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3,042 Newest Publications about the topic immunology

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Distinct human circulating NKp30+FcϵRI{gamma}+CD8+ T cell population exhibiting high natural killer-like antitumor potential [Immunology and Inflammation]

26-Jun-2018 | Margareta P. Correia; Ana Stojanovic; Katharina Bauer; Dilafruz Juraeva; Lars-Oliver Tykocinski; Hanns-Martin Lorenz ..., Proceedings of the National Academy of Sciences current issue, 2018

CD8+ T cell recognition of tumor cells is typically based on the detection of specific MHC–peptide complexes, while natural killer (NK) cell recognition relies on the detection of NK ligands by an array of NK receptors. In this study we uncovered a distinct small population of CD8+ T cells ...

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Pharmaceuticals, Vol. 11, Pages 64: Insights into Macrophage Heterogeneity and Cytokine-Induced Neuroinflammation in Major Depressive Disorder

25-Jun-2018 | Dey, Adwitia ; Hankey Giblin, Pamela A., Pharmaceuticals, 2018

Pharmaceuticals, Vol. 11, Pages 64: Insights into Macrophage Heterogeneity and Cytokine-Induced Neuroinflammation in Major Depressive Disorder Pharmaceuticals doi: 10.3390/ph11030064 Authors: Adwitia Dey Pamela A. Hankey Giblin Over 350 million individuals suffer from depression, ...

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Surface antibody maturation

22-Jun-2018 | Caroline Ash; Seth Thomas Scanlon, Science , 2018

Immunology Affinity maturation in B cells generates antibodies with increasingly enhanced antigen-binding properties. Imkeller et al. investigated the maturation of human B cells that express protective antibodies against the circumsporozoite protein of the malaria-causing parasite Plasmodium

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Cell-intrinsic regulation of murine epidermal Langerhans cells by protein S [Immunology and Inflammation]

19-Jun-2018 | Yaara Tabib; Nora S. Jaber; Maria Nassar; Tal Capucha; Gabriel Mizraji; Tsipora Nir; Noam Koren; Itay Aizenbud; Avra ..., Proceedings of the National Academy of Sciences current issue, 2018

Langerhans cells (LCs) are the exclusive antigen-presenting cells of the epidermis, capable of mounting immunity and tolerance. LCs maintain themselves locally by self-renewing throughout life, a process that is regulated by both LCs and keratinocytes. Nevertheless, the mechanisms underlying this ...

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BP180 dysfunction triggers spontaneous skin inflammation in mice [Immunology and Inflammation]

19-Jun-2018 | Yang Zhang; Bin-Jin Hwang; Zhen Liu; Ning Li; Kendall Lough; Scott E. Williams; Jinbo Chen; Susan W. Burette; Luis A ..., Proceedings of the National Academy of Sciences current issue, 2018

BP180 is a cell–cell matrix adhesion molecule and is critical for attachment of epidermis to underlying dermis. We generated a dysfunctional BP180 mouse strain (Δ NC16A mice). The Δ NC16A mice at 8 weeks start developing spontaneous itch and skin inflammation characterized by increased skin ...

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Letting thymocytes go

15-Jun-2018 | Stella Hurtley; John F. Foley, Science , 2018

Immunology During the process of T cell development, thymocytes must travel from the cortex of the thymus to the medulla, where potentially autoreactive cells are removed by negative selection. Duke-Cohan et al. found that mouse thymocytes lacking the guanosine triphosphatase–activating protein

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HCMV glycoprotein B subunit vaccine efficacy mediated by nonneutralizing antibody effector functions [Immunology and Inflammation]

12-Jun-2018 | Cody S. Nelson; Tori Huffman; Jennifer A. Jenks; Eduardo Cisneros de la Rosa; Guanhua Xie; Nathan Vandergrift; Rober ..., Proceedings of the National Academy of Sciences current issue, 2018

The CDC estimates that every hour, a child is born in the United States with permanent neurologic disability resulting from human cytomegalovirus (HCMV) infection—more than is caused by Down syndrome, fetal alcohol syndrome, and neural tube defects combined. A maternal vaccine to block ...

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Recombinant cytomegalovirus glycoprotein B vaccine: Rethinking the immunological basis of protection [Immunology and Inflammation]

12-Jun-2018 | Mark R. Schleiss, Proceedings of the National Academy of Sciences current issue, 2018

Development and licensure of a vaccine against human CMV infection is a major public health priority. Although the major driving force for a CMV vaccine is prevention of congenital infection—since CMV is the most common viral cause of permanent neurodevelopmental disability in infants globally ...

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[Immunology] Which Dengue Vaccine Approach Is the Most Promising, and Should We Be Concerned about Enhanced Disease after Vaccination?: Questions Raised by the Development and Implementation of Dengue Vaccines: Example of the Sanofi Pasteur Tetravalent Dengue Vaccine

01-Jun-2018 | Bruno Guy, CSH Perspectives, 2018

Dengue is a still-growing public health concern in many tropical and subtropical regions of the world. The development and implementation of an effective dengue vaccine in these regions is a high priority. This insight focuses on the expected characteristics of a safe and efficacious vaccine, ...

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[Immunology] Which Dengue Vaccine Approach Is the Most Promising, and Should We Be Concerned about Enhanced Disease after Vaccination?: The Path to a Dengue Vaccine: Learning from Human Natural Dengue Infection Studies and Vaccine Trials

01-Jun-2018 | Aravinda M. de Silva; Eva Harris, CSH Perspectives, 2018

Dengue virus (DENV) is the most common arthropod-borne viral disease of humans. Although effective vaccines exist against other flaviviral diseases like yellow fever and Japanese encephalitis, dengue vaccine development is complicated by the presence of four virus serotypes and the possibility of ...

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