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3,042 Newest Publications about the topic immunologyrss
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26-Jun-2018 | Margareta P. Correia; Ana Stojanovic; Katharina Bauer; Dilafruz Juraeva; Lars-Oliver Tykocinski; Hanns-Martin Lorenz ..., Proceedings of the National Academy of Sciences current issue, 2018
CD8+ T cell recognition of tumor cells is typically based on the detection of specific MHC–peptide complexes, while natural killer (NK) cell recognition relies on the detection of NK ligands by an array of NK receptors. In this study we uncovered a distinct small population of CD8+ T cells ...
25-Jun-2018 | Dey, Adwitia ; Hankey Giblin, Pamela A., Pharmaceuticals, 2018
Pharmaceuticals, Vol. 11, Pages 64: Insights into Macrophage Heterogeneity and Cytokine-Induced Neuroinflammation in Major Depressive Disorder Pharmaceuticals doi: 10.3390/ph11030064 Authors: Adwitia Dey Pamela A. Hankey Giblin Over 350 million individuals suffer from depression, ...
22-Jun-2018 | Caroline Ash; Seth Thomas Scanlon, Science , 2018
Immunology Affinity maturation in B cells generates antibodies with increasingly enhanced antigen-binding properties. Imkeller et al. investigated the maturation of human B cells that express protective antibodies against the circumsporozoite protein of the malaria-causing parasite Plasmodium
19-Jun-2018 | Yaara Tabib; Nora S. Jaber; Maria Nassar; Tal Capucha; Gabriel Mizraji; Tsipora Nir; Noam Koren; Itay Aizenbud; Avra ..., Proceedings of the National Academy of Sciences current issue, 2018
Langerhans cells (LCs) are the exclusive antigen-presenting cells of the epidermis, capable of mounting immunity and tolerance. LCs maintain themselves locally by self-renewing throughout life, a process that is regulated by both LCs and keratinocytes. Nevertheless, the mechanisms underlying this ...
19-Jun-2018 | Yang Zhang; Bin-Jin Hwang; Zhen Liu; Ning Li; Kendall Lough; Scott E. Williams; Jinbo Chen; Susan W. Burette; Luis A ..., Proceedings of the National Academy of Sciences current issue, 2018
BP180 is a cell–cell matrix adhesion molecule and is critical for attachment of epidermis to underlying dermis. We generated a dysfunctional BP180 mouse strain (Δ NC16A mice). The Δ NC16A mice at 8 weeks start developing spontaneous itch and skin inflammation characterized by increased skin ...
15-Jun-2018 | Stella Hurtley; John F. Foley, Science , 2018
Immunology During the process of T cell development, thymocytes must travel from the cortex of the thymus to the medulla, where potentially autoreactive cells are removed by negative selection. Duke-Cohan et al. found that mouse thymocytes lacking the guanosine triphosphatase–activating protein
12-Jun-2018 | Cody S. Nelson; Tori Huffman; Jennifer A. Jenks; Eduardo Cisneros de la Rosa; Guanhua Xie; Nathan Vandergrift; Rober ..., Proceedings of the National Academy of Sciences current issue, 2018
The CDC estimates that every hour, a child is born in the United States with permanent neurologic disability resulting from human cytomegalovirus (HCMV) infection—more than is caused by Down syndrome, fetal alcohol syndrome, and neural tube defects combined. A maternal vaccine to block ...
12-Jun-2018 | Mark R. Schleiss, Proceedings of the National Academy of Sciences current issue, 2018
Development and licensure of a vaccine against human CMV infection is a major public health priority. Although the major driving force for a CMV vaccine is prevention of congenital infection—since CMV is the most common viral cause of permanent neurodevelopmental disability in infants globally ...
01-Jun-2018 | Bruno Guy, CSH Perspectives, 2018
Dengue is a still-growing public health concern in many tropical and subtropical regions of the world. The development and implementation of an effective dengue vaccine in these regions is a high priority. This insight focuses on the expected characteristics of a safe and efficacious vaccine, ...
01-Jun-2018 | Aravinda M. de Silva; Eva Harris, CSH Perspectives, 2018
Dengue virus (DENV) is the most common arthropod-borne viral disease of humans. Although effective vaccines exist against other flaviviral diseases like yellow fever and Japanese encephalitis, dengue vaccine development is complicated by the presence of four virus serotypes and the possibility of ...