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23 Newest Publications about the topic membrane filters

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Optimization of a biotechnological multiproduct batch plant design for the manufacture of four different products: a real case scenario

01-Feb-2017 | G. Sandoval, D. Espinoza, N. Figueroa, J.A. Asenjo, Biotechnology and Bioengineering, 2017

Abstract In this work a biotechnological multiproduct batch plant that manufactures four different recombinant proteins for human application is described in some detail. This batch plant design is then optimized with regards to the size of equipment using a mixed‐integer linear programming ...

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Development of Downstream Processing to Minimise Beta‐Glucan Impurities in GMP‐Manufactured Therapeutic Antibodies

08-Sep-2016 | Kim Vigor, John Emerson, Robert Scott, Julia Cheek, Claire Barton, Heather J. Bax, Debra H. Josephs, Sophia N. Karag ..., Biotechnology Progress, 2016

Abstract The presence of impurities or contaminants in biological products such as monoclonal antibodies (mAb) could affect efficacy or cause adverse reactions in patients. ICH guidelines (Q6A and Q6B) are in place to regulate the level of impurities within clinical drug products. An impurity ...

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Changes in glucose fermentation pathways by an enriched bacterial culture in response to regulated dissolved H2 concentrations

29-Dec-2014 | Hang Zheng, Raymond J. Zeng, Mikel C. Duke, Cathryn A O'Sullivan, William P. Clarke, Biotechnology and Bioengineering, 2014

Abstract It is well established that metabolic pathways in the fermentation of organic waste are primarily controlled by dissolved H2 concentrations, but there is no reported study that compares observed and predicted shifts in fermentation pathways induced by manipulating the dissolved H2 ...

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Multipronged approach to managing beta‐glucan contaminants in the downstream process: Control of raw materials and filtration with charge‐modified nylon 6,6 membrane filters

18-Apr-2013 | Eva Gefroh, Art Hewig, Ganesh Vedantham, Megan McClure, Alla Krivosheyeva, Ajay Lajmi, Yuefeng Lu, Biotechnology Progress, 2013

(1→3)‐β‐d‐Glucans (beta‐glucans) have been found in raw materials used in the manufacture of recombinant therapeutics. Because of their biological activity, beta‐glucans are considered process contaminants and consequently their level in the product needs to be controlled. Although beta‐glucans ...

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Evaluation and Implementation of a Membrane Filter Method for Cronobacter Detection in Drinking Water

11-Apr-2013 | Hui Liu, Yuelian Yang, Jinghua Cui, Lanzheng Liu, Huiyuan Liu, Guangchun Hu, Yuwen Shi, Jian Li, FEMS Microbiology Letters, 2013

Abstract A membrane filter (MF) method was evaluated for its suitability for qualitative and quantitative analyses of Cronobacter spp. in drinking water by pure strains of Cronobacter and non‐Cronobacter, and samples spiked with chlorinated Cronobacter sakazakii ATCC 29544. The applicability ...

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Multi‐pronged approach to managing beta‐glucan contaminants in the downstream process: Control of raw materials and filtration with charge‐modified nylon 6, 6 membrane filters

06-Mar-2013 | Eva Gefroh, Art Hewig, Ganesh Vedantham, Megan McClure, Alla Krivosheyeva, Ajay Lajmi|, Yuefeng Lu, Biotechnology Progress, 2013

Abstract (1→3)‐β‐D‐glucans (beta‐glucans) have been found in raw materials used in the manufacture of recombinant therapeutics. Because of their biological activity, beta‐glucans are considered process contaminants and consequently their level in the product needs to be controlled. While ...

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Methods for Primary Concentration of Viruses from Water Samples: A Review and Meta‐Analysis of Recent Studies

29-Jan-2013 | Jennifer L. Cashdollar, Larry Wymer, Journal of Applied Microbiology, 2013

Abstract Since the beginning of environmental virology in the mid‐20th century, a key challenge to scientists in the environmental field has been how to collect, isolate, and detect pathogenic viruses from water that is used for drinking and/or recreational purposes. Early studies investigated ...

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Enhancing robustness for speech recognition through bio-inspired auditory filter-bank

19-Oct-2012 | Hari Krishna Maganti; Marco Matassoni, International Journal of Bio-Inspired Computation, 2012

Enhancing robustness for speech recognition through bio-inspired auditory filter-bankHari Krishna Maganti; Marco MatassoniInternational Journal of Bio-Inspired Computation, Vol. 4, No. 5 (2012) pp. 271 - 277One of the important properties observed in basilar membrane filtering, aimed to improve ...

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Persistent DNA Damage Measured by Comet Assay of Sprague Dawley Rat Lung Cells after Five Days of Inhalation Exposure and 1 Month Post-Exposure to Dispersed Multi-Wall Carbon Nanotubes (MWCNTs) Generated by New MWCNT Aerosol Generation System

01-Aug-2012 | Jin Sik Kim; Jae Huyck Sung; Kyung Seuk Song; Ji Hyun Lee; Sun Man Kim; Gun Ho Lee; Kang Ho Ahn; Jong Seong Lee; Jae ..., Toxicological Sciences, 2012

Carbon nanotubes (CNTs) have specific physico-chemical properties that are useful for the electronics, automotive, and construction industries. Yet, despite their many advantages, there is a current lack of available information on the human health and environmental hazards of CNTs. For this ...

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Particles shed from syringe filters and their effects on agitation‐induced protein aggregation

06-Jun-2012 | Lu Liu, Theodore W. Randolph, John F. Carpenter, Journal of Pharmaceutical Sciences, 2012

Abstract We tested the hypothesis that foreign particles shed from filters can accelerate the rate of protein aggregation and particle formation during agitation stress. Various types and brands of syringe filters were tested. Particle counts and size distribution (≥1 µm) in buffer alone or in ...

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