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510 Newest Publications about the topic chronic inflammation

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Safer anti-inflammatory therapy through dual COX-2/5-LOX inhibitors: A structure-based approach

24-Jun-2018 | Author(s): Jaismy Jacob P, S.L. Manju, K.R. Ethiraj, Geetha Elias, European Journal of Pharmaceutical Science, 2018

Publication date: 30 August 2018 Source:European Journal of Pharmaceutical Sciences, Volume 121 Author(s): Jaismy Jacob P, S.L. Manju, K.R. Ethiraj, Geetha Elias Inflammatory mediators of the arachidonic acid cascade from cyclooxygenase (COX) and lipoxygenase (LOX) pathways are ...

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Genetic ancestry and population differences in levels of inflammatory cytokines in women: Role for evolutionary selection and environmental factors

07-Jun-2018 | Song Yao; Chi-Chen Hong; Edward A. Ruiz-Narváez; Sharon S. Evans; Qianqian Zhu; Beverly A. Schaefer; Li Yan; Marie V ..., PLoS Genetics, 2018

by Song Yao, Chi-Chen Hong, Edward A. Ruiz-Narváez, Sharon S. Evans, Qianqian Zhu, Beverly A. Schaefer, Li Yan, Marie V. Coignet, Kathryn L. Lunetta, Lara E. Sucheston-Campbell, Kelvin Lee, Elisa V. Bandera, Melissa A. Troester, Lynn Rosenberg, Julie R. Palmer, Andrew F. Olshan, Christine B. ...

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Proinflammatory enzyme soluble epoxide hydrolase bridges obesity to colonic inflammation and potential carcinogenesis [Pharmacology]

05-Jun-2018 | Guang-Yu Yang, Proceedings of the National Academy of Sciences current issue, 2018

Obesity and chronic inflammation are two well-recognized risk factors for the development of colorectal cancer (CRC). In PNAS, Wang et al. (1) use lipidomic profiling analysis to identify a significant mechanistic link between obesity and colonic inflammation via enhancing the proinflammatory ...

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Cytomegalovirus establishes a latent reservoir and triggers long-lasting inflammation in the eye

31-May-2018 | Valentina Voigt; Christopher E. Andoniou; Iona S. Schuster; Anna Oszmiana; Monique L. Ong; Peter Fleming; John V. Fo ..., PLoS Pathogens, 2018

by Valentina Voigt, Christopher E. Andoniou, Iona S. Schuster, Anna Oszmiana, Monique L. Ong, Peter Fleming, John V. Forrester, Mariapia A. Degli-Esposti Recent outbreaks of Ebola and Zika have highlighted the possibility that viruses may cause enduring infections in tissues like the eye, ...

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Cancer immunity thwarted by the microbiome

25-May-2018 | Nadine Hartmann; Mitchell Kronenberg, Science , 2018

Liver cancer rates have tripled since 1980, making it one of the leading causes of cancer deaths worldwide ( 1 ). The efficacy of a variety of cancer treatments, as well as carcinogenesis itself, can be influenced by the microbiome ( 2 ). Microbiome-cancer interactions are complex, as the ...

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Sustained activation of detoxification pathways promotes liver carcinogenesis in response to chronic bile acid-mediated damage

07-May-2018 | Agnese Collino; Alberto Termanini; Paola Nicoli; Giuseppe Diaferia; Sara Polletti; Camilla Recordati; Vittoria Casti ..., PLoS Genetics, 2018

by Agnese Collino, Alberto Termanini, Paola Nicoli, Giuseppe Diaferia, Sara Polletti, Camilla Recordati, Vittoria Castiglioni, Donatella Caruso, Nico Mitro, Gioacchino Natoli, Serena Ghisletti Chronic inflammation promotes oncogenic transformation and tumor progression. Many inflammatory agents ...

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Relationship of serum immunoglobulin levels to blood pressure and hypertension in an adult population

07-Feb-2018 | Xiaotong Wang; Yajun Li; Huihui Li; Yeqing Gu; Yanqi Song; Qing Zhang; Li Liu; Ge Meng; Zhanxin Yao; Hongmei Wu; Yan ..., Journal of Human Hypertension, 2018

Evidence suggests long-term chronic inflammation, as the pathological basis of formation and development, plays an important part in atherosclerosis. Immunoglobulins (Igs) provided key information on the humoral immune status. However, few studies have evaluated the correlation between Igs and ...

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The immunology of hepatocellular carcinoma

29-Jan-2018 | Marc Ringelhan; Dominik Pfister; Tracy O’Connor; Eli Pikarsky; Mathias Heikenwalder, Nature Immunology, 2018

In contrast to most other malignancies, hepatocellular carcinoma (HCC), which accounts for approximately 90% of primary liver cancers, arises almost exclusively in the setting of chronic inflammation. Irrespective of etiology, a typical sequence of chronic necroinflammation, compensatory liver ...

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Risk of infantile hemangiomas in the offspring of women with autoimmune disease and the pathogenic implications of these lesions

17-Jan-2018 | Chelsey J. F. Smith, Kenneth L. Jones, Diana L. Johnson, Gretchen Bandoli, Loan K. Robinson, Arthur Kavanaugh, Chris ..., American Journal of Medical Genetics Part A, 2018

The purpose of this study was to analyze the risk of maternal autoimmune disease or associated treatments on infantile hemangiomas (IHs), a common benign vascular tumor in infants, and to better understand how maternal chronic inflammation may play a factor in the pathogenesis of these lesions. ...

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Risk of infantile hemangiomas in the offspring of women with autoimmune disease and the pathogenic implications of these lesions

17-Jan-2018 | Chelsey J. F. Smith, Kenneth L. Jones, Diana L. Johnson, Gretchen Bandoli, Loan K. Robinson, Arthur Kavanaugh, Chris ..., American Journal of Medical Genetics Part A, 2018

The purpose of this study was to analyze the risk of maternal autoimmune disease or associated treatments on infantile hemangiomas (IHs), a common benign vascular tumor in infants, and to better understand how maternal chronic inflammation may play a factor in the pathogenesis of these lesions. ...

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