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238 Newest Publications about the topic chronic lymphocytic leukemia

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The reference epigenome and regulatory chromatin landscape of chronic lymphocytic leukemia

21-May-2018 | Renée Beekman; Vicente Chapaprieta; Núria Russiñol; Roser Vilarrasa-Blasi; Núria Verdaguer-Dot; ..., Nature Medicine, 2018

Chronic lymphocytic leukemia (CLL) is a frequent hematological neoplasm in which underlying epigenetic alterations are only partially understood. Here, we analyze the reference epigenome of seven primary CLLs and the regulatory chromatin landscape of 107 primary cases in the context of normal B ...

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Ibrutinib for bridging to allogeneic hematopoietic cell transplantation in patients with chronic lymphocytic leukemia or mantle cell lymphoma: a study by the EBMT Chronic Malignancies and Lymphoma Working Parties

04-May-2018 | Peter Dreger; Mauricette Michallet; Paul Bosman; Sascha Dietrich; Mohamad Sobh; Ariane Boumendil; Arnon Nagler; Chri ..., Bone Marrow Transplantation, 2018

The aim of this retrospective study was to investigate the safety and efficacy of allogeneic hematopoietic cell transplantation (alloHCT) in patients pre-treated with ibrutinib. Eligible were patients aged >18 years allotransplanted for chronic lymphocytic leukemia (CLL) or mantle cell lymphoma ...

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p66Shc deficiency enhances CXCR4 and CCR7 recycling in CLL B cells by facilitating their dephosphorylation-dependent release from β-arrestin at early endosomes

12-Jan-2018 | Laura Patrussi; Nagaja Capitani; Francesca Cattaneo; Noemi Manganaro; Alessandra Gamberucci; Federica Frezzato; Vero ..., Oncogene, 2018

Neoplastic cell traffic abnormalities are central to the pathogenesis of chronic lymphocytic leukemia (CLL). Enhanced CXC chemokine receptor-4 (CXCR4) and chemokine receptor-7 (CCR7) recycling contributes to the elevated surface levels of these receptors on CLL cells. Here we have addressed the ...

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MicroRNA dysregulation to identify therapeutic target combinations for chronic lymphocytic leukemia [Medical Sciences]

03-Oct-2017 | Laura Z. Rassenti; Veronica Balatti; Emanuela M. Ghia; Alexey Palamarchuk; Luisa Tomasello; Paolo Fadda; Yuri Pekars ..., Proceedings of the National Academy of Sciences current issue, 2017

Loss of miR-15/16 is the most common genetic lesion in chronic lymphocytic leukemia (CLL), promoting overexpression of BCL2, which factors in leukemia pathogenesis. Indeed, an inhibitor of Bcl2, venetoclcax, is highly active in the treatment of patients with CLL. However, single-agent venetoclcax ...

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MicroRNA dysregulation to identify therapeutic target combinations for chronic lymphocytic leukemia [Medical Sciences]

03-Oct-2017 | Laura Z. Rassenti; Veronica Balatti; Emanuela M. Ghia; Alexey Palamarchuk; Luisa Tomasello; Paolo Fadda; Yuri Pekars ..., Proceedings of the National Academy of Sciences current issue, 2017

Loss of miR-15/16 is the most common genetic lesion in chronic lymphocytic leukemia (CLL), promoting overexpression of BCL2, which factors in leukemia pathogenesis. Indeed, an inhibitor of Bcl2, venetoclcax, is highly active in the treatment of patients with CLL. However, single-agent venetoclcax ...

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Aberrant levels of SUV39H1 and SUV39H2 methyltransferase are associated with genomic instability in chronic lymphocytic leukemia

19-Aug-2017 | Juliana Carvalho Alves‐Silva, Doralina do Amaral Rabello, Martha Oliveira Bravo, Antônio Roberto Lucena‐Araujo, Dieg ..., Environmental and Molecular Mutagenesis, 2017

Chromosomal alterations are commonly detected in patients with chronic lymphocytic leukemia (CLL) and impact disease pathogenesis, prognosis, and progression. Telomerase expression (hTERT), its activity and the telomere length are other important predictors of survival and multiple outcomes in ...

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Early, risk-adapted treatment with fludarabine in Binet stage A chronic lymphocytic leukemia patients: results of the CLL1 trial of the German CLL study group

14-Aug-2017 | M A Hoechstetter; R Busch; B Eichhorst; A Bühler; D Winkler; M J Eckart; U Vehling-Kaiser; H Schimke; U Jä ..., Leukemia, 2017

Early, risk-adapted treatment with fludarabine in Binet stage A chronic lymphocytic leukemia patients: results of the CLL1 trial of the German CLL study group Leukemia advance online publication, September 15 2017. doi:10.1038/leu.2017.246 Authors: M A Hoechstetter, R Busch, B ...

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Early, risk-adapted treatment with fludarabine in Binet stage A chronic lymphocytic leukemia patients: results of the CLL1 trial of the German CLL study group

14-Aug-2017 | M A Hoechstetter; R Busch; B Eichhorst; A Bühler; D Winkler; M J Eckart; U Vehling-Kaiser; H Schimke; U Jä ..., Leukemia, 2017

Early, risk-adapted treatment with fludarabine in Binet stage A chronic lymphocytic leukemia patients: results of the CLL1 trial of the German CLL study group Leukemia advance online publication, September 15 2017. doi:10.1038/leu.2017.246 Authors: M A Hoechstetter, R Busch, B ...

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Messaging with RNAs

04-Aug-2017 | Anand Balasubramani, Science , 2017

Cancer Understanding interactions between tumor cells and immune cells is essential for tailoring immunocentric therapies to tumors. Haderk et al. identified a key role for tumor-derived exosomes in modulating immune responses to chronic lymphocytic leukemia (CLL). CLL-derived exosomal RNAs ...

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Blockage of Wnt/β‐Catenin Signaling by Nanoparticles Reduces Survival and Proliferation of CLL Cells In Vitro—Preliminary Study

01-Aug-2017 | Ida Franiak‐Pietryga, Henryk Maciejewski, Barbara Ziemba, Dietmar Appelhans, Brigitte Voit, Tadeusz Robak, Magdalena ..., Macromolecular Bioscience, 2017

The Wnt/β‐catenin signaling pathway is shown to play a significant role in the control of the survival, proliferation, and differentiation of hematopoietic cells. Studies have confirmed that aberrant activation of canonical Wnt signaling occurs in various forms of leukemia, and is crucial for ...

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