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1,802 Newest Publications about the topic molecular biology

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Assembly of the small ribosomal subunit in yeast: mechanism and regulation [REVIEW]

01-Jul-2018 | Malik Chaker-Margot, RNA, 2018

The eukaryotic ribosome is made of four intricately folded ribosomal RNAs and 79 proteins. During rapid growth, yeast cells produce an incredible 2000 ribosomes every minute. Ribosome assembly involves more than 200 trans-acting factors, intervening from the transcription of the preribosomal RNA ...

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Inactivating sex chromosomes

29-Jun-2018 | Caroline Ash; Jesse Smith; Steve Mao, Science , 2018

Molecular Biology To compensate for sex chromosome dosage, XX females undergo epigenetic inactivation (XCI) of one X chromosome. Using a mouse embryonic stem cell culture system, Sousa et al. investigated this process in vitro. Surprisingly, they found that male cells also undergo XCI, albeit

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Structural basis for spliceosome assembly

29-Jun-2018 | Caroline Ash; Steve Mao, Science , 2018

Molecular Biology The spliceosome removes noncoding sequences from precursor RNA and ligates coding sequences into useful mRNA. The pre-spliceosome (A complex) associates with a small nuclear ribonucleoprotein (snRNP) complex called U4/U6.U5 tri-snRNP to form the pre-B complex, which is converted

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Viruses, Vol. 10, Pages 316: Non-Primate Lentiviral Vectors and Their Applications in Gene Therapy for Ocular Disorders

09-Jun-2018 | Cavalieri, Vincenzo ; Baiamonte, Elena ; Lo Iacono, Melania, Viruses, 2018

Viruses, Vol. 10, Pages 316: Non-Primate Lentiviral Vectors and Their Applications in Gene Therapy for Ocular Disorders Viruses doi: 10.3390/v10060316 Authors: Vincenzo Cavalieri Elena Baiamonte Melania Lo Iacono Lentiviruses have a number of molecular features in common, ...

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The long and short of RNA export

08-Jun-2018 | Sacha Vignieri; Jesse Smith; Steve Mao, Science , 2018

Molecular Biology Circular RNAs (circRNAs) are back-spliced RNA products that have regulatory roles in gene expression, and most circRNAs are enriched in the cytoplasm. Huang et al. identified protein factors that are required to export circRNAs from the nucleus to the cytoplasm. An RNA ...

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[Molecular Biology] Circadian Posttranscriptional Regulatory Mechanisms in Mammals

01-Jun-2018 | Carla B. Green, CSH Perspectives, 2018

The circadian clock drives rhythms in the levels of thousands of proteins in the mammalian cell, arising in part from rhythmic transcriptional regulation of the genes that encode them. However, recent evidence has shown that posttranscriptional processes also play a major role in generating the ...

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[Molecular Biology] Cytokines and Long Noncoding RNAs

01-Jun-2018 | Susan Carpenter; Katherine A. Fitzgerald, CSH Perspectives, 2018

Cytokines and long noncoding RNAs (lncRNAs) are intertwined in the regulatory circuit controlling immunity. lncRNA expression levels are altered following cytokine stimulation in a cell-type-specific fashion. lncRNAs, in turn, regulate the inducible expression of cytokines following immune ...

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[Molecular Biology] Therapeutic Opportunities in Eukaryotic Translation

01-Jun-2018 | Jennifer Chu; Jerry Pelletier, CSH Perspectives, 2018

The ability to block biological processes with selective small molecules provides advantages distinct from most other experimental approaches. These include rapid time to onset, swift reversibility, ability to probe activities in manners that cannot be accessed by genetic means, and the potential ...

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RNA and membraneless organelles

25-May-2018 | Stella Hurtley; Steve Mao, Science , 2018

Molecular Biology Membraneless compartments can form in cells through liquid-liquid phase separation (see the Perspective by Polymenidou). But what prevents these cellular condensates from randomly fusing together? Using the RNA-binding protein (RBP) Whi3, Langdon et al. demonstrated that the

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Viruses, Vol. 10, Pages 285: Hepatitis E in High-Income Countries: What Do We Know? And What Are the Knowledge Gaps?

25-May-2018 | Capai, Lisandru ; Charrel, Rémi ; Falchi, Alessandra, Viruses, 2018

Viruses, Vol. 10, Pages 285: Hepatitis E in High-Income Countries: What Do We Know? And What Are the Knowledge Gaps? Viruses doi: 10.3390/v10060285 Authors: Lisandru Capai Rémi Charrel Alessandra Falchi Hepatitis E virus (HEV) is a positive-strand RNA virus transmitted by the ...

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