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276 Newest Publications about the topic liver cells

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Cancer immunity thwarted by the microbiome

25-May-2018 | Nadine Hartmann; Mitchell Kronenberg, Science , 2018

Liver cancer rates have tripled since 1980, making it one of the leading causes of cancer deaths worldwide ( 1 ). The efficacy of a variety of cancer treatments, as well as carcinogenesis itself, can be influenced by the microbiome ( 2 ). Microbiome-cancer interactions are complex, as the ...

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Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages [Physiology]

15-May-2018 | Evan D. Muse; Shan Yu; Chantle R. Edillor; Jenhan Tao; Nathanael J. Spann; Ty D. Troutman; Jason S. Seidman; Adam He ..., Proceedings of the National Academy of Sciences current issue, 2018

The beneficial effects of LXR-pathway activation have long been appreciated, but clinical application of synthetic LXR ligands has been limited by coactivation of SREBP1c and consequent hypertriglyceridemia. Natural LXR ligands such as desmosterol do not promote hypertriglyceridemia because of ...

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IKKα deficiency disrupts the development of marginal zone and follicular B cells

08-May-2018 | Mumtaz Y. Balkhi; Jami Willette-Brown; Gabor Wittmann; Yinling Hu, Genes and Immunity, 2018

Only few genes have been confidently identified to be involved in the Follicular (FO) and Marginal Zone (MZ) B cell differentiation, migration, and retention in the periphery. Our group previously observed that IKKα kinase inactive mutant mice IKKα K44A/K44A have ...

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Evaluation of the Glypican 3 promoter for transcriptional targeting of hepatocellular carcinoma

21-Mar-2018 | Bijay Dhungel; Slawomir Andrzejewski; Aparna Jayachandran; Ritu Shrestha; Charmaine A. Ramlogan-Steel; Christopher J ..., Gene Therapy, 2018

Hepatocellular carcinoma (HCC) is a major health problem as evidenced by its increasing incidence and high morbidity and mortality rates. Most patients with HCC have underlying liver disease and dysfunction which limits the current therapeutic options. Treatments that spare the liver and destroy ...

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Unexpected Effects of Propiconazole, Tebuconazole, and Their Mixture on the Receptors CAR and PXR in Human Liver Cells

06-Feb-2018 | Knebel C, Neeb J, Zahn E, et al., Toxicological Sciences, 2018

Abstract Analyzing mixture toxicity requires an in-depth understanding of the mechanisms of action of its individual components. Substances with the same target organ, same toxic effect and same mode of action (MoA) are believed to cause additive effects, whereas substances with different MoAs ...

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Marine Drugs, Vol. 16, Pages 25: Lipid-Lowering Polyketides from the Fungus Penicillium Steckii HDN13-279

12-Jan-2018 | Yu, Guihong ; Wang, Shuai ; Wang, Lu ; Che, Qian ; Zhu, Tianjiao ; Zhang, Guojian ; Gu, Qianqun ; Guo, Peng ; Li, Dehai, Marine Drugs, 2018

Marine Drugs, Vol. 16, Pages 25: Lipid-Lowering Polyketides from the Fungus Penicillium Steckii HDN13-279 Marine Drugs doi: 10.3390/md16010025 Authors: Guihong Yu Shuai Wang Lu Wang Qian Che Tianjiao Zhu Guojian Zhang Qianqun Gu Peng Guo Dehai Li Seven new ...

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Comparison among different “revealers” in the study of accelerated blood clearance phenomenon

24-Dec-2017 | Author(s): Kaifan Liang, Lirong Wang, Yuqing Su, Mengyang Liu, Rui Feng, Yanzhi Song, Yihui Deng, European Journal of Pharmaceutical Science, 2017

Publication date: 1 March 2018 Source:European Journal of Pharmaceutical Sciences, Volume 114 Author(s): Kaifan Liang, Lirong Wang, Yuqing Su, Mengyang Liu, Rui Feng, Yanzhi Song, Yihui Deng The markers are the “revealers” of accelerated blood clearance (ABC) phenomenon. ...

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Delivery of the TLR ligand poly(I:C) to liver cells in vitro and in vivo by calcium phosphate nanoparticles leads to a pronounced immunostimulation

19-Nov-2017 | Author(s): Viktoriya Sokolova, Zou Shi, Shunmei Huang, Yanqin Du, Mathis Kopp, Annika Frede, Torben Kn ..., Acta Biomaterialia, 2017

Publication date: December 2017 Source:Acta Biomaterialia, Volume 64 Author(s): Viktoriya Sokolova, Zou Shi, Shunmei Huang, Yanqin Du, Mathis Kopp, Annika Frede, Torben Knuschke, Jan Buer, Dongliang Yang, Jun Wu, Astrid Maria Westendorf, Matthias Epple The selective ...

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In vitro and in vivo study of the application of volvox spheres to co-culture vehicles in liver tissue engineering

24-Sep-2017 | Author(s): Siou Han Chang, Han Hsiang Huang, Pei Leun Kang, Yu Chian Wu, Ming-Huang Chang, Shyh Ming Kuo, Acta Biomaterialia, 2017

Publication date: Available online 21 September 2017 Source:Acta Biomaterialia Author(s): Siou Han Chang, Han Hsiang Huang, Pei Leun Kang, Yu Chian Wu, Ming-Huang Chang, Shyh Ming Kuo Volvox sphere is a biomimetic concept of a natural Volvox, wherein a large outer sphere ...

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Biocompatibility Assessment of Titanium Dioxide Nanoparticles in Mice Feto‐placental Unit

08-Sep-2017 | Parvaneh Naserzadeh, Fatemeh Ghanbary, Parviz Ashtari, Enayatollah Seydi, Khadijeh Ashtari, Mohsen Akbari, Journal of Biomedical Materials Research Part A, 2017

Abstract As the applications of titanium dioxide nanomaterials (nTiO2) are growing with an ever‐increasing speed, the hazardous risks of this material have become a major concern. Several recent studies have reported that nTiO2 can cross the placental barrier in pregnant mice and cause ...

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