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1,963 Newest Publications about the topic kinases


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Inositol polyphosphates regulate and predict yeast pseudohyphal growth phenotypes

25-Jun-2018 | Kaitlyn L. Norman; Christian A. Shively; Amberlene J. De La Rocha; Nebibe Mutlu; Sukanya Basu; Paul J. Cullen; Anuj ..., PLoS Genetics, 2018

by Kaitlyn L. Norman, Christian A. Shively, Amberlene J. De La Rocha, Nebibe Mutlu, Sukanya Basu, Paul J. Cullen, Anuj Kumar Pseudohyphal growth is a nutrient-regulated program in which budding yeast form multicellular filaments of elongated and connected cells. Filamentous growth is required ...


Crosstalk between the serine/threonine kinase StkP and the response regulator ComE controls the stress response and intracellular survival of Streptococcus pneumoniae

08-Jun-2018 | Germán E. Piñas; Nicolás M. Reinoso-Vizcaino; Nubia Y. Yandar Barahona; Paulo R. Cortes; Rosario Duran; Chandan Bada ..., PLoS Pathogens, 2018

by Germán E. Piñas, Nicolás M. Reinoso-Vizcaino, Nubia Y. Yandar Barahona, Paulo R. Cortes, Rosario Duran, Chandan Badapanda, Ankita Rathore, Dario R. Bichara, Melina B. Cian, Nadia B. Olivero, Daniel R. Perez, José Echenique Streptococcus pneumoniae is an opportunistic human bacterial pathogen ...


Histone depletion prevents telomere fusions in pre-senescent cells

07-Jun-2018 | Marta Barrientos-Moreno; Marina Murillo-Pineda; Ana M. Muñoz-Cabello; Félix Prado, PLoS Genetics, 2018

by Marta Barrientos-Moreno, Marina Murillo-Pineda, Ana M. Muñoz-Cabello, Félix Prado Upon telomerase inactivation, telomeres gradually shorten with each cell division until cells enter replicative senescence. In Saccharomyces cerevisiae, the kinases Mec1/ATR and Tel1/ATM protect the genome ...


Two Ck1{delta} transcripts regulated by m6A methylation code for two antagonistic kinases in the control of the circadian clock [Cell Biology]

05-Jun-2018 | Jean-Michel Fustin; Rika Kojima; Kakeru Itoh; Hsin-Yi Chang; Ye Shiqi; Bowen Zhuang; Asami Oji; Shingo Gibo; Rajesh ..., Proceedings of the National Academy of Sciences current issue, 2018

The most abundant modification in mRNA is the N 6-methylation of internal adenosines (m6A), but m6A’s physiological function is unknown for most mRNAs. Here we show that Casein Kinase 1 Delta mRNA ( Ck1δ ), coding for a critical kinase in the control of circadian rhythms, is regulated by m6A. ...


Viruses, Vol. 10, Pages 306: 1-Benzyl-3-cetyl-2-methylimidazolium Iodide (NH125) Is a Broad-Spectrum Inhibitor of Virus Entry with Lysosomotropic Features

05-Jun-2018 | Moeschler, Sarah ; Locher, Samira ; Zimmer, Gert, Viruses, 2018

Viruses, Vol. 10, Pages 306: 1-Benzyl-3-cetyl-2-methylimidazolium Iodide (NH125) Is a Broad-Spectrum Inhibitor of Virus Entry with Lysosomotropic Features Viruses doi: 10.3390/v10060306 Authors: Sarah Moeschler Samira Locher Gert Zimmer Cellular kinases are crucial for the ...


Arrayed CRISPR screen with image-based assay reliably uncovers host genes required for coxsackievirus infection [METHOD]

01-Jun-2018 | Heon Seok Kim; Kyungjin Lee; Seong-Jun Kim; Sungchan Cho; Hye Jin Shin; Chonsaeng Kim; Jin-Soo Kim, Genome Research, 2018

Pooled CRISPR screens based on lentiviral systems have been widely applied to identify the effect of gene knockout on cellular phenotype. Although many screens were successful, they also have the limitation that genes conferring mild phenotypes or those essential for growth can be overlooked, as ...


Separable roles for Mec1/ATR in genome maintenance, DNA replication, and checkpoint signaling [Research Papers]

01-Jun-2018 | Michael Charles Lanz; Susannah Oberly; Ethan James Sanford; Sushma Sharma; Andrei Chabes; Marcus Bustamante Smolka, Genes & Development, 2018

The Mec1/ATR kinase coordinates multiple cellular responses to replication stress. In addition to its canonical role in activating the checkpoint kinase Rad53, Mec1 also plays checkpoint-independent roles in genome maintenance that are not well understood. Here we used a combined ...


In silico-in vitro discovery of untargeted kinase–inhibitor interactions from kinase-targeted therapies: A case study on the cancer MAPK signaling pathway

27-May-2018 | Author(s): Li Meng, Zhijun Huang, Computational Biology and Chemistry, 2018

Publication date: August 2018 Source:Computational Biology and Chemistry, Volume 75 Author(s): Li Meng, Zhijun Huang Protein kinase inhibitors have been widely used as therapeutic agents to treat a variety of diseases, but many of them may cause off-target effects by unexpectedly ...


MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models

24-May-2018 | Zheng Xue; Daniel J. Vis; Alejandra Bruna; Tonci Sustic; Sake van Wageningen; Ankita Sati Batra; Oscar M. Rueda; Eve ..., Cell Research, 2018

Activation of the mitogen-activated protein kinase (MAPK) pathway is frequent in cancer. Drug development efforts have been focused on kinases in this pathway, most notably on RAF and MEK. We show here that MEK inhibition activates JNK-JUN signaling through suppression of DUSP4, leading to ...


Marine Drugs, Vol. 16, Pages 175: Molecular Targets of Active Anticancer Compounds Derived from Marine Sources

22-May-2018 | Song, Xiaoping ; Xiong, Ying ; Qi, Xin ; Tang, Wei ; Dai, Jiajia ; Gu, Qianqun ; Li, Jing, Marine Drugs, 2018

Marine Drugs, Vol. 16, Pages 175: Molecular Targets of Active Anticancer Compounds Derived from Marine Sources Marine Drugs doi: 10.3390/md16050175 Authors: Xiaoping Song Ying Xiong Xin Qi Wei Tang Jiajia Dai Qianqun Gu Jing Li Over the past decades, a number of novel ...


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