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1,234 Newest Publications about the topic embryonic stem cells


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Emerging stem cell ethics

22-Jun-2018 | Douglas Sipp; Megan Munsie; Jeremy Sugarman, Science , 2018

It has been 20 years since the first derivation of human embryonic stem cells. That milestone marked the start of a scientific and public fascination with stem cells, not just for their biological properties but also for their potentially transformative medical uses. The next two decades of stem ...


Marine Drugs, Vol. 16, Pages 192: A Novel Atypical PKC-Iota Inhibitor, Echinochrome A, Enhances Cardiomyocyte Differentiation from Mouse Embryonic Stem Cells

02-Jun-2018 | Kim, Hyoung Kyu; Cho, Sung Woo; Heo, Hye Jin; Jeong, Seung Hun; Kim, Min ; Ko, Kyung Soo; Rhee, Byoung Doo; Mi ..., Marine Drugs, 2018

Marine Drugs, Vol. 16, Pages 192: A Novel Atypical PKC-Iota Inhibitor, Echinochrome A, Enhances Cardiomyocyte Differentiation from Mouse Embryonic Stem Cells Marine Drugs doi: 10.3390/md16060192 Authors: Hyoung Kyu Kim Sung Woo Cho Hye Jin Heo Seung Hun Jeong Min Kim Kyung Soo ...


A CRISPR knockout screen identifies SETDB1-target retroelement silencing factors in embryonic stem cells [RESEARCH]

01-Jun-2018 | Fukuda, K., Okuda, A., Yusa, K., Shinkai, Y., Genome Research, 2018

In mouse embryonic stem cells (mESCs), the expression of provirus and endogenous retroelements is epigenetically repressed. Although many cellular factors involved in retroelement silencing have been identified, the complete molecular mechanism remains elusive. In this study, we performed a ...


Cell therapy trials for heart regeneration — lessons learned and future directions

09-May-2018 | Philippe Menasché, Nature Clinical Practice Cardiovascular Medicine, 2018

The effects of cell therapy on heart regeneration in patients with chronic cardiomyopathy have been assessed in several clinical trials. These trials can be categorized as those using noncardiac stem cells, including mesenchymal stem cells, and those using cardiac-committed cells, including KIT+ ...


A PAX5–OCT4–PRDM1 developmental switch specifies human primordial germ cells

30-Apr-2018 | Fang Fang; Benjamin Angulo; Ninuo Xia; Meena Sukhwani; Zhengyuan Wang; Charles C. Carey; Aurélien Mazurie; Jun ..., Nature Cell Biology, 2018

Dysregulation of genetic pathways during human germ cell development leads to infertility. Here, we analysed bona fide human primordial germ cells (hPGCs) to probe the developmental genetics of human germ cell specification and differentiation. We examined the distribution of OCT4 occupancy in ...


TFAP2C regulates transcription in human naive pluripotency by opening enhancers

25-Apr-2018 | William A. Pastor; Wanlu Liu; Di Chen; Jamie Ho; Rachel Kim; Timothy J. Hunt; Anastasia Lukianchikov; Xiaodong Liu; ..., Nature Cell Biology, 2018

Naive and primed pluripotent human embryonic stem cells bear transcriptional similarity to pre- and post-implantation epiblast and thus constitute a developmental model for understanding the pluripotent stages in human embryo development. To identify new transcription factors that differentially ...


Brd4-independence in ground state pluripotency

16-Apr-2018 | Yaser Atlasi; Hendrik G. Stunnenberg, Nature Cell Biology, 2018

Brd4-independence in ground state pluripotency Brd4-independence in ground state pluripotency, Published online: 16 April 2018; doi:10.1038/s41556-018-0099-y Brd4, a reader of histone acetylation, is a transcriptional co-activator implicated in the maintenance of embryonic stem cells (ESCs). A ...


ERF deletion rescues RAS deficiency in mouse embryonic stem cells [Research Papers]

01-Apr-2018 | Cristina Mayor-Ruiz; Teresa Olbrich; Matthias Drosten; Emilio Lecona; Maria Vega-Sendino; Sagrario Ortega; Orlando D ..., Genes & Development, 2018

MEK inhibition in combination with a glycogen synthase kinase-3β (GSK3β) inhibitor, referred as the 2i condition, favors pluripotency in embryonic stem cells (ESCs). However, the mechanisms by which the 2i condition limits ESC differentiation and whether RAS proteins are involved in this ...


HOXB7 overexpression in lung cancer is a hallmark of acquired stem-like phenotype

26-Mar-2018 | Simona Monterisi; Pietro Lo Riso; Karin Russo; Giovanni Bertalot; Manuela Vecchi; Giuseppe Testa; Pier Paolo Fiore; ..., Oncogene, 2018

HOXB7 is a homeodomain (HOX) transcription factor involved in regional body patterning of invertebrates and vertebrates. We previously identified HOXB7 within a ten-gene prognostic signature for lung adenocarcinoma, where increased expression of HOXB7 was associated with poor prognosis. This ...


Stem cells: Translating hypertranscription in embryonic stem cells

20-Mar-2018 | Kim Baumann, Nature Reviews Molecular Cell Biology, 2018

Stem cells: Translating hypertranscription in embryonic stem cells Stem cells: Translating hypertranscription in embryonic stem cells, Published online: 20 March 2018; doi:10.1038/nrm.2018.19 The decondensed, permissive chromatin state of pluripotent stem cells is sensitive to translation, ...


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