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1,582 Newest Publications about the topic dna repair

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Targeting the MALAT1/PARP1/LIG3 complex induces DNA damage and apoptosis in multiple myeloma

22-Mar-2018 | Yi Hu; Jianhong Lin; Hua Fang; Jing Fang; Chen Li; Wei Chen; Shuang Liu; Sarah Ondrejka; Zihua Gong; Frederic Reu; J ..., Leukemia, 2018

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a highly conserved long non-coding RNA (lncRNA). Overexpression of MALAT1 has been demonstrated to related to poor prognosis of multiple myeloma (MM) patients. Here, we demonstrated that MALAT1 plays important roles in MM DNA ...

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Overexpression of the base excision repair NTHL1 glycosylase causes genomic instability and early cellular hallmarks of cancer

07-Mar-2018 | Limpose K, Trego K, Li Z, et al., Nucleic Acids Research, 2018

Abstract Base excision repair (BER), which is initiated by DNA N-glycosylase proteins, is the frontline for repairing potentially mutagenic DNA base damage. The NTHL1 glycosylase, which excises DNA base damage caused by reactive oxygen species, is thought to be a tumor suppressor. However, in ...

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Overexpression of the base excision repair NTHL1 glycosylase causes genomic instability and early cellular hallmarks of cancer

07-Mar-2018 | Limpose K, Trego K, Li Z, et al., Nucleic Acids Research, 2018

Abstract Base excision repair (BER), which is initiated by DNA N-glycosylase proteins, is the frontline for repairing potentially mutagenic DNA base damage. The NTHL1 glycosylase, which excises DNA base damage caused by reactive oxygen species, is thought to be a tumor suppressor. However, in ...

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p53 isoforms regulate premature aging in human cells

12-Feb-2018 | Natalia Muhlinen; Izumi Horikawa; Fatima Alam; Kazunobu Isogaya; Delphine Lissa; Borek Vojtesek; David P Lane; Curti ..., Oncogene, 2018

Cellular senescence is a hallmark of normal aging and aging-related syndromes, including the premature aging disorder Hutchinson-Gilford Progeria Syndrome (HGPS), a rare genetic disorder caused by a single mutation in the LMNA gene that results in the constitutive expression of a truncated ...

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Fanconi anemia: from DNA repair to metabolism

02-Feb-2018 | Silvia Ravera; Carlo Dufour; Paolo Degan; Enrico Cappelli, European Journal of Human Genetics, 2018

Fanconi anemia: from DNA repair to metabolism Fanconi anemia: from DNA repair to metabolism, Published online: 02 February 2018; doi:10.1038/s41431-017-0046-6 Fanconi anemia: from DNA repair to metabolism

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Cytochrome c oxidase deficiency, oxidative stress, possible antioxidant therapy and link to nuclear DNA damage

02-Feb-2018 | Liza Douiev; Bassam Abu-Libdeh; Ann Saada, European Journal of Human Genetics, 2018

In response to Ravera et al. “Fanconi anemia: from DNA repair to metabolism” commenting on our recent publication by Abu-Libdeh, Douiev et al., describing a pathogenic variant in the COX 4I1 gene simulating Fanconi anemia, we wish to add supplementary, pertinent information linking cytochrome c ...

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Targeting PLK1 overcomes T-DM1 resistance via CDK1-dependent phosphorylation and inactivation of Bcl-2/xL in HER2-positive breast cancer

02-Feb-2018 | Özge Saatci; Simone Borgoni; Özge Akbulut; Selvi Durmuş; Umar Raza; Erol Eyüpoğlu; Can Alka ..., Oncogene, 2018

Trastuzumab-refractory, HER2 (human epidermal growth factor receptor 2)-positive breast cancer is commonly treated with trastuzumab emtansine (T-DM1), an antibody–drug conjugate of trastuzumab and the microtubule-targeting agent, DM1. However, drug response reduces greatly over time due to ...

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Wild-type and mutated IDH1/2 enzymes and therapy responses

25-Jan-2018 | Remco J. Molenaar; Jaroslaw P. Maciejewski; Johanna W. Wilmink; Cornelis J. F. Noorden, Oncogene, 2018

Isocitrate dehydrogenase 1 and 2 (IDH1/2) are key enzymes in cellular metabolism, epigenetic regulation, redox states, and DNA repair. IDH1/2 mutations are causal in the development and/or progression of various types of cancer due to supraphysiological production of d-2-hydroxyglutarate. In ...

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Wild-type and mutated IDH1/2 enzymes and therapy responses

25-Jan-2018 | Remco J. Molenaar; Jaroslaw P. Maciejewski; Johanna W. Wilmink; Cornelis J. F. Noorden, Oncogene, 2018

Isocitrate dehydrogenase 1 and 2 (IDH1/2) are key enzymes in cellular metabolism, epigenetic regulation, redox states, and DNA repair. IDH1/2 mutations are causal in the development and/or progression of various types of cancer due to supraphysiological production of d-2-hydroxyglutarate. In ...

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BRAP-2 promotes DNA damage induced germline apoptosis in C. elegans through the regulation of SKN-1 and AKT-1

22-Jan-2018 | Dayana R. D’Amora; Queenie Hu; Monica Pizzardi; Terrance J. Kubiseski, Cell Death and Differentiation, 2018

As part of the DNA damage response (DDR) network, the tumour suppressor Breast cancer susceptibility gene 1 (BRCA1) is activated to facilitate DNA repair, transcription and cell cycle control. BRC-1, the Caenorhabditis elegans ortholog of BRCA1, has conserved function in DNA double strand break ...

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