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65 Newest Publications about the topic follicle-stimulating hormone


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Identification of two novel, alternatively spliced mRNA transcripts of the human follicle‐stimulating hormone receptor

05-Sep-2013 | Jun Zhou, Yiting Huang, Lili Li, Liang Zhu, Dan Zhang, Suzhan Zhang, Yiding Chen, Molecular Reproduction and Development, 2013

SUMMARY Glycoprotein hormone receptors contain large extracellular domains encoded by multiple exons that can be alternatively spliced. Using human ovarian surface epithelium, we cloned two new splice variants of the human follicle‐stimulating hormone receptor (FSH‐R) gene, hFSH‐R2 and ...


Clinical characteristics and treatment of azoospermia and severe oligospermia patients with Y‐chromosome microdeletions

03-Sep-2013 | Fengbin Zhang, Lejun Li, Liquan Wang, Liming Yang, Zhongyan Liang, Jingping Li, Fan Jin, Yonghong Tian, Molecular Reproduction and Development, 2013

SUMMARY Clinical characteristics, testicular pathology, serum levels of reproductive hormones, and genetic analysis were compared among 100 azoospermic, 20 oligozoospermic cases with azoospermia factor (AZF) microdeletion, and 50 fertile males to evaluate the relationship between the AZF ...


The role of brain peptides in the reproduction of blue gourami males (Trichogaster trichopterus)

15-Jul-2013 | Gal Levy, Gad Degani, Journal of Experimental Zoology Part A: Ecological Genetics and Physiology, 2013

ABSTRACT In all vertebrates, reproduction and growth are closely linked and both are controlled by complex hormonal interactions at the brain‐pituitary level. In this study, we focused on the reciprocal interactions between brain peptides that regulate growth and reproductive functions in a ...


FSH modulates the expression of inhibin‐alpha and the secretion of inhibins via orphan nuclear receptor NUR77 in ovarian granulosa cells

08-Jul-2013 | Qin‐Yuan He, Li‐Jun Ding, Hai‐Xiang Sun, Bin Yu, An‐Yi Dai, Ning‐Yuan Zhang, Bin Wang, Gui‐Jun Yan, Pei‐Zhen Xu, Ya‐ ..., Molecular Reproduction and Development, 2013

Abstract It has been previously reported that follicle‐stimulating hormone (FSH) regulates the expression of inhibin‐alpha in human granulosa cells, but the precise molecular pathway remains unknown. In the present study, we investigated the role of the orphan nuclear receptor, NUR77, in both ...


Supplemented αMEM/F12‐based medium enables the survival and growth of primary ovarian follicles encapsulated in alginate hydrogels

25-Jun-2013 | David Tagler, Yogeshwar Makanji, Nicholas R. Anderson, Teresa K. Woodruff, Lonnie D. Shea, Biotechnology and Bioengineering, 2013

Abstract Hydrogel‐encapsulating culture systems for ovarian follicles support the in vitro growth of secondary follicles from various species including mouse, non‐primate human, and human; however, the growth of early stage follicles (primary and primordial) has been limited. While ...


Developing Predictive Approaches to Characterize Adaptive Responses of the Reproductive Endocrine Axis to Aromatase Inhibition: I. Data Generation in a Small Fish Model

01-Jun-2013 | Daniel L. Villeneuve; Miyuki Breen; David C. Bencic; Jenna E. Cavallin; Kathleen M. Jensen; Elizabeth A. Makynen; Li ..., Toxicological Sciences, 2013

Adaptive or compensatory responses to chemical exposure can significantly influence in vivo concentration-duration-response relationships. This study provided data to support development of a computational dynamic model of the hypothalamic-pituitary-gonadal axis of a model vertebrate and its ...


Recombinant human follicle‐stimulating hormone and transforming growth factor‐alpha enhance in vitro maturation of porcine oocytes

10-May-2013 | Tomomi Mito, Koji Yoshioka, Michiko Noguchi, Shoko Yamashita, Hiroyoshi Hoshi, Molecular Reproduction and Development, 2013

Abstract The biological functions of recombinant human follicle‐stimulating hormone (FSH) and transforming growth factor‐α (TGF‐α) on in vitro maturation of porcine oocytes were investigated. Cumulus‐oocyte complexes were matured in defined porcine oocyte medium containing 0–0.1 IU/ml FSH in ...


An update on the use of degarelix in the treatment of advanced hormone-dependent prostate cancer

24-Apr-2013 | Rick FG, Block NL, Schally AV, OncoTargets and Therapy, 2013

Androgen deprivation therapy remains the mainstay of medical treatment for advanced prostate cancer. Commonly, this is achieved with medical androgen deprivation rather than surgical intervention as the permanence and psychological effects of the latter are unacceptable for most patients. ...


Effect of FSH Receptor Binding Inhibitor‐8 (FRBI‐8) on FSH Mediated Granulosa Cell Signaling and Proliferation

20-Apr-2013 | Rajshri M Navalakhe, Dhanshree D Jagtap, Sumeet U Nayak, Tarala D Nandedkar, Smita D Mahale, Chemical Biology & Drug Design, 2013

Abstract Follicle stimulating hormone (FSH) is important for the mammalian reproduction. It acts through specific receptors located on the plasma membrane of granulosa cells in ovaries and sertoli cells in testes. The binding of FSH to its receptor activates intra cytoplasmic signaling ...


Cost–effectiveness analysis comparing degarelix with leuprolide in hormonal therapy for patients with locally advanced prostate cancer

10-Apr-2013 | Hind T Hatoum; E David Crawford; Sandy Kildegaard Nielsen; Swu-Jane Lin; Dennis C Marshall, Expert Review of Pharmacoeconomics & Outcomes Research, 2013

Degarelix, approved in the USA in 2008, is a gonadotropin-releasing hormone antagonist, representing one of the latest additions to androgen deprivation therapy (ADT). ADT is used as first-line therapy for locally advanced or metastatic prostate cancer with the aim to reduce testosterone to ...


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