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37 Newest Publications about the topic drug tests

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Metabolic Enzymes of Cocaine Metabolite Benzoylecgonine

09-Jun-2016 | Xiabin Chen; Xirong Zheng; Max Zhan; Ziyuan Zhou; Chang-Guo Zhan; Fang Zheng, ACS Chemical Biology, 2016

Cocaine is one of the most addictive drugs without a U.S. Food and Drug Administration (FDA)-approved medication. Enzyme therapy using an efficient cocaine-metabolizing enzyme is recognized as the most promising approach to cocaine overdose treatment. The actual enzyme, known as RBP-8000, under ...

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[In Depth] As Ebola wanes, trials jockey for patients

03-Apr-2015 | Kai Kupferschmidt, Science , 2015

The Ebola epidemic in West Africa has caused enormous suffering, but scientists also see it as a chance to test experimental therapies that could save lives in the future. With declining case numbers, however,it is becoming less likely that all the drug tests will reach a conclusion. Now, ...

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Target Inhibition Networks: Predicting Selective Combinations of Druggable Targets to Block Cancer Survival Pathways

12-Sep-2013 | Jing Tang et al., PLoS Computational Biology, 2013

by Jing Tang, Leena Karhinen, Tao Xu, Agnieszka Szwajda, Bhagwan Yadav, Krister Wennerberg, Tero Aittokallio A recent trend in drug development is to identify drug combinations or multi-target agents that effectively modify multiple nodes of disease-associated networks. Such polypharmacological ...

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Presence and composition of cathinone derivatives in drug samples taken from a Drug Test Service in Spain (2010–2012)

24-Jul-2013 | Fernando Caudevilla‐Gálligo, Mireia Ventura, Blanca Iciar Indave Ruiz, Iván Fornís, Human Psychopharmacology: Clinical and Experimental, 2013

Objective The aim of this study was to describe the presence and composition of cathinone derivatives (CDs) in drug samples analyzed at a Drug Testing Service. Material and methods Data provided by the Drug Testing Service at Energy Control (a Spanish organization working in risk ...

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A novel tissue engineered three-dimensional in vitro colorectal cancer model

30-Jun-2013 | Author(s): Agata Nyga , Marilena Loizidou , Mark Emberton , Umber Cheema, Acta Biomaterialia, 2013

Publication date: August 2013 Source:Acta Biomaterialia, Volume 9, Issue 8 Author(s): Agata Nyga , Marilena Loizidou , Mark Emberton , Umber Cheema The interactions of cancer cells within a solid mass with the surrounding reactive stroma are critical for growth and progression. The ...

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Rapid and simultaneous determination of multiple classes of abused drugs and metabolites in human urine by a robust LC‐MS/MS method – application to urine drug testing in pain clinics

19-Jun-2013 | Jianmei Wang, Zhen Yang, James Lechago, Biomedical Chromatography, 2013

ABSTRACT A simple LC‐MS/MS method was developed and validated for quantitatively analyzing six classes of 26 abused drugs and metabolites in human urine: (1) illicit drugs; (2) opiates; (3) synthetic opioids; (4) sedative; (5) stimulants; and (6) γ‐aminobutyric acid analogs. All urine samples ...

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Modeling Ewing sarcoma tumors in vitro with 3D scaffolds [Engineering]

16-Apr-2013 | Eliza Li Shan Fong; Salah-Eddine Lamhamedi-Cherradi; Emily Burdett; Vandhana Ramamoorthy; Alexander J. Lazar; F. Kur ..., Proceedings of the National Academy of Sciences current issue, 2013

The pronounced biological influence of the tumor microenvironment on cancer progression and metastasis has gained increased recognition over the past decade, yet most preclinical antineoplastic drug testing is still reliant on conventional 2D cell culture systems. Although monolayer cultures ...

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Erlotinib Prolongs Survival in Pancreatic Cancer by Blocking Gemcitabine-Induced MAPK Signals

01-Apr-2013 | Koji Miyabayashi; Hideaki Ijichi; Dai Mohri; Motohisa Tada; Keisuke Yamamoto; Yoshinari Asaoka; Tsuneo Ikenoue; Keis ..., Cancer Research, 2013

Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly cancers worldwide. Although many regimens have been used for PDAC treatment, the combination of the EGF receptor (EGFR) inhibitor erlotinib with gemcitabine has been the only molecular-targeted drug tested so far that has been ...

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A thin‐walled polydimethylsiloxane bioreactor for high‐density hepatocyte sandwich culture

27-Dec-2012 | Guo‐Dong Sean Tan, Guoyang William Toh, Erik Birgersson, Jeffrey Robens, Danny Van Noort, Hwa Liang Leo, Biotechnology and Bioengineering, 2012

Abstract In vitro drug testing requires long‐term maintenance of hepatocyte liver specific functions. Hepatocytes cultured at a higher seeding density in a sandwich configuration exhibit an increased level of liver specific functions when compared to low density cultures due to the better cell ...

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Bioinspired multivalent DNA network for capture and release of cells [Engineering]

27-Nov-2012 | Weian Zhao; Cheryl H. Cui; Suman Bose; Dagang Guo; Chong Shen; Wesley P. Wong; Ken Halvorsen; Omid C. Farokhzad; Gra ..., Proceedings of the National Academy of Sciences current issue, 2012

Capture and isolation of flowing cells and particulates from body fluids has enormous implications in diagnosis, monitoring, and drug testing, yet monovalent adhesion molecules used for this purpose result in inefficient cell capture and difficulty in retrieving the captured cells. Inspired by ...

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