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1,486 Newest Publications about the topic melanoma

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Innate immune sensor LGP2 is cleaved by the Leader protease of foot-and-mouth disease virus

29-Jun-2018 | Miguel Rodríguez Pulido; María Teresa Sánchez-Aparicio; Encarnación Martínez-Salas; Adolfo García-Sastre; Francisco ..., PLoS Pathogens, 2018

by Miguel Rodríguez Pulido, María Teresa Sánchez-Aparicio, Encarnación Martínez-Salas, Adolfo García-Sastre, Francisco Sobrino, Margarita Sáiz The RNA helicase LGP2 (Laboratory of Genetics and Physiology 2) is a non-signaling member of the retinoic acid-inducible gene-I (RIG-I)-like receptors ...

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Enhancing radiosensitivity of melanoma cells through very high dose rate pulses released by a plasma focus device

29-Jun-2018 | Francesca Buontempo; Ester Orsini; Isabella Zironi; Lorenzo Isolan; Alessandra Cappellini; Stefania Rapino; Agostino ..., PLoS ONE, 2018

by Francesca Buontempo, Ester Orsini, Isabella Zironi, Lorenzo Isolan, Alessandra Cappellini, Stefania Rapino, Agostino Tartari, Domiziano Mostacci, Giorgio Cucchi, Alberto Maria Martelli, Marco Sumini, Gastone Castellani Radiation therapy is a useful and standard tumor treatment strategy. ...

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PHIP as a therapeutic target for driver-negative subtypes of melanoma, breast, and lung cancer [Medical Sciences]

19-Jun-2018 | David de Semir; Vladimir Bezrookove; Mehdi Nosrati; Altaf A. Dar; Clayton Wu; Julia Shen; Christopher Rieken; Meenak ..., Proceedings of the National Academy of Sciences current issue, 2018

The development of targeted therapies represents a major advance in cancer therapy, with its most prominent examples including agents targeting HER2 in breast cancer, EGFR and ALK in lung cancer, and BRAF in melanoma. However, a key challenge confronting such precision medicine approaches ...

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Viruses, Vol. 10, Pages 312: Comparison of Porcine Airway and Intestinal Epithelial Cell Lines for the Susceptibility and Expression of Pattern Recognition Receptors upon Influenza Virus Infection

07-Jun-2018 | Thomas, Milton ; Pierson, Max ; Uprety, Tirth ; Zhu, Laihua ; Ran, Zhiguang ; Sreenivasan, Chithra C.; Wang, Dan ; ..., Viruses, 2018

Viruses, Vol. 10, Pages 312: Comparison of Porcine Airway and Intestinal Epithelial Cell Lines for the Susceptibility and Expression of Pattern Recognition Receptors upon Influenza Virus Infection Viruses doi: 10.3390/v10060312 Authors: Milton Thomas Max Pierson Tirth Uprety Laihua ...

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Pharmaceuticals, Vol. 11, Pages 58: TRPM Family Channels in Cancer

07-Jun-2018 | Hantute-Ghesquier, Aline ; Haustrate, Aurélien ; Prevarskaya, Natalia ; Lehen’kyi, V’yacheslav, Pharmaceuticals, 2018

Pharmaceuticals, Vol. 11, Pages 58: TRPM Family Channels in Cancer Pharmaceuticals doi: 10.3390/ph11020058 Authors: Aline Hantute-Ghesquier Aurélien Haustrate Natalia Prevarskaya V’yacheslav Lehen’kyi Members of the TRPM (“Melastatin”) family fall into the ...

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Myeloid-restricted ablation of Shp2 restrains melanoma growth by amplifying the reciprocal promotion of CXCL9 and IFN-γ production in tumor microenvironment

24-May-2018 | P. Xiao; Y. Guo; H. Zhang; X. Zhang; H. Cheng; Q. Cao; Y. Ke, Oncogene, 2018

The Src homology 2 domain-containing protein tyrosine phosphatase 2 (Shp2) is generally considered to be an oncogene owing to its ability in enhancing the malignancy of multiple types of tumor cells; however, its role in modulating tumor immunity remains largely elusive. Here, we reported that ...

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Multiplex assessment of protein variant abundance by massively parallel sequencing

21-May-2018 | Kenneth A. Matreyek; Lea M. Starita; Jason J. Stephany; Beth Martin; Melissa A. Chiasson; Vanessa E. Gray; Martin Ki ..., Nature Genetics, 2018

Determining the pathogenicity of genetic variants is a critical challenge, and functional assessment is often the only option. Experimentally characterizing millions of possible missense variants in thousands of clinically important genes requires generalizable, scalable assays. We describe ...

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Marine Drugs, Vol. 16, Pages 166: Anticancer Activity of Euplotin C, Isolated from the Marine Ciliate Euplotes crassus, Against Human Melanoma Cells

16-May-2018 | Carpi, Sara ; Polini, Beatrice ; Poli, Giulio ; Alcantara Barata, Gabriela ; Fogli, Stefano ; Romanini, Antonella ; ..., Marine Drugs, 2018

Marine Drugs, Vol. 16, Pages 166: Anticancer Activity of Euplotin C, Isolated from the Marine Ciliate Euplotes crassus, Against Human Melanoma Cells Marine Drugs doi: 10.3390/md16050166 Authors: Sara Carpi Beatrice Polini Giulio Poli Gabriela Alcantara Barata Stefano ...

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Endostatin gene therapy delivered by attenuated Salmonella typhimurium in murine tumor models

14-May-2018 | Kang Liang; Qing Liu; Pei Li; Yue Han; Xiaoping Bian; Yibo Tang; Qingke Kong, Cancer Gene Therapy, 2018

Salmonella typhimurium (hereafter S. typhimurium), as Gram-negative facultative anaerobic bacteria, are good candidates for cancer therapy and delivering therapeutic antitumor agents. However, it is necessary to reduce the virulence of such bacteria and enhance their tumor-targeting ability, and ...

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Tumour mutation status and melanoma recurrence following a negative sentinel lymph node biopsy

14-May-2018 | Nikki R. Adler; Rory Wolfe; Grant A. McArthur; John W. Kelly; Andrew Haydon; Catriona A. McLean; Victoria J. Mar, British Journal of Cancer, 2018

A proportion of patients develop recurrence following a tumour-negative sentinel lymph node biopsy (SLNB). This study aimed to explore whether melanoma patients with BRAF or NRAS mutant tumours have an increased risk of developing disease recurrence following a negative SLNB compared to patients ...

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