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1,068 Newest Publications about the topic genome sequencing

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Evolution via recombination: Cell-to-cell contact facilitates larger recombination events in Streptococcus pneumoniae

13-Jun-2018 | Lauren A. Cowley; Fernanda C. Petersen; Roger Junges; Med Jimson D. Jimenez; Donald A. Morrison; William P. Hanage, PLoS Genetics, 2018

by Lauren A. Cowley, Fernanda C. Petersen, Roger Junges, Med Jimson D. Jimenez, Donald A. Morrison, William P. Hanage Homologous recombination in the genetic transformation model organism Streptococcus pneumoniae is thought to be important in the adaptation and evolution of this pathogen. While ...

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Viruses, Vol. 10, Pages 319: The First Isolation and Whole Genome Sequencing of Murray Valley Encephalitis Virus from Cerebrospinal Fluid of a Patient with Encephalitis

11-Jun-2018 | Russell, Jessica S.; Caly, Leon ; Kostecki, Renata ; McGuinness, Sarah L.; Carter, Glen ; Bulach, Dieter ; Seemann ..., Viruses, 2018

Viruses, Vol. 10, Pages 319: The First Isolation and Whole Genome Sequencing of Murray Valley Encephalitis Virus from Cerebrospinal Fluid of a Patient with Encephalitis Viruses doi: 10.3390/v10060319 Authors: Jessica S. Russell Leon Caly Renata Kostecki Sarah L. McGuinness Glen ...

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Resistome of carbapenem- and colistin-resistant Klebsiella pneumoniae clinical isolates

08-Jun-2018 | Sara Lomonaco; Matthew A. Crawford; Christine Lascols; Ruth E. Timme; Kevin Anderson; David R. Hodge; Debra J. Fishe ..., PLoS ONE, 2018

by Sara Lomonaco, Matthew A. Crawford, Christine Lascols, Ruth E. Timme, Kevin Anderson, David R. Hodge, Debra J. Fisher, Segaran P. Pillai, Stephen A. Morse, Erum Khan, Molly A. Hughes, Marc W. Allard, Shashi K. Sharma The emergence and dissemination of carbapenemases, bacterial enzymes able ...

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Comprehensive viral enrichment enables sensitive respiratory virus genomic identification and analysis by next generation sequencing [METHOD]

01-Jun-2018 | O'Flaherty, B. M., Li, Y., Tao, Y., Paden, C. R., Queen, K., Zhang, J., Dinwiddie, D. L., Gross, S. M., Schroth, G. ..., Genome Research, 2018

Next generation sequencing (NGS) technologies have revolutionized the genomics field and are becoming more commonplace for identification of human infectious diseases. However, due to the low abundance of viral nucleic acids (NAs) in relation to host, viral identification using direct NGS ...

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Identity-by-descent analyses for measuring population dynamics and selection in recombining pathogens

23-May-2018 | Lyndal Henden; Stuart Lee; Ivo Mueller; Alyssa Barry; Melanie Bahlo, PLoS Genetics, 2018

by Lyndal Henden, Stuart Lee, Ivo Mueller, Alyssa Barry, Melanie Bahlo Identification of genomic regions that are identical by descent (IBD) has proven useful for human genetic studies where analyses have led to the discovery of familial relatedness and fine-mapping of disease critical regions. ...

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Suppressor mutation analysis combined with 3D modeling explains cohesin’s capacity to hold and release DNA [Genetics]

22-May-2018 | Xingya Xu; Ryuta Kanai; Norihiko Nakazawa; Li Wang; Chikashi Toyoshima; Mitsuhiro Yanagida, Proceedings of the National Academy of Sciences current issue, 2018

The heterodimeric cohesin SMC complex embraces duplex DNA and is associated with Rad21, which is cleaved in mitotic anaphase by a protease called separase/Cut1. Upon Rad21 cleavage, chromosomal DNAs are released from cohesin and segregated. We identified extragenic suppressors for separase and ...

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CRISPR off-target analysis in genetically engineered rats and mice

21-May-2018 | Keith R. Anderson; Maximilian Haeussler; Colin Watanabe; Vasantharajan Janakiraman; Jessica Lund; Zora Modrusan; Jer ..., Nature Methods, 2018

Despite widespread use of CRISPR, comprehensive data on the frequency and impact of Cas9-mediated off-targets in modified rodents are limited. Here we present deep-sequencing data from 81 genome-editing projects on mouse and rat genomes at 1,423 predicted off-target sites, 32 of which were ...

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Genomic insights into the emergence and spread of antimicrobial-resistant bacterial pathogens

18-May-2018 | Stephen Baker; Nicholas Thomson; François-Xavier Weill; Kathryn E. Holt, Science , 2018

Whole-genome sequencing (WGS) has been vital for revealing the rapid temporal and spatial evolution of antimicrobial resistance (AMR) in bacterial pathogens. Some antimicrobial-resistant pathogens have outpaced us, with untreatable infections appearing in hospitals and the community. However, WGS ...

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Distinctive types of postzygotic single-nucleotide mosaicisms in healthy individuals revealed by genome-wide profiling of multiple organs

15-May-2018 | August Yue Huang; Xiaoxu Yang; Sheng Wang; Xianing Zheng; Qixi Wu; Adam Yongxin Ye; Liping Wei, PLoS Genetics, 2018

by August Yue Huang, Xiaoxu Yang, Sheng Wang, Xianing Zheng, Qixi Wu, Adam Yongxin Ye, Liping Wei Postzygotic single-nucleotide mosaicisms (pSNMs) have been extensively studied in tumors and are known to play critical roles in tumorigenesis. However, the patterns and origin of pSNMs in normal ...

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Pharmaceuticals, Vol. 11, Pages 45: Novel N4-Like Bacteriophages of Pectobacterium atrosepticum

14-May-2018 | Buttimer, Colin ; Hendrix, Hanne ; Lucid, Alan ; Neve, Horst ; Noben, Jean-Paul ; Franz, Charles ; O’Mahony, Jim ; L ..., Pharmaceuticals, 2018

Pharmaceuticals, Vol. 11, Pages 45: Novel N4-Like Bacteriophages of Pectobacterium atrosepticum Pharmaceuticals doi: 10.3390/ph11020045 Authors: Colin Buttimer Hanne Hendrix Alan Lucid Horst Neve Jean-Paul Noben Charles Franz Jim O’Mahony Rob Lavigne Aidan ...

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