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2,280 Newest Publications about the topic chemotherapy

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Hypoxic tumor microenvironment activates GLI2 via HIF-1{alpha} and TGF-{beta}2 to promote chemoresistance in colorectal cancer [Medical Sciences]

26-Jun-2018 | Yen-An Tang; Yu-feng Chen; Yi Bao; Sylvia Mahara; Siti Maryam J. M. Yatim; Gokce Oguz; Puay Leng Lee; Min Feng; Yu C ..., Proceedings of the National Academy of Sciences current issue, 2018

Colorectal cancer patients often relapse due to resistance to chemotherapy. The tumor microenvironment is known to contribute to tumor aggressiveness and chemoresistance, but the underlying mechanisms remain elusive. In the current study, we have shown that cancer-associated fibroblasts (CAFs) ...

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Pharmacokinetics and disposition of miltefosine in healthy mice and hamsters experimentally infected with Leishmania infantum

10-Jun-2018 | Author(s): M. Dolores Jiménez-Antón, Estefanía García-Calvo, Cristina Gutiérrez, Mª.D. Escribano, Nour Kay ..., European Journal of Pharmaceutical Science, 2018

Publication date: 30 August 2018 Source:European Journal of Pharmaceutical Sciences, Volume 121 Author(s): M. Dolores Jiménez-Antón, Estefanía García-Calvo, Cristina Gutiérrez, Mª.D. Escribano, Nour Kayali, José L. Luque-García, Ana Isabel Olías-Molero, María J. Corral, ...

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Adjuvant chemotherapy with S-1 after curative chemoradiotherapy in patients with locoregionally advanced squamous cell carcinoma of the head and neck: Reanalysis of the ACTS-HNC study

08-Jun-2018 | Akira Kubota; Eiji Nakatani; Kiyoaki Tsukahara; Yasuhisa Hasegawa; Hideki Takemura; Tomonori Terada; Takahide Taguch ..., PLoS ONE, 2018

by Akira Kubota, Eiji Nakatani, Kiyoaki Tsukahara, Yasuhisa Hasegawa, Hideki Takemura, Tomonori Terada, Takahide Taguchi, Kunihiko Nagahara, Hiroaki Nakatani, Kunitoshi Yoshino, Yuichiro Higaki, Shigemichi Iwae, Takeshi Beppu, Yutaka Hanamure, Kichinobu Tomita, Naoyuki Kohno, Kazuyoshi Kawabata, ...

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The nutrient environment affects therapy

01-Jun-2018 | Alexander Muir; Matthew G. Vander Heiden, Science , 2018

Understanding the molecular basis of cancer has led to a revolution in how cancers are classified and treated. Subsets of patients benefit from precision-medicine drugs that target growth-promoting signaling networks, but not all cancer patients respond to these approaches ( 1 ). Precision ...

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Qualitative study of patients’ decision-making when accepting second-line treatment after failure of first-line chemotherapy

25-May-2018 | Jean-Louis Pujol; Benoît Roch; Caroline Roth; Jean-Pierre Mérel, PLoS ONE, 2018

by Jean-Louis Pujol, Benoît Roch, Caroline Roth, Jean-Pierre Mérel Objective Treatment failures in advanced lung cancer are frequent events affecting patients during or after first-line chemotherapy. International guidelines recommend second-line chemotherapy. However, around one half of ...

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ICG fluorescence imaging as a new tool for optimization of pathological evaluation in breast cancer tumors after neoadjuvant chemotherapy

25-May-2018 | Isabelle Veys; Catalin-Florin Pop; Romain Barbieux; Michel Moreau; Danielle Noterman; Filip De Neubourg; Jean-Marie ..., PLoS ONE, 2018

by Isabelle Veys, Catalin-Florin Pop, Romain Barbieux, Michel Moreau, Danielle Noterman, Filip De Neubourg, Jean-Marie Nogaret, Gabriel Liberale, Denis Larsimont, Pierre Bourgeois Background Response to neoadjuvant chemotherapy (NACT), particularly pathologic complete response (pCR), is an ...

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MicroRNA21 and the various types of myeloid leukemia

25-May-2018 | Mani Panagal; Senthil Kumar S. R.; Sivakurunathan P.; Biruntha M.; Karthigeyan M.; Vincent Gopinathe; Pethanen Sivak ..., Cancer Gene Therapy, 2018

Myeloid leukemia (ML) is heterogeneous cancer classified by abnormal growth of myeloid cells due to genetic aberrations and mutations. It is generally categorized by clonal disorders of hematopoietic stem cells and differentiation. The molecular mechanism behind the myeloid malignancies is not ...

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Cancer in kidney transplant recipients

25-May-2018 | Eric Au; Germaine Wong; Jeremy R. Chapman, Nature Clinical Practice Nephrology, 2018

Cancer is the second most common cause of mortality and morbidity in kidney transplant recipients after cardiovascular disease. Kidney transplant recipients have at least a twofold higher risk of developing or dying from cancer than the general population. The increased risk of de novo and ...

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Risk of subsequent myeloid neoplasms after radiotherapy treatment for a solid cancer among adults in the United States, 2000–2014

24-May-2018 | Jop C. Teepen; Rochelle E. Curtis; Graça M. Dores; Amy Berrington de Gonzalez; Marry M. van den Heuvel-Eibrink; ..., Leukemia, 2018

Although increased risk of acute myeloid leukemia (AML) has been observed after chemotherapy and radiotherapy, less is known about radiotherapy-related risks of specific AML subtypes and other specific myeloid neoplasms. We used the US population-based cancer registry data to evaluate risk of ...

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Risk of subsequent myeloid neoplasms after radiotherapy treatment for a solid cancer among adults in the United States, 2000–2014

24-May-2018 | Jop C. Teepen; Rochelle E. Curtis; Graça M. Dores; Amy Berrington de Gonzalez; Marry M. van den Heuvel-Eibrink; ..., Leukemia, 2018

Although increased risk of acute myeloid leukemia (AML) has been observed after chemotherapy and radiotherapy, less is known about radiotherapy-related risks of specific AML subtypes and other specific myeloid neoplasms. We used the US population-based cancer registry data to evaluate risk of ...

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