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1,582 Newest Publications about the topic dna repair


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Cisplatin-DNA adduct repair of transcribed genes is controlled by two circadian programs in mouse tissues [Biochemistry]

22-May-2018 | Yanyan Yang; Ogun Adebali; Gang Wu; Christopher P. Selby; Yi-Ying Chiou; Naim Rashid; Jinchuan Hu; John B. Hogenesch ..., Proceedings of the National Academy of Sciences current issue, 2018

Cisplatin is a front-line drug in treatment of most solid tissue cancers. It kills cancer cells by damaging their DNA. Although it is quite effective it has two major drawbacks. First, it has serious side effects, including nephrotoxicity, hepatotoxicity, and neurotoxicity. Secondly, some cancers ...


Biochemical characterization of RecBCD enzyme from an Antarctic Pseudomonas species and identification of its cognate Chi (χ) sequence

18-May-2018 | Theetha L. Pavankumar; Anurag K. Sinha; Malay K. Ray, PLoS ONE, 2018

by Theetha L. Pavankumar, Anurag K. Sinha, Malay K. Ray Pseudomonas syringae Lz4W RecBCD enzyme, RecBCDPs, is a trimeric protein complex comprised of RecC, RecB, and RecD subunits. RecBCD enzyme is essential for P. syringae growth at low temperature, and it protects cells from low temperature ...


Mechanism for survival of homozygous nonsense mutations in the tumor suppressor gene BRCA1 [Genetics]

15-May-2018 | Aaron Seo; Orna Steinberg-Shemer; Sule Unal; Silvia Casadei; Tom Walsh; Fatma Gumruk; Stavit Shalev; Akiko Shimamura ..., Proceedings of the National Academy of Sciences current issue, 2018

Many patients with breast and ovarian cancer carry inherited cancer-predisposing mutations in BRCA1 . However, virtually no patients have two inherited mutations in BRCA1 because the DNA repair function of BRCA1 is essential for embryonic development. We discovered that patients with two nonsense ...


Atherosclerosis linked to faulty DNA repair in VSMCs

09-May-2018 | Caroline Barranco, Nature Clinical Practice Cardiovascular Medicine, 2018

Atherosclerosis linked to faulty DNA repair in VSMCs Atherosclerosis linked to faulty DNA repair in VSMCs, Published online: 09 May 2018; doi:10.1038/s41569-018-0021-0 Atherosclerosis linked to faulty DNA repair in VSMCs


Pharmacogenetics of platinum-based chemotherapy: impact of DNA repair and folate metabolism gene polymorphisms on prognosis of non-small cell lung cancer patients

17-Apr-2018 | Cristina Pérez-Ramírez; Marisa Cañadas-Garre; Ahmed Alnatsha; Eduardo Villar; Javier Valdivia-Bautist ..., The Pharmacogenomics Journal, 2018

Chemotherapy based on platinum compounds is the standard treatment for NSCLC patients with EGFR wild type, and is also used as second line in mutated EGFR patients. Nevertheless, this therapy presents poor clinical outcomes. ERCC1, ERCC2, XRCC1, MDM2, MTHFR, MTR, and SLC19A1 gene polymorphisms ...


Defining essential genes for human pluripotent stem cells by CRISPR–Cas9 screening in haploid cells

16-Apr-2018 | Atilgan Yilmaz; Mordecai Peretz; Aviram Aharony; Ido Sagi; Nissim Benvenisty, Nature Cell Biology, 2018

The maintenance of pluripotency requires coordinated expression of a set of essential genes. Using our recently established haploid human pluripotent stem cells (hPSCs), we generated a genome-wide loss-of-function library targeting 18,166 protein-coding genes to define the essential genes in ...


Crystal structure of the novel lesion-specific endonuclease PfuEndoQ from Pyrococcus furiosus

12-Apr-2018 | Miyazono K, Ishino S, Makita N, et al., Nucleic Acids Research, 2018

Abstract Because base deaminations, which are promoted by high temperature, ionizing radiation, aerobic respiration and nitrosative stress, produce mutations during replication, deaminated bases must be repaired quickly to maintain genome integrity. Recently, we identified a novel lesion-specific ...


The coming of age of chaperone-mediated autophagy

06-Apr-2018 | Susmita Kaushik; Ana Maria Cuervo, Nature Reviews Molecular Cell Biology, 2018

Chaperone-mediated autophagy (CMA) was the first studied process that indicated that degradation of intracellular components by the lysosome can be selective — a concept that is now well accepted for other forms of autophagy. Lysosomes can degrade cellular cytosol in a nonspecific manner but can ...


cAMP-independent non-pigmentary actions of variant melanocortin 1 receptor: AKT-mediated activation of protective responses to oxidative DNA damage

06-Apr-2018 | María Castejón-Griñán; Cecilia Herraiz; Conchi Olivares; Celia Jiménez-Cervantes; Jose Carl ..., Oncogene, 2018

The melanocortin 1 receptor gene (MC1R), a well-established melanoma susceptibility gene, regulates the amount and type of melanin pigments formed within epidermal melanocytes. MC1R variants associated with increased melanoma risk promote the production of photosensitizing pheomelanins as opposed ...


The long tail of oncogenic drivers in prostate cancer

02-Apr-2018 | Joshua Armenia; Stephanie A. M. Wankowicz; David Liu; Jianjiong Gao; Ritika Kundra; Ed Reznik; Walid K. Chatila; Deb ..., Nature Genetics, 2018

Comprehensive genomic characterization of prostate cancer has identified recurrent alterations in genes involved in androgen signaling, DNA repair, and PI3K signaling, among others. However, larger and uniform genomic analysis may identify additional recurrently mutated genes at lower ...


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