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70 Newest Publications about the topic gene knockdown


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Monocyte chemotactic protein-induced protein-1 enhances DR5 degradation and negatively regulates DR5 activation-induced apoptosis through its deubiquitinase function

19-Mar-2018 | You-Take Oh; Guoqing Qian; Jiusheng Deng; Shi-Yong Sun, Oncogene, 2018

Monocyte chemotactic protein-induced protein-1 (MCPIP1; also called Regnase-1) encoded by the ZC3H12A gene critically regulates inflammatory responses and immune homeostasis primarily by RNase-dependent and -independent mechanisms. However, the relationship of MCPIP1 with apoptosis and cancer and ...


Multifunctional peptide-lipid nanocomplexes for efficient targeted delivery of DNA and siRNA into breast cancer cells

06-Aug-2017 | Author(s): Yu Wan, Wei Dai, Reshma J. Nevagi, Istvan Toth, Peter M. Moyle, Acta Biomaterialia, 2017

Publication date: 1 September 2017 Source:Acta Biomaterialia, Volume 59 Author(s): Yu Wan, Wei Dai, Reshma J. Nevagi, Istvan Toth, Peter M. Moyle The development of carriers for the delivery of oligonucleotide therapeutics is essential for the successful translation of gene ...


Efficient Receptor Mediated siRNA Delivery in Vitro by Folic Acid Targeted Pentablock Copolymer-Based Micelleplexes

25-Jul-2017 | Roman Lehner; Kegang Liu; Xueya Wang; Patrick Hunziker, Biomacromolecules, 2017

Novel, biocompatible polyplexes, based on the combination of cationic pentablock copolymers with folic acid functionalized copolymers, were designed and developed for target-specific siRNA delivery. The resulting micelleplexes spontaneously formed polymeric micelles with a hydrophobic core ...


miR‐181d regulates human dendritic cell maturation through NF‐κB pathway

21-Jul-2017 | Xian Wei Su, Gang Lu, Chi Kwan Leung, Qiang Liu, Yi Li, Kam Sze Tsang, Shi Dou Zhao, Danny Tat Ming Chan, Hsiang Fu ..., Cell Proliferation, 2017

Abstract Objectives MicroRNAs (miRNAs) are considered as the cellular regulators which post‐transcriptionally modulate gene expression in diverse biological processes including cell development and immunity. In this study, we investigated functions of miR‐181d in dendritic cells (DCs) ...


Deconvoluting Kinase Inhibitor Induced Cardiotoxicity

26-May-2017 | Lamore SD, Ahlberg E, Boyer S, et al., Toxicological Sciences, 2017

Abstract Many drugs designed to inhibit kinases have their clinical utility limited by cardiotoxicity-related label warnings or prescribing restrictions. While this liability is widely recognized, designing safer kinase inhibitors (KI) requires knowledge of the causative kinase(s). Efforts to ...


Autophagy plays a dual role during intracellular siRNA delivery by lipoplex and polyplex nanoparticles

22-May-2017 | Author(s): Wen Song, Zhiwei Ma, Yumei Zhang, Chuanxu Yang, Acta Biomaterialia, 2017

Publication date: Available online 17 May 2017 Source:Acta Biomaterialia Author(s): Wen Song, Zhiwei Ma, Yumei Zhang, Chuanxu Yang Growing evidence indicates that autophagy plays a vital role during the intracellular DNA delivery mediated by lipoplex and polyplex nanoparticles. ...


Caffeic acid phenethyl ester upregulates N‐myc downstream regulated gene 1 via ERK pathway to inhibit human oral cancer cell growth in vitro and in vivo

09-Feb-2017 | Li‐Chuan Chung, Kun‐Chun Chiang, Tsui‐Hsia Feng, Kang‐Shuo Chang, Sung‐Ting Chuang, Yu‐Jen Chen, Ke‐Hung Tsui, Jehn‐ ..., Molecular Nutrition & Food Research, 2017

Scope Caffeic acid phenethyl ester (CAPE), a bioactive component of propolis, is considered as a new anti‐cancer agent. Oral squamous cell carcinoma (OSCC) is the most common oral cancer with unsatisfying survival. N‐myc downstream regulated family genes (NDRGs) involve in numerous ...


Efficient tuning of siRNA dose response by combining mixed polymer nanocarriers with simple kinetic modeling

08-Jan-2017 | Author(s): Chad T. Greco, Victoria G. Muir, Thomas H. Epps III, Millicent O. Sullivan, Acta Biomaterialia, 2017

Publication date: Available online 4 January 2017 Source:Acta Biomaterialia Author(s): Chad T. Greco, Victoria G. Muir, Thomas H. Epps III, Millicent O. Sullivan Two of the most prominent challenges that limit the clinical success of siRNA therapies are a lack of control over cargo ...


NgAgo-based fabp11a gene knockdown causes eye developmental defects in zebrafish

11-Nov-2016 | Jialing Qi; Zhangji Dong; Yunwei Shi; Xin Wang; Yinyin Qin; Yongming Wang; Dong Liu, Cell Research, 2016

NgAgo-based fabp11a gene knockdown causes eye developmental defects in zebrafish Cell Research advance online publication, November 11 2016. doi:10.1038/cr.2016.134 Authors: Jialing Qi, Zhangji Dong, Yunwei Shi, Xin Wang, Yinyin Qin, Yongming Wang & Dong Liu


RNAi‐based targeted gene‐knockdown in the model oleaginous microalgae Nannochloropsis oceanica

07-Nov-2016 | Li Wei, Yi Xin, Qintao Wang, Juan Yang, Hanhua Hu, Jian Xu, The Plant Journal, 2016

Abstract Microalgae are promising feedstock for renewable fuels such as biodiesel, yet development of industrial oleaginous strains has been hindered by the paucity and inefficiency of reverse genetics tools. Here we established an efficient RNAi‐based targeted gene knockdown method for ...


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