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157 Newest Publications about the topic immunotherapies

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Activated integrins identify functional antigen-specific CD8+ T cells within minutes after antigen stimulation [Immunology and Inflammation]

12-Jun-2018 | Stoyan Dimitrov; Cécile Gouttefangeas; Luciana Besedovsky; Anja T. R. Jensen; P. Anoop Chandran; Elisa Rusch; Ramona ..., Proceedings of the National Academy of Sciences current issue, 2018

Assessing antigen-specific T cells is crucial for our understanding of immune reactions against pathogens and tumors, and for evaluating immunotherapies in patients. Existing techniques to evaluate the functionality of T lymphocytes all rely on de novo expression of proteins, typically ...

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Killing without poking holes

25-May-2018 | Stella Hurtley; Anand Balasubramani, Science , 2018

Cancer Immunology Given the success of T cell–centric cancer immunotherapies, there is considerable interest in understanding exactly how tumors sometimes evade this form of treatment. Kearney et al. carried out a series of genome-wide CRISPR screens to identify mechanisms of tumor immune evasion

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Clinical utility of circulating non-coding RNAs — an update

21-May-2018 | Simone Anfossi; Anna Babayan; Klaus Pantel; George A. Calin, Nature Clinical Practice Oncology, 2018

Over the past decade, the amount of research and the number of publications on associations between circulating small and long non-coding RNAs (ncRNAs) and cancer have grown exponentially. Particular focus has been placed on the development of diagnostic and prognostic biomarkers to enable ...

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Integrating oncolytic viruses in combination cancer immunotherapy

09-May-2018 | Praveen K. Bommareddy; Megha Shettigar; Howard L. Kaufman, Nature Reviews Immunology, 2018

Oncolytic viruses can be usefully integrated into tumour immunotherapies, as they target multiple steps within the cancer–immunity cycle. Oncolytic viruses directly lyse tumour cells, leading to the release of soluble antigens, danger signals and type I interferons, which drive antitumour ...

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Integrating oncolytic viruses in combination cancer immunotherapy

09-May-2018 | Praveen K. Bommareddy; Megha Shettigar; Howard L. Kaufman, Nature Reviews Immunology, 2018

Oncolytic viruses can be usefully integrated into tumour immunotherapies, as they target multiple steps within the cancer–immunity cycle. Oncolytic viruses directly lyse tumour cells, leading to the release of soluble antigens, danger signals and type I interferons, which drive antitumour ...

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Therapeutic developments in pancreatic cancer: current and future perspectives

01-May-2018 | John P. Neoptolemos; Jörg Kleeff; Patrick Michl; Eithne Costello; William Greenhalf; Daniel H. Palmer, Nature Clinical Practice Gastroenterology & Hepatology, 2018

The overall 5-year survival for pancreatic cancer has changed little over the past few decades, and pancreatic cancer is predicted to be the second leading cause of cancer-related mortality in the next decade in Western countries. The past few years, however, have seen improvements in first-line ...

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Current state of immunotherapy for glioblastoma

11-Apr-2018 | Michael Lim; Yuanxuan Xia; Chetan Bettegowda; Michael Weller, Nature Clinical Practice Oncology, 2018

Glioma is the most common primary cancer of the central nervous system, and around 50% of patients present with the most aggressive form of the disease, glioblastoma. Conventional therapies, including surgery, radiotherapy, and pharmacotherapy (typically chemotherapy with temozolomide), have not ...

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Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges

06-Mar-2018 | Dai Fukumura; Jonas Kloepper; Zohreh Amoozgar; Dan G. Duda; Rakesh K. Jain, Nature Clinical Practice Oncology, 2018

Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges, Published online: 06 March 2018; doi:10.1038/nrclinonc.2018.29 The aberrant tumour vasculature and the associated angiogenic ...

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An immunosuppressive pathway for tumor progression

06-Mar-2018 | Antoine Marçais; Thierry Walzer, Nature Medicine, 2018

An immunosuppressive pathway for tumor progression An immunosuppressive pathway for tumor progression, Published online: 06 March 2018; doi:10.1038/nm.4508 An active immunosuppressive pathway is identified in colon cancer that confers immune evasion by the cancer and can be targeted to synergize ...

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Potentiating prostate cancer immunotherapy with oncolytic viruses

13-Feb-2018 | Patrick Lee; Shashi Gujar, Nature Clinical Practice Urology, 2018

Potentiating prostate cancer immunotherapy with oncolytic viruses Potentiating prostate cancer immunotherapy with oncolytic viruses, Published online: 13 February 2018; doi:10.1038/nrurol.2018.10 Lee and Gujar review the potential of virotherapy to increase the effectiveness of immunotherapies ...

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