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1,582 Newest Publications about the topic dna repair

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Altered circadian genes expression in breast cancer tissue according to the clinical characteristics

29-Jun-2018 | Monika Lesicka; Ewa Jabłońska; Edyta Wieczorek; Barbara Seroczyńska; Anna Siekierzycka; Jarosław Skokowski; Leszek K ..., PLoS ONE, 2018

by Monika Lesicka, Ewa Jabłońska, Edyta Wieczorek, Barbara Seroczyńska, Anna Siekierzycka, Jarosław Skokowski, Leszek Kalinowski, Wojciech Wąsowicz, Edyta Reszka Breast cancer has a multifactorial etiology. One of the supposed and novel mechanisms is an alteration of circadian gene expression. ...

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Electronic cigarette aerosols induce DNA damage and reduce DNA repair: Consistency across species [Biological Sciences]

12-Jun-2018 | Lurdes Queimado; Theodore Wagener; Vengatesh Ganapathy, Proceedings of the National Academy of Sciences current issue, 2018

We read with great interest the work of Lee et al. (1), in which the authors report that mice exposed to electronic cigarette aerosol have increased levels of DNA lesions and decreased DNA repair activity. This work sparked important discussion both in PNAS (2, 3) and science media (4). We do ...

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Reply to Queimado et al.: E-cigarettes induce DNA damage and inhibit DNA repair in mice and human cells [Biological Sciences]

12-Jun-2018 | Moon-shong Tang, Proceedings of the National Academy of Sciences current issue, 2018

We believe that Queimado et al. (1) may have inadvertently missed several key details presented in our recent PNAS publication (2). First, for the determination of nicotine effects on DNA adduct formation and DNA repair activity, the nicotine concentrations used for 1-h treatments of human lung ...

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DNA-bound ubiquitin coordinates repair

08-Jun-2018 | Stella Hurtley; Leslie K. Ferrarelli, Science , 2018

DNA Repair Ubiquitylation is a posttranslational modification that reversibly alters various protein properties. Liu et al. discovered that Lys63-linked polyubiquitin chains bound to the free ends of double-stranded DNA, bridged the broken ends of DNA, and recruited repair proteins. Ubiquitins ...

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The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans

07-Jun-2018 | Ye Hong; Maria Velkova; Nicola Silva; Marlène Jagut; Viktor Scheidt; Karim Labib; Verena Jantsch; Anton Gartner, PLoS Genetics, 2018

by Ye Hong, Maria Velkova, Nicola Silva, Marlène Jagut, Viktor Scheidt, Karim Labib, Verena Jantsch, Anton Gartner Homologous recombination is essential for crossover (CO) formation and accurate chromosome segregation during meiosis. It is of considerable importance to work out how ...

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A mutational co-occurrence network in gastric cancer based on an association index

06-Jun-2018 | Sungjin Park; Seungyoon Nam, International Journal of Data Mining and Bioinformatics, 2018

A mutational co-occurrence network in gastric cancer based on an association indexSungjin Park; Seungyoon NamInternational Journal of Data Mining and Bioinformatics, Vol. 20, No. 1 (2018) pp. 67 - 76Gastric cancer (GC) is one of the most lethal, as well as one of the heterogeneous, cancer types. ...

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Variable termination sites of DNA polymerases encountering a DNA–protein cross-link

01-Jun-2018 | Anna V. Yudkina; Antonina P. Dvornikova; Dmitry O. Zharkov, PLoS ONE, 2018

by Anna V. Yudkina, Antonina P. Dvornikova, Dmitry O. Zharkov DNA-protein cross-links (DPCs) are important DNA lesions induced by endogenous crosslinking agents such as formaldehyde or acetaldehyde, as well as ionizing radiation, cancer chemotherapeutic drugs, and abortive action of some ...

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Separable roles for Mec1/ATR in genome maintenance, DNA replication, and checkpoint signaling [Research Papers]

01-Jun-2018 | Michael Charles Lanz; Susannah Oberly; Ethan James Sanford; Sushma Sharma; Andrei Chabes; Marcus Bustamante Smolka, Genes & Development, 2018

The Mec1/ATR kinase coordinates multiple cellular responses to replication stress. In addition to its canonical role in activating the checkpoint kinase Rad53, Mec1 also plays checkpoint-independent roles in genome maintenance that are not well understood. Here we used a combined ...

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PARP1 depletion improves mitochondrial and heart function in Chagas disease: Effects on POLG dependent mtDNA maintenance

31-May-2018 | Jake Jianjun Wen; Yuhui Whitney Yin; Nisha Jain Garg, PLoS Pathogens, 2018

by Jake Jianjun Wen, Yuhui Whitney Yin, Nisha Jain Garg Chagasic cardiomyopathy is caused by Trypanosoma cruzi infection. Poly(ADP-ribose) polymerase 1 (PARP1) is known for its function in nuclear DNA repair. In this study, we have employed genetic deletion and chemical inhibition approaches to ...

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Elevated Nrf-2 responses are insufficient to mitigate protein carbonylation in hepatospecific PTEN deletion mice

25-May-2018 | Dennis R. Petersen; Laura M. Saba; Volkan I. Sayin; Thales Papagiannakopoulos; Edward E. Schmidt; Gary F. Merrill; D ..., PLoS ONE, 2018

by Dennis R. Petersen, Laura M. Saba, Volkan I. Sayin, Thales Papagiannakopoulos, Edward E. Schmidt, Gary F. Merrill, David J. Orlicky, Colin T. Shearn Objective In the liver, a contributing factor in the pathogenesis of non-alcoholic fatty liver disease (NASH) is oxidative stress, which leads ...

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