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298 Newest Publications about the topic cancer genes

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Two critical positions in zinc finger domains are heavily mutated in three human cancer types

28-Jun-2018 | Daniel Munro; Dario Ghersi; Mona Singh, PLoS Computational Biology, 2018

by Daniel Munro, Dario Ghersi, Mona Singh A major goal of cancer genomics is to identify somatic mutations that play a role in tumor initiation or progression. Somatic mutations within transcription factors are of particular interest, as gene expression dysregulation is widespread in cancers. ...

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Analysis of triangular motifs in protein interaction networks and their implications to protein ages and cancer genes

28-Apr-2018 | Hyeonseong Jeon; Suh-Ryung Kim; Dougu Nam; Yun Joo Yoo, International Journal of Data Mining and Bioinformatics, 2018

Analysis of triangular motifs in protein interaction networks and their implications to protein ages and cancer genesHyeonseong Jeon; Suh-Ryung Kim; Dougu Nam; Yun Joo YooInternational Journal of Data Mining and Bioinformatics, Vol. 19, No. 4 (2017) pp. 340 - 365Proteins interact with each other ...

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Dissecting the sources of gene expression variation in a pan-cancer analysis identifies novel regulatory mutations

17-Apr-2018 | Sharma A, Jiang C, De S., Nucleic Acids Research, 2018

Abstract Although the catalog of cancer-associated mutations in protein-coding regions is nearly complete for all major cancer types, an assessment of regulatory changes in cancer genomes and their clinical significance remain largely preliminary. Adopting bottom-up approach, we quantify the ...

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Marine Drugs, Vol. 16, Pages 20: Sponges: A Reservoir of Genes Implicated in Human Cancer

10-Jan-2018 | Ćetković, Helena ; Halasz, Mirna ; Herak Bosnar, Maja, Marine Drugs, 2018

Marine Drugs, Vol. 16, Pages 20: Sponges: A Reservoir of Genes Implicated in Human Cancer Marine Drugs doi: 10.3390/md16010020 Authors: Helena Ćetković Mirna Halasz Maja Herak Bosnar Recently, it was shown that the majority of genes linked to human diseases, such as cancer ...

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Semi‐automated cancer genome analysis using high‐performance computing

09-Jun-2017 | Giuliano Crispatzu, Pranav Kulkarni, Mohammad R. Toliat, Peter Nürnberg, Marco Herling, Carmen D. Herling, Peter Fro ..., Human Mutation, 2017

Abstract Next‐Generation Sequencing (NGS) has turned from a new and experimental technology into a standard procedure for cancer genome studies and clinical investigation. While a multitude of software packages for cancer genome data analysis have been made available, these need to be combined ...

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Prediction of Homo sapiens cancer cells by electrical network modelling of amino acid sequence

07-Feb-2017 | Tanusree Roy; Soma Barman, International Journal of Bioinformatics Research and Applications, 2017

Prediction of Homo sapiens cancer cells by electrical network modelling of amino acid sequenceTanusree Roy; Soma BarmanInternational Journal of Bioinformatics Research and Applications, Vol. 13, No. 1 (2017) pp. 75 - 93Amino acids are the essential primary component of every living organism, ...

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Multiscale mutation clustering algorithm identifies pan-cancer mutational clusters associated with pathway-level changes in gene expression

07-Feb-2017 | William Poole; Kalle Leinonen; Ilya Shmulevich; Theo Knijnenburg; Brady Bernard, PLoS Computational Biology, 2017

by William Poole, Kalle Leinonen, Ilya Shmulevich, Theo Knijnenburg, Brady Bernard Cancer researchers have long recognized that somatic mutations are not uniformly distributed within genes. However, most approaches for identifying cancer mutations focus on either the entire-gene or single ...

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Mutated Chromatin Regulatory Factors as Tumor Drivers in Cancer

15-Jan-2017 | Carl Koschmann; Felipe J. Nunez; Flor Mendez; Jacqueline A. Brosnan-Cashman; Alan K. Meeker; Pedro R. Lowenstein; Ma ..., Cancer Research, 2017

Genes encoding proteins that regulate chromatin structure and DNA modifications [i.e., chromatin regulatory factors (CRF)] and genes encoding histone proteins harbor recurrent mutations in most human cancers. These mutations lead to modifications in tumor chromatin and DNA structure and an ...

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Synonymous Somatic Variants in Human Cancer Are Not Infamous: A Plea For Full Disclosure in Databases And Publications

27-Dec-2016 | Thierry Soussi, Peter E.M. Taschner, Yardena Samuels, Human Mutation, 2016

ABSTRACT Single Nucleotide Variants (SNVs) are the most frequent genetic changes found in human cancer. Most driver alterations are missense and nonsense variants localized in the coding region of cancer genes. Unbiased cancer genome sequencing shows that synonymous SNVs (sSNVs) can be found ...

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Genetically engineered mouse models in oncology research and cancer medicine

27-Dec-2016 | Kelly Kersten, Karin E Visser, Martine H Miltenburg, Jos Jonkers, EMBO Molecular Medicine, 2016

Abstract Genetically engineered mouse models (GEMMs) have contributed significantly to the field of cancer research. In contrast to cancer cell inoculation models, GEMMs develop de novo tumors in a natural immune‐proficient microenvironment. Tumors arising in advanced GEMMs closely mimic the ...

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