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16,695 Newest Publications about the topic diseases

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T-type calcium channels in the orbitofrontal cortex mediate sensory integration as measured using a spontaneous oddity task in rats [RESEARCH]

01-Jul-2018 | Wendie N. Marks; Madeline E. Parker; Nadine K. Zabder; Quentin Greba; Terrance P. Snutch; John G. Howland, Learning & Memory, 2018

The roles of low-voltage-activated (T-type) calcium channels in brain diseases have been studied extensively. Less is known regarding the involvement of T-type channels in cognition and behavior. Sensory integration (SI) is a cognitive process whereby the brain uses unimodal or multimodal sensory ...

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A survey of predictive analytics using big data with data mining

29-Jun-2018 | S. Poornima; M. Pushpalatha, International Journal of Bioinformatics Research and Applications, 2018

A survey of predictive analytics using big data with data miningS. Poornima; M. PushpalathaInternational Journal of Bioinformatics Research and Applications, Vol. 14, No. 3 (2018) pp. 269 - 282Today, the world is filled with data like Oxygen. The amount of data being harvested and eaten up is ...

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Potential of photoplethysmogram for the detection of calcification and stenosis in lower limb

29-Jun-2018 | Neelamshobha Nirala; R. Periyasamy; Awanish Kumar, International Journal of Bioinformatics Research and Applications, 2018

Potential of photoplethysmogram for the detection of calcification and stenosis in lower limbNeelamshobha Nirala; R. Periyasamy; Awanish KumarInternational Journal of Bioinformatics Research and Applications, Vol. 14, No. 3 (2018) pp. 283 - 304Early detection of arterial stiffness (AS) and ...

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Connecting neuronal circuits for movement

29-Jun-2018 | Silvia Arber; Rui M. Costa, Science , 2018

Movement is the most common final output of nervous system activity and is essential for survival. But what makes this seemingly trivial statement so scientifically challenging? Neurons that contribute to when and how our body moves are distributed throughout the nervous system. Thus, even a ...

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Viruses, Vol. 10, Pages 345: Delivering Phage Products to Combat Antibiotic Resistance in Developing Countries: Lessons Learned from the HIV/AIDS Epidemic in Africa

27-Jun-2018 | Nagel, Tobi E., Viruses, 2018

Viruses, Vol. 10, Pages 345: Delivering Phage Products to Combat Antibiotic Resistance in Developing Countries: Lessons Learned from the HIV/AIDS Epidemic in Africa Viruses doi: 10.3390/v10070345 Authors: Tobi E. Nagel The antimicrobial resistance (AMR) crisis and HIV/AIDS epidemic ...

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QnAs with Rafael Radi [QnAs]

26-Jun-2018 | Sandeep Ravindran, Proceedings of the National Academy of Sciences current issue, 2018

Rafael Radi has received numerous awards for his work on free radicals, oxidants, and reduction/oxidation pathways in biomedicine. During a long and fruitful career, he has characterized the formation and chemistry of peroxynitrite, including its role in mitochondrial dysfunction, pathology, and ...

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CHD4 and the NuRD complex directly control cardiac sarcomere formation [Developmental Biology]

26-Jun-2018 | Caralynn M. Wilczewski; Austin J. Hepperla; Takashi Shimbo; Lauren Wasson; Zachary L. Robbe; Ian J. Davis; Paul A. W ..., Proceedings of the National Academy of Sciences current issue, 2018

Birth defects are the leading cause of infant mortality in the United States and Europe, with cardiac defects being the most prevalent. Here we define the requirement and mechanism of action of CHD4, the catalytic core component of the nucleosome remodeling and deacetylase (NuRD) complex, in ...

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All-atom simulations disentangle the functional dynamics underlying gene maturation in the intron lariat spliceosome [Biophysics and Computational Biology]

26-Jun-2018 | Lorenzo Casalino; Giulia Palermo; Angelo Spinello; Ursula Rothlisberger; Alessandra Magistrato, Proceedings of the National Academy of Sciences current issue, 2018

Precursor messenger RNA (pre-mRNA) splicing is a crucial step of gene expression, enabling the maturation of pre-mRNA transcripts into protein-coding mRNAs. In humans, a majestic ribonucleoprotein machinery—the spliceosome—governs this fundamental process, the defects and misregulation of which ...

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Enhanced mRNA delivery into lymphocytes enabled by lipid-varied libraries of charge-altering releasable transporters [Chemistry]

26-Jun-2018 | Colin J. McKinlay; Nancy L. Benner; Ole A. Haabeth; Robert M. Waymouth; Paul A. Wender, Proceedings of the National Academy of Sciences current issue, 2018

The transfection of lymphocytes with genetic material is a significant unmet need in immunotherapy and the treatment of many diseases. Current transfection strategies primarily rely on physical methods that must be conducted ex vivo and are often inefficient. We identified mixtures of ...

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Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNF{alpha}-mediated apoptosis [Cell Biology]

26-Jun-2018 | Palak Amin; Marcus Florez; Ayaz Najafov; Heling Pan; Jiefei Geng; Dimitry Ofengeim; Slawomir A. Dziedzic; Huibing Wa ..., Proceedings of the National Academy of Sciences current issue, 2018

This study demonstrates a distinct mode of RIPK1 activation mediated by a detergent-insoluble, highly ubiquitinated, activated RIPK1 species (iuRIPK1) which functions as a critical intermediate between TNF-receptor-associated complex I and assembly of the cytosolic caspase activation platform ...

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