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453 Newest Publications about the topic crispr

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MicroRNA-focused CRISPR-Cas9 library screen reveals fitness-associated miRNAs [ARTICLE]

01-Jul-2018 | Jessica S. Kurata; Ren-Jang Lin, RNA, 2018

MicroRNAs (miRNAs) are post-transcriptional gene regulators that play important roles in the control of cell fitness, differentiation, and development. The CRISPR-Cas9 gene-editing system is composed of the Cas9 nuclease in complex with a single guide RNA (sgRNA) and directs DNA cleavage at a ...

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Staphylococcus aureus targets the purine salvage pathway to kill phagocytes [Microbiology]

26-Jun-2018 | Volker Winstel; Dominique Missiakas; Olaf Schneewind, Proceedings of the National Academy of Sciences current issue, 2018

Immune evasion by the human pathogen Staphylococcus aureus includes the synthesis of cytotoxic deoxyadenosine (dAdo) from neutrophil extracellular traps to eliminate macrophages. The signaling pathway that triggers dAdo-mediated apoptosis in macrophages is not known. By using a genome-wide ...

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Neanderthal brain organoids come to life

22-Jun-2018 | Jon Cohen, Science , 2018

Scientists for the first time have grown Neanderthal "minibrains" in lab dishes. A team led by geneticist Alysson Muotri at the University of California, San Diego, reported at a conference that with the help of the genome editor CRISPR they modified a stem cell to have a Neanderthal version of a ...

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Flap endonuclease 1 is involved in cccDNA formation in the hepatitis B virus

21-Jun-2018 | Kouichi Kitamura; Lusheng Que; Miyuki Shimadu; Miki Koura; Yuuki Ishihara; Kousho Wakae; Takashi Nakamura; Koichi Wa ..., PLoS Pathogens, 2018

by Kouichi Kitamura, Lusheng Que, Miyuki Shimadu, Miki Koura, Yuuki Ishihara, Kousho Wakae, Takashi Nakamura, Koichi Watashi, Takaji Wakita, Masamichi Muramatsu Hepatitis B virus (HBV) is one of the major etiological pathogens for liver cirrhosis and hepatocellular carcinoma. Chronic HBV ...

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Viruses, Vol. 10, Pages 335: Phage Genetic Engineering Using CRISPR–Cas Systems

19-Jun-2018 | Hatoum-Aslan, Asma, Viruses, 2018

Viruses, Vol. 10, Pages 335: Phage Genetic Engineering Using CRISPR–Cas Systems Viruses doi: 10.3390/v10060335 Authors: Asma Hatoum-Aslan Since their discovery over a decade ago, the class of prokaryotic immune systems known as CRISPR–Cas have afforded a suite of genetic ...

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CRISPR-Cas antimicrobials: Challenges and future prospects

14-Jun-2018 | Elizabeth Pursey; David Sünderhauf; William H. Gaze; Edze R. Westra; Stineke van Houte, PLoS Pathogens, 2018

by Elizabeth Pursey, David Sünderhauf, William H. Gaze, Edze R. Westra, Stineke van Houte

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Consequences of resistance evolution in a Cas9-based sex conversion-suppression gene drive for insect pest management [Applied Biological Sciences]

12-Jun-2018 | Mohammad KaramiNejadRanjbar; Kolja N. Eckermann; Hassan M. M. Ahmed; Héctor M. Sánchez C.; Stefan Dippel; John M. Ma ..., Proceedings of the National Academy of Sciences current issue, 2018

Resistance evolution caused by CRISPR/Cas9 gene-drive systems has a major impact on both the future scientific design of such gene-drive systems and on the politics of regulating experimentation and use of such systems. In our study, we show that in-frame drive-resistant alleles can be produced ...

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News at a glance

08-Jun-2018 | American Association for the Advancement of Science, Science , 2018

SCI COMMUNIn science news around the world, Virginijus Šikšnys, whose role in the invention of the revolutionary genome editor CRISPR has often been overlooked, receives some vindication when he is named a co-winner of the prestigious Kavli Prize in Nanoscience. A Texas foundation gives $20 ...

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Systematic prediction of genes functionally linked to CRISPR-Cas systems by gene neighborhood analysis [Biophysics and Computational Biology]

05-Jun-2018 | Sergey A. Shmakov; Kira S. Makarova; Yuri I. Wolf; Konstantin V. Severinov; Eugene V. Koonin, Proceedings of the National Academy of Sciences current issue, 2018

The CRISPR-Cas systems that mediate adaptive immunity in bacteria and archaea encompass a small set of core cas genes that are essential in diverse systems belonging to the same subtype, type, or class. However, a much greater number of genes only sporadically co-occur with CRISPR-Cas, and for ...

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Correction for Lemos et al., CRISPR/Cas9 cleavages in budding yeast reveal templated insertions and strand-specific insertion/deletion profiles [Correction]

05-Jun-2018 | National Academy of Sciences, Proceedings of the National Academy of Sciences current issue, 2018

GENETICS Correction for “CRISPR/Cas9 cleavages in budding yeast reveal templated insertions and strand-specific insertion/deletion profiles,” by Brenda R. Lemos, Adam C. Kaplan, Ji Eun Bae, Alexander E. Ferrazzoli, James Kuo, Ranjith P. Anand, David P. Waterman, and James E. Haber, which was ...

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