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4,399 Newest Publications about the topic chromatin


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Sex reversal following deletion of a single distal enhancer of Sox9

29-Jun-2018 | Nitzan Gonen; Chris R. Futtner; Sophie Wood; S. Alexandra Garcia-Moreno; Isabella M. Salamone; Shiela C. Samson; Ryo ..., Science , 2018

Cell fate decisions require appropriate regulation of key genes. Sox9, a direct target of SRY, is pivotal in mammalian sex determination. In vivo high-throughput chromatin accessibility techniques, transgenic assays, and genome editing revealed several novel gonadal regulatory elements in the ...


Chromatin remodeling by the NuRD complex regulates development of follicular helper and regulatory T cells [Immunology and Inflammation]

26-Jun-2018 | Erxia Shen; Qin Wang; Hardis Rabe; Wenquan Liu; Harvey Cantor; Jianmei W. Leavenworth, Proceedings of the National Academy of Sciences current issue, 2018

Production of high-affinity antibody responses after infection or vaccination requires precise control of germinal center B cells by follicular helper T cells and follicular regulatory T cells. Although the Bcl6 transcription factor plays a central role in follicular T cell differentiation, the ...


Murine leukemia virus p12 tethers the capsid-containing pre-integration complex to chromatin by binding directly to host nucleosomes in mitosis

15-Jun-2018 | Madushi Wanaguru; David J. Barry; Donald J. Benton; Nicola J. O’Reilly; Kate N. Bishop, PLoS Pathogens, 2018

by Madushi Wanaguru, David J. Barry, Donald J. Benton, Nicola J. O’Reilly, Kate N. Bishop The murine leukaemia virus (MLV) Gag cleavage product, p12, is essential for both early and late steps in viral replication. The N-terminal domain of p12 binds directly to capsid (CA) and stabilises the ...


The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans

07-Jun-2018 | Ye Hong; Maria Velkova; Nicola Silva; Marlène Jagut; Viktor Scheidt; Karim Labib; Verena Jantsch; Anton Gartner, PLoS Genetics, 2018

by Ye Hong, Maria Velkova, Nicola Silva, Marlène Jagut, Viktor Scheidt, Karim Labib, Verena Jantsch, Anton Gartner Homologous recombination is essential for crossover (CO) formation and accurate chromosome segregation during meiosis. It is of considerable importance to work out how ...


Cancer epigenetics: Moving forward

07-Jun-2018 | Angela Nebbioso; Francesco Paolo Tambaro; Carmela Dell’Aversana; Lucia Altucci, PLoS Genetics, 2018

by Angela Nebbioso, Francesco Paolo Tambaro, Carmela Dell’Aversana, Lucia Altucci Defects in chromatin modifiers and remodelers have been described both for hematological and solid malignancies, corroborating and strengthening the role of epigenetic aberrations in the etiology of cancer. ...


Histone depletion prevents telomere fusions in pre-senescent cells

07-Jun-2018 | Marta Barrientos-Moreno; Marina Murillo-Pineda; Ana M. Muñoz-Cabello; Félix Prado, PLoS Genetics, 2018

by Marta Barrientos-Moreno, Marina Murillo-Pineda, Ana M. Muñoz-Cabello, Félix Prado Upon telomerase inactivation, telomeres gradually shorten with each cell division until cells enter replicative senescence. In Saccharomyces cerevisiae, the kinases Mec1/ATR and Tel1/ATM protect the genome ...


Epigenetic switch from repressive to permissive chromatin in response to cold stress [Plant Biology]

05-Jun-2018 | Junghoon Park; Chae Jin Lim; Mingzhe Shen; Hee Jin Park; Joon-Yung Cha; Elisa Iniesto; Vicente Rubio; Tesfaye Mengis ..., Proceedings of the National Academy of Sciences current issue, 2018

Phenotypic adaptations of plants in response to changes in climate are well known to be mediated by molecular mechanisms, including activation or suppression of transcription factors that control target gene expression. However, the chromatin changes that are essential for the binding of ...


RNA editing in nascent RNA affects pre-mRNA splicing [RESEARCH]

01-Jun-2018 | Yun-Hua Esther Hsiao; Jae Hoon Bahn; Yun Yang; Xianzhi Lin; Stephen Tran; Ei-Wen Yang; Giovanni Quinones-Valdez; Xin ..., Genome Research, 2018

In eukaryotes, nascent RNA transcripts undergo an intricate series of RNA processing steps to achieve mRNA maturation. RNA editing and alternative splicing are two major RNA processing steps that can introduce significant modifications to the final gene products. By tackling these processes in ...


Nucleus Assembly and Import in Xenopus laevis Egg Extract

01-Jun-2018 | Chen, P., Levy, D. L., CSH Protocols, 2018

Xenopus egg extract represents a powerful cell-free biochemical tool for studying organelle assembly and function. Large quantities of cytoplasm can be isolated, and biochemical manipulation of extract composition and cell cycle state is relatively straightforward. In this protocol, we describe ...


The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes [RESEARCH]

01-Jun-2018 | Luisa Robbez-Masson; Christopher H.C. Tie; Lucia Conde; Hale Tunbak; Connor Husovsky; Iva A. Tchasovnikarova; Richar ..., Genome Research, 2018

Retrotransposons encompass half of the human genome and contribute to the formation of heterochromatin, which provides nuclear structure and regulates gene expression. Here, we asked if the human silencing hub (HUSH) complex is necessary to silence retrotransposons and whether it collaborates ...


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