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1,991 Newest Publications about the topic genomics

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Receptor networks underpin plant immunity

22-Jun-2018 | Chih-Hang Wu; Lida Derevnina; Sophien Kamoun, Science , 2018

Plants are attacked by a multitude of pathogens and pests, some of which cause epidemics that threaten food security. Yet a fundamental concept in plant pathology is that most plants are actively resistant to most pathogens and pests. Plants fend off their innumerable biotic foes primarily ...

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Transdifferentiation of human adult peripheral blood T cells into neurons [Neuroscience]

19-Jun-2018 | Koji Tanabe; Cheen Euong Ang; Soham Chanda; Victor Hipolito Olmos; Daniel Haag; Douglas F. Levinson; Thomas C. Südho ..., Proceedings of the National Academy of Sciences current issue, 2018

Recent advances in genomics have revealed that many polygenetic diseases are caused by complex combinations of many common variants with individually small effects. Thus, building informative disease models requires the interrogation of many patient-derived genetic backgrounds in a ...

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Reconciling species diversity in a tropical plant clade (Canarium, Burseraceae)

15-Jun-2018 | Sarah Federman; Michael J. Donoghue; Douglas C. Daly; Deren A. R. Eaton, PLoS ONE, 2018

by Sarah Federman, Michael J. Donoghue, Douglas C. Daly, Deren A. R. Eaton The challenges associated with sampling rare species or populations can limit our ability to make accurate and informed estimates of biodiversity for clades or ecosystems. This may be particularly true for tropical ...

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Extant fold-switching proteins are widespread [Biophysics and Computational Biology]

05-Jun-2018 | Lauren L. Porter; Loren L. Looger, Proceedings of the National Academy of Sciences current issue, 2018

It is commonly thought that each globular protein has a single 3D structure, or fold, that fosters its function. In contrast, recent studies have identified several fold-switching proteins whose secondary structures can be remodeled in response to cellular stimuli. Although thought to be rare, we ...

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Comprehensive viral enrichment enables sensitive respiratory virus genomic identification and analysis by next generation sequencing [METHOD]

01-Jun-2018 | O'Flaherty, B. M., Li, Y., Tao, Y., Paden, C. R., Queen, K., Zhang, J., Dinwiddie, D. L., Gross, S. M., Schroth, G. ..., Genome Research, 2018

Next generation sequencing (NGS) technologies have revolutionized the genomics field and are becoming more commonplace for identification of human infectious diseases. However, due to the low abundance of viral nucleic acids (NAs) in relation to host, viral identification using direct NGS ...

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Selection and environmental adaptation along a path to speciation in the Tibetan frog Nanorana parkeri [Evolution]

29-May-2018 | Guo-Dong Wang; Bao-Lin Zhang; Wei-Wei Zhou; Yong-Xin Li; Jie-Qiong Jin; Yong Shao; He-chuan Yang; Yan-Hu Liu; Fang Y ..., Proceedings of the National Academy of Sciences current issue, 2018

Central topics in evolutionary biology include uncovering the processes and genetic bases of speciation and documenting environmental adaptations and processes responsible for them. The challenging environment of the Qinghai-Tibetan Plateau (QTP) facilitates such investigations, and the Tibetan ...

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Hardware acceleration of BWA-MEM genomic short read mapping for longer read lengths

27-May-2018 | Author(s): Ernst Joachim Houtgast, Vlad-Mihai Sima, Koen Bertels, Zaid Al-Ars, Computational Biology and Chemistry, 2018

Publication date: Available online 12 April 2018 Source:Computational Biology and Chemistry Author(s): Ernst Joachim Houtgast, Vlad-Mihai Sima, Koen Bertels, Zaid Al-Ars We present our work on hardware accelerated genomics pipelines, using either FPGAs or GPUs to accelerate ...

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The case of GWAS of obesity: does body weight control play by the rules?

24-May-2018 | Manfred J. Müller; Corinna Geisler; John Blundell; Abdul Dulloo; Yves Schutz; Michael Krawczak; Anja Bosy-Westp ..., International Journal of Obesity, 2018

As yet, genome-wide association studies (GWAS) have not added much to our understanding of the mechanisms of body weight control and of the etiology of obesity. This shortcoming is widely attributed to the complexity of the issues. The appeal of this explanation notwithstanding, we surmise that ...

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Comparative mRNA and miRNA expression in European mouflon (Ovis musimon) and sheep (Ovis aries) provides novel insights into the genetic mechanisms for female reproductive success

21-May-2018 | Ji Yang; Xin Li; Yin-Hong Cao; Kisun Pokharel; Xiao-Ju Hu; Ze-Hui Chen; Song-Song Xu; Jaana Peippo; Mervi Honkatukia ..., Heredity, 2018

Prolific breeds of domestic sheep (Ovis aries) are important genetic resources due to their reproductive performance, which is characterized by multiple lambs per birth and out-of-season breeding. However, the lack of a comprehensive understanding of the genetic mechanisms underlying the ...

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Methylation guide RNA evolution in archaea: structure, function and genomic organization of 110 C/D box sRNA families across six Pyrobaculum species

16-May-2018 | Lui L, Uzilov A, Bernick D, et al., Nucleic Acids Research, 2018

Abstract Archaeal homologs of eukaryotic C/D box small nucleolar RNAs (C/D box sRNAs) guide precise 2′-O-methyl modification of ribosomal and transfer RNAs. Although C/D box sRNA genes constitute one of the largest RNA gene families in archaeal thermophiles, most genomes have incomplete sRNA gene ...

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