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17 Newest Publications about the topic hplc systems


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A New Validated HPLC Method for the Determination of Quercetin: Application to Study Pharmacokinetics in Rats

24-Aug-2016 | Khaled S. Abdelkawy, Mark E. Balyshev, Fawzy Elbarbry, Biomedical Chromatography, 2016

Abstract A simple, accurate, and reproducible High Performance Liquid Chromatography (HPLC) method has been developed and validated for the quantification of quercetin (QR) in rat plasma. The method involves a simple protein precipitation procedure to extract both QR and thymoquinone (TQ), the ...


Pharmaceuticals, Vol. 9, Pages 51: Design and Prototype of an Automated Column-Switching HPLC System for Radiometabolite Analysis

17-Aug-2016 | Vasdev, Neil ; Collier, Thomas Lee, Pharmaceuticals, 2016

Column-switching high performance liquid chromatography (HPLC) is extensively used for the critical analysis of radiolabeled ligands and their metabolites in plasma. However, the lack of streamlined apparatus and consequently varying protocols remain as a challenge among positron emission ...


Antiproliferative and antioxidant activities of Turkish pomegranate (Punica granatum L.) accessions

05-Aug-2013 | Mehmet Karaaslan, Hasan Vardin, Suzan Varlıklıöz, Fatih M. Yılmaz, International Journal of Food Science & Technology, 2013

Summary The objective of this study was to assess antioxidant and antiproliferative activities of four different Turkish pomegranate varieties (Hatay, Hicaz, Adana and Antalya) using an in vitro HepG2 cancer cell model. All the pomegranate extracts employed in this study significantly diminish ...


Evaluation of the suitability of chromatographic systems to predict human skin permeation of neutral compounds

22-Apr-2013 | Author(s): Marta Hidalgo-Rodríguez , Sara Soriano-Meseguer , Elisabet Fuguet , Clara Ràfols , Martí Rosés, European Journal of Pharmaceutical Science, 2013

Publication date: Available online 19 April 2013Source:European Journal of Pharmaceutical Sciences Author(s): Marta Hidalgo-Rodríguez , Sara Soriano-Meseguer , Elisabet Fuguet , Clara Ràfols , Martí Rosés Several chromatographic systems (three systems of high-performance liquid ...


Evaluation of vanillic acid as inhibitor of carbonic anhydrase isozyme III by using a modified Hummel–Dreyer method: approach for drug discovery

19-Apr-2013 | Muhammed Alzweiri, Yusuf Al‐Hiari, Biomedical Chromatography, 2013

ABSTRACT α‐3 carbonic anhydrase isozyme (CAIII) is the most abundant protein in adipocytes and considered insensitive to sulfonamide inhibitors. It was reported recently that the knock‐down of CAIII is attributed with controlling lipogenesis. Thus inhibition of this target may lead to the ...


Quantitative determination of famotidine in human maternal plasma, umbilical cord plasma and urine using high‐performance liquid chromatography–mass spectrometry

12-Feb-2013 | Xiaoming Wang, Erik Rytting, Doaa R. Abdelrahman, Tatiana N. Nanovskaya, Gary D.V. Hankins, Mahmoud S. Ahmed, Biomedical Chromatography, 2013

ABSTRACT Liquid chromatography with electrospray ionization mass spectrometry for the quantitative determination of famotidine in human urine, maternal and umbilical cord plasma was developed and validated. The plasma samples were alkalized with ammonium hydroxide and extracted twice with ...


Simple column‐switching HPLC method for determining levels of the antifungal agent micafungin in human plasma and application to patient samples

11-Oct-2012 | Saori Nakagawa, Naoko Kuwabara, Hikaru Kobayashi, Sadahiko Shimoeda, Shin Ohta, Susumu Yamato, Biomedical Chromatography, 2012

ABSTRACT Micafungin is an echinocandin antifungal agent that is important for treating candidiasis in emergency and intensive care medicine; however, current methods for measuring micafungin plasma levels are lengthy and complicated. We report a simple quantitative method using ...


Effect of maturation conditions on sensory and antioxidant properties of old Serbian plum brandies

13-Jul-2012 | Sonja Pecić, M. Veljović, S. Despotović, I. Leskošek-Čukalović, M. Jadranin, V. Tešević, M. Nikšić, N. Nikićević, European Food Research and Technology, 2012

Šljivovica and Prepečenica are traditional Serbian distillated beverages made from varieties of plum, of the genus Prunus. The ageing in wooden casks not only improves the sensory characteristics, but also changes the content of total polyphenols and contributes to the other important health ...


Isolation and identification of steroidogenic peptides from calf spleen

03-May-2012 | Jun-Pil Jee, Su-Eon Jin, Eunmi Ban, Hyo-Jong Lee, Youmie Park, Yohan Park, Han-Joo Maeng, Hyung Tae Kim, Chong-Kook Kim, Archives of Pharmacal Research, 2012

Since women with climacteric syndrome have significantly lower serum levels of estradiol and other related hormones, hormone replacement therapies (HRT) such as estrogen are needed to lessen symptoms. However, HRT can often cause severe adverse effects that include many cancers and stroke. ...


LC‐MS/MS method for simultaneous analysis of uracil, 5,6‐dihydrouracil, 5‐fluorouracil and 5‐fluoro‐5,6‐dihydrouracil in human plasma for therapeutic drug monitoring and toxicity prediction in cancer patients

27-Mar-2012 | Büchel, Barbara; Rhyn, Peter; Schürch, Stefan; Bühr, Claudia; Amstutz, Ursula; R. Largiadèr, Carlo, Biomedical Chromatography, 2012

ABSTRACT The chemotherapeutic drug 5‐fluorouracil (5‐FU) is widely used for treating solid tumors. Response to 5‐FU treatment is variable with 10–30% of patients experiencing serious toxicity partly explained by reduced activity of dihydropyrimidine dehydrogenase (DPD). DPD converts endogenous ...


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