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123 Newest Publications about the topic celecoxib

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Quantification of microwave-induced amorphization of celecoxib in PVP tablets using transmission Raman spectroscopy

15-Apr-2018 | Author(s): Magnus Edinger, Matthias Manne Knopp, Hugo Kerdoncuff, Jukka Rantanen, Thomas Rades, Korbinian ..., European Journal of Pharmaceutical Science, 2018

Publication date: 30 May 2018 Source:European Journal of Pharmaceutical Sciences, Volume 117 Author(s): Magnus Edinger, Matthias Manne Knopp, Hugo Kerdoncuff, Jukka Rantanen, Thomas Rades, Korbinian Löbmann In this study, the influence of drug load on the microwave-induced ...

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Pharmacokinetics of multiple doses of Co‐Crystal of Tramadol‐Celecoxib: findings from a 4‐way randomized open‐label Phase I clinical trial

10-Sep-2017 | Sebastián Videla, Mounia Lahjou, Anna Vaqué, Mariano Sust, Marisol Escriche, Lluis Soler, Artur Sans, Eric Sicard, N ..., British Journal of Clinical Pharmacology, 2017

Summary Aim We compared the pharmacokinetic (PK) profiles of Co‐Crystal of Tramadol‐Celecoxib (CTC) versus each reference product (alone and in open combination) after single (first dose) and multiple dosing. Methods Healthy adults aged 18–50 years received, under fasted conditions, ...

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Dose‐dependent acute liver injury with hypersensitivity features in humans due to a novel microsomal prostaglandin E synthase 1 inhibitor

02-Sep-2017 | Yan Jin, Arie Regev, Jeanelle Kam, Krista Phipps, Claire Smith, Judith Henck, Kristina Campanale, Leijun Hu, D. Greg ..., British Journal of Clinical Pharmacology, 2017

Summary Aim LY3031207, a novel microsomal prostaglandin E synthase 1 inhibitor, was evaluated in a multiple ascending dose study after nonclinical toxicology studies and a single ascending dose study demonstrated an acceptable toxicity, safety, and tolerability ...

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LY3127760, a Selective Prostaglandin E4 (EP4) Receptor Antagonist, and Celecoxib: A Comparison of Pharmacological Profiles

31-Aug-2017 | Yan Jin, Claire Smith, Leijun Hu, David E. Coutant, Kelly Whitehurst, Krista Phipps, Terry Ann McNearney, Xiao Yang, ..., Clinical and Translational Science, 2017

Safety, tolerability, and pharmacology profiles of LY3127760, an EP4 antagonist, were explored in healthy subjects in a subject/investigator‐blind, parallel‐group, multiple‐ascending dose study. Cohorts consisted of 13 patients randomized to LY3127760, celecoxib (400 mg), or placebo (9:2:2 ...

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Celecoxib inhibits osteoblast differentiation independent of cyclooxygenase activity

16-Aug-2017 | Atsushi Matsuyama, Sen Higashi, Saori Tanizaki, Takahiko Morotomi, Ayako Washio, Tomoko Ohsumi, Chiaki Kitamura, Hir ..., Clinical and Experimental Pharmacology and Physiology, 2017

Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) exert their effects primarily by inhibiting the activity of cyclooxygenase (COX), thus suppressing prostaglandin synthesis. Some NSAIDs are known to perform functions other than pain control, such as suppressing tumour cell growth, ...

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Single‐dose pharmacokinetics of Co‐Crystal of Tramadol‐Celecoxib: results of a 4‐way randomized open‐label Phase I clinical trial in healthy subjects

15-Aug-2017 | Sebastián Videla, Mounia Lahjou, Anna Vaqué, Mariano Sust, Mercedes Encabo, Lluis Soler, Artur Sans, Eric Sicard, Ne ..., British Journal of Clinical Pharmacology, 2017

Abstract Aim Co‐Crystal of Tramadol‐Celecoxib (CTC) is a novel co‐crystal molecule containing two active pharmaceutical ingredients (APIs) under development by Esteve (E‐58425) and Mundipharma Research (MR308). This Phase I study compared single‐dose pharmacokinetics (PK) of CTC with those ...

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Single‐dose pharmacokinetics of Co‐Crystal of Tramadol‐Celecoxib: results of a 4‐way randomized open‐label Phase I clinical trial in healthy subjects

15-Aug-2017 | Sebastián Videla, Mounia Lahjou, Anna Vaqué, Mariano Sust, Mercedes Encabo, Lluis Soler, Artur Sans, Eric Sicard, Ne ..., British Journal of Clinical Pharmacology, 2017

Abstract Aim Co‐Crystal of Tramadol‐Celecoxib (CTC) is a novel co‐crystal molecule containing two active pharmaceutical ingredients (APIs) under development by Esteve (E‐58425) and Mundipharma Research (MR308). This Phase I study compared single‐dose pharmacokinetics (PK) of CTC with those ...

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Potential of telmisartan in the treatment of benign prostatic hyperplasia

20-Jul-2017 | Ismail Ogunbayode Ishola, Charles C. Anunobi, Kehinde Habeeb Tijani, Olasunmbo Afolayan, Victoria U. Udokwu, Fundamental & Clinical Pharmacology, 2017

Abstract Benign prostatic hyperplasia (BPH) is a common health problem in aging men. This study was carried out to investigate the protective effect of telmisartan on testosterone induced‐BPH in rats. Fifty‐four male Wistar rats (200 ‐ 250g) were randomly divided into 9 groups (n =6) and ...

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Atorvastatin attenuates testosterone induced benign prostatic hyperplasia in rats: role of peroxisome proliferator activated receptor‐γ and cyclo‐oxygenase‐2

21-Jun-2017 | Ismail O. Ishola, Habeeb K. Tijani, Olufunke O. Dosumu, Charles C. Anunobi, Tolulope O. Oshodi, Fundamental & Clinical Pharmacology, 2017

Abstract Diabetes and obesity have been reported to alter sex steroid hormone metabolism. In this study, an attempt was made to investigate the protective effect of atorvastatin (ATR) in combination with celecoxib (CEL) or pioglitazone (PIO) on testosterone‐induced BPH in rats.Male Wistar ...

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Molecular Factors Governing the Liquid and Glassy States Recrystallization of Celecoxib in Binary Mixtures with Excipients of Different Molecular Weights

08-Mar-2017 | K. Grzybowska; K. Chmiel; J. Knapik-Kowalczuk; A. Grzybowski; K. Jurkiewicz; M. Paluch, Molecular Pharmaceutics, 2017

Transformation of poorly water-soluble crystalline pharmaceuticals to the amorphous form is one of the most promising strategies to improve their oral bioavailability. Unfortunately, the amorphous drugs are usually thermodynamically unstable and may quickly return to their crystalline form. A ...

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