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34,029 Newest Publications about the topic genes


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Putative storage root specific promoters from cassava and yam: cloning and evaluation in transgenic carrots as a model system

06-Apr-2010 | Jacobo Arango, Bertha Salazar, Ralf Welsch, Felipe Sarmiento, Peter Beyer, Salim Al-Babili, Plant Cell Reports, 2010

A prerequisite for biotechnological improvements of storage roots is the availability of tissue-specific promoters enabling high expression of transgenes. In this work, we cloned two genomic fragments, pMe1 and pDJ3S, controlling the expression of a gene with unknown function from cassava ...


Enhanced adenoviral gene delivery to motor and dorsal root ganglion neurons following injection into demyelinated peripheral nerves

05-Apr-2010 | Yongjie Zhang, Yiyan Zheng, Yi Ping Zhang, Lisa B.E. Shields, Xiaoling Hu, Panpan Yu, Darlene A. Burke, Heming Wang, ..., Journal of Neuroscience Research, 2010

Injection of viral vectors into peripheral nerves may transfer specific genes into their dorsal root ganglion (DRG) neurons and motoneurons. However, myelin sheaths of peripheral axons block the entry of viral particles into nerves. We studied whether mild, transient peripheral nerve ...


Dominant Processes during Human Dendritic Cell Maturation Revealed by Integration of Proteome and Transcriptome at the Pathway Level

05-Apr-2010 | Sonja I. Buschow; Edwin Lasonder; Hanneke W. M. van Deutekom; Machteld M. Oud; Luca Beltrame; Martijn A. Huynen; I. ..., Journal of Proteome Research, 2010

Gene expression is commonly used to study the activation of dendritic cells (DCs) to identify proteins that determine whether these cells induce an immunostimulatory or tolerogenic immune response. RNA expression, however, does not necessarily predict protein abundance and often requires large ...


Subcellular Quantitative Proteomics Reveals Multiple Pathway Cross-Talk That Coordinates Specific Signaling and Transcriptional Regulation for the Early Host Response to LPS

05-Apr-2010 | Ruyun Du; Jing Long; Jun Yao; Yun Dong; Xiaoli Yang; Siwei Tang; Shuai Zuo; Yufei He; Xian Chen, Journal of Proteome Research, 2010

Toll-like receptor 4 (TLR4) specifically recognizes lipopolysaccharide (LPS) to initiate signal transduction events that modulate host inflammatory responses. Although increasing numbers of genes have been characterized individually for their involvement in TLR4 signaling, the LPS-induced ...


Inhibition of Breast Cancer Cell Growth and Invasiveness by Dual Silencing of HER-2 and VEGF

05-Apr-2010 | Wanyi Tai; Bin Qin; Kun Cheng, Molecular Pharmaceutics, 2010

Overexpression of HER-2 accounts for ∼25% of all breast cancer cases, while 87.7% of HER-2 positive breast cancers are associated with upregulated VEGF. The objective of this study is to explore the combination therapy of blocking HER-2 and VEGF expressions simultaneously using siRNA. This is the ...


Analysis of transcriptional synergy between upstream regions and introns in ribosomal protein genes of yeast

04-Apr-2010 | Jun, Hu , Huimin, Li , Jing, Zhang, Computational Biology and Chemistry, 2010

Transcriptional regulation in eukaryotic genes generally requires combinatorial binding on DNA of multiple transcription factors. Though many analyses have been performed for identification of combinatorial patterns in promoter sequences, there are few studies concerned with introns of genes. ...


The CHK2|[ndash]|BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells

04-Apr-2010 | Ailine Stolz, Norman Ertych, Anne Kienitz, Celia Vogel, Verena Schneider, Barbara Fritz, Ralf Jacob, Gunnar Dittmar, ..., Nature Cell Biology, 2010

The CHK2–BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells Nature Cell Biology 12, 492 (2010). doi:10.1038/ncb2051 Authors: Ailine Stolz, Norman Ertych, Anne Kienitz, Celia Vogel, Verena Schneider, Barbara Fritz, Ralf Jacob, Gunnar Dittmar, Wilko ...


Genome-wide association study of intracranial aneurysm identifies three new risk loci

04-Apr-2010 | Katsuhito Yasuno; Kaya Bilguvar; Philippe Bijlenga; Siew-Kee Low; Boris Krischek; Georg Auburger; Matthias Simon; Di ..., Nature Genetics, 2010

Genome-wide association study of intracranial aneurysm identifies three new risk loci Nature Genetics 42, 420 (2010). doi:10.1038/ng.563 Authors: Katsuhito Yasuno, Kaya Bilguvar, Philippe Bijlenga, Siew-Kee Low, Boris Krischek, Georg Auburger, Matthias Simon, Dietmar Krex, Zulfikar Arlier, ...


Expression profiles of glutathione S-transferase genes in larval midgut of Bombyx mori exposed to insect hormones

03-Apr-2010 | Feng-Ming Zou, De-Shuai Lou, Ya-Hong Zhu, Sheng-Peng Wang, Byung-Rae Jin, Zhong-Zheng Gui, Molecular Biology Reports, 2010

Glutathione S-transferases (GSTs) are believed to play a role in the detoxification of xenobiotics, resistance to insect viruses and pesticides, intracellular transport, biosynthesis of hormones and protection against oxidative stress. In this study, we used quantitative real time RT-PCR to ...


The association of polymorphisms in DNA base excision repair genes XRCC1, OGG1 and MUTYH with the risk of childhood acute lymphoblastic leukemia

03-Apr-2010 | M. Stanczyk, T. Sliwinski, M. Cuchra, M. Zubowska, A. Bielecka-Kowalska, M. Kowalski, J. Szemraj, W. Mlynarski, I. M ..., Molecular Biology Reports, 2010

The aim of this study was to evaluate the association of polymorphisms in genes encoding three key proteins of DNA base excision repair (BER): the OGG1 Ser326Cys, the MUTYH Tyr165Cys and the XRCC1 Arg399Gln with the risk of childhood acute lymphoblastic leukemia (ALL). Our study included 97 ...


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