhang, Quandeng Nie, Yuanyuan Hou, Gang Bai, Molecular Nutrition & Food Research, 2017

Scope Ursolic acid (UA) is a pentacyclicterpenoid carboxylic acid that is present in a wide variety of plant foods. There are many beneficial health effects that are attributed to the properties of UA. However, the specific cellular targets of UA and the mechanism underlying downstream signal ...

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