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3,591 Newest Publications about the topic cytokines


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SUMO2 and SUMO3 redundantly prevent a noncanonical type I interferon response [Immunology and Inflammation]

26-Jun-2018 | John T. Crowl; Daniel B. Stetson, Proceedings of the National Academy of Sciences current issue, 2018

Type I interferons (IFNs) are cytokines that are essential for host defense against virus infection, but when they are inappropriately produced, they can cause severe autoimmune disease in humans. We have found that the sumoylation pathway of protein modification is essential for preventing an ...


Pharmaceuticals, Vol. 11, Pages 64: Insights into Macrophage Heterogeneity and Cytokine-Induced Neuroinflammation in Major Depressive Disorder

25-Jun-2018 | Dey, Adwitia ; Hankey Giblin, Pamela A., Pharmaceuticals, 2018

Pharmaceuticals, Vol. 11, Pages 64: Insights into Macrophage Heterogeneity and Cytokine-Induced Neuroinflammation in Major Depressive Disorder Pharmaceuticals doi: 10.3390/ph11030064 Authors: Adwitia Dey Pamela A. Hankey Giblin Over 350 million individuals suffer from depression, ...


Cell-intrinsic regulation of murine epidermal Langerhans cells by protein S [Immunology and Inflammation]

19-Jun-2018 | Yaara Tabib; Nora S. Jaber; Maria Nassar; Tal Capucha; Gabriel Mizraji; Tsipora Nir; Noam Koren; Itay Aizenbud; Avra ..., Proceedings of the National Academy of Sciences current issue, 2018

Langerhans cells (LCs) are the exclusive antigen-presenting cells of the epidermis, capable of mounting immunity and tolerance. LCs maintain themselves locally by self-renewing throughout life, a process that is regulated by both LCs and keratinocytes. Nevertheless, the mechanisms underlying this ...


Induction of CD4 T cell memory by local cellular collectivity

15-Jun-2018 | Michal Polonsky; Jacob Rimer; Amos Kern-Perets; Irina Zaretsky; Stav Miller; Chamutal Bornstein; Eyal David; Naama M ..., Science , 2018

The balance between effector and central memory T cells shifts toward the latter as the number of T cells participating in immune responses increases. Polonsky et al. determined the mechanisms by which T cell quorum sensing affects memory differentiation by using live-cell imaging to track cell ...


Activated integrins identify functional antigen-specific CD8+ T cells within minutes after antigen stimulation [Immunology and Inflammation]

12-Jun-2018 | Stoyan Dimitrov; Cécile Gouttefangeas; Luciana Besedovsky; Anja T. R. Jensen; P. Anoop Chandran; Elisa Rusch; Ramona ..., Proceedings of the National Academy of Sciences current issue, 2018

Assessing antigen-specific T cells is crucial for our understanding of immune reactions against pathogens and tumors, and for evaluating immunotherapies in patients. Existing techniques to evaluate the functionality of T lymphocytes all rely on de novo expression of proteins, typically ...


Genetic ancestry and population differences in levels of inflammatory cytokines in women: Role for evolutionary selection and environmental factors

07-Jun-2018 | Song Yao; Chi-Chen Hong; Edward A. Ruiz-Narváez; Sharon S. Evans; Qianqian Zhu; Beverly A. Schaefer; Li Yan; Marie V ..., PLoS Genetics, 2018

by Song Yao, Chi-Chen Hong, Edward A. Ruiz-Narváez, Sharon S. Evans, Qianqian Zhu, Beverly A. Schaefer, Li Yan, Marie V. Coignet, Kathryn L. Lunetta, Lara E. Sucheston-Campbell, Kelvin Lee, Elisa V. Bandera, Melissa A. Troester, Lynn Rosenberg, Julie R. Palmer, Andrew F. Olshan, Christine B. ...


Repurposing of sodium valproate in colon cancer associated with diabetes mellitus: Role of HDAC inhibition

03-Jun-2018 | Author(s): Mayur M. Patel, Bhoomika M. Patel, European Journal of Pharmaceutical Science, 2018

Publication date: 30 August 2018 Source:European Journal of Pharmaceutical Sciences, Volume 121 Author(s): Mayur M. Patel, Bhoomika M. Patel Background and purpose Diabetic patients are at greater risk for colon cancer. Histone deacetylases (HDACs) serve as common target for both. The ...


[Molecular Biology] Cytokines and Long Noncoding RNAs

01-Jun-2018 | Susan Carpenter; Katherine A. Fitzgerald, CSH Perspectives, 2018

Cytokines and long noncoding RNAs (lncRNAs) are intertwined in the regulatory circuit controlling immunity. lncRNA expression levels are altered following cytokine stimulation in a cell-type-specific fashion. lncRNAs, in turn, regulate the inducible expression of cytokines following immune ...


[Molecular Pathology] Role of the {beta} Common ({beta}c) Family of Cytokines in Health and Disease

01-Jun-2018 | Timothy R. Hercus; Winnie L. T. Kan; Sophie E. Broughton; Denis Tvorogov; Hayley S. Ramshaw; Jarrod J. Sandow; Tracy ..., CSH Perspectives, 2018

The β common ([βc]/CD131) family of cytokines comprises granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3, and IL-5, all of which use βc as their key signaling receptor subunit. This is a prototypic signaling subunit-sharing cytokine family that has unveiled many ...


Enhanced survival following oral and systemic Salmonella enterica serovar Typhimurium infection in polymeric immunoglobulin receptor knockout mice

01-Jun-2018 | Kristina J. Betz; Elizabeth A. Maier; Surya Amarachintha; David Wu; Erik P. Karmele; Jeremy M. Kinder; Kris A. Stein ..., PLoS ONE, 2018

by Kristina J. Betz, Elizabeth A. Maier, Surya Amarachintha, David Wu, Erik P. Karmele, Jeremy M. Kinder, Kris A. Steinbrecher, Monica M. McNeal, Deborah H. Luzader, Simon P. Hogan, Sean R. Moore Background Polymeric immunoglobulin receptor (pIgR) transport of secretory immunoglobulin A (SIgA) ...


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