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392 Newest Publications about the topic bipolar disorder

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Dopamine transporter oligomerization involves the scaffold domain, but spares the bundle domain

06-Jun-2018 | Kumaresan Jayaraman; Alex N. Morley; Daniel Szöllősi; Tjerk A. Wassenaar; Harald H. Sitte; Thomas Stockner, PLoS Computational Biology, 2018

by Kumaresan Jayaraman, Alex N. Morley, Daniel Szöllősi, Tjerk A. Wassenaar, Harald H. Sitte, Thomas Stockner The human dopamine transporter (hDAT) is located on presynaptic neurons, where it plays an essential role in limiting dopaminergic signaling by temporarily curtailing high ...

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Multivariate meta-analyses of mitochondrial complex I and IV in major depressive disorder, bipolar disorder, schizophrenia, Alzheimer disease, and Parkinson disease

16-May-2018 | L Holper; D Ben-Shachar; JJ Mann, Neuropsychopharmacology, 2018

Complex I (NADH dehydrogenase, NDU) and complex IV (cytochrome-c-oxidase, COX) of the mitochondrial electron transport chain have been implicated in the pathophysiology of major psychiatric disorders, such as major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ), as well ...

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Pharmacological treatment of adult bipolar disorder

20-Apr-2018 | Ross J. Baldessarini; Leonardo Tondo; Gustavo H. Vázquez, Molecular Psychiatry, 2018

We summarize evidence supporting contemporary pharmacological treatment of phases of BD, including: mania, depression, and long-term recurrences, emphasizing findings from randomized, controlled trials (RCTs). Effective treatment of acute or dysphoric mania is provided by modern antipsychotics, ...

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Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

09-Apr-2018 | Hilary K. Finucane; Yakir A. Reshef; Verneri Anttila; Kamil Slowikowski; Alexander Gusev; Andrea Byrnes; Steven Gaza ..., Nature Genetics, 2018

We introduce an approach to identify disease-relevant tissues and cell types by analyzing gene expression data together with genome-wide association study (GWAS) summary statistics. Our approach uses stratified linkage disequilibrium (LD) score regression to test whether disease heritability is ...

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Brain lactate and pH in schizophrenia and bipolar disorder: a systematic review of findings from magnetic resonance studies

14-Mar-2018 | Asli Ercan Dogan; Cagri Yuksel; Fei Du; Virginie-Anne Chouinard; Dost Öngür, Neuropsychopharmacology, 2018

Converging evidence from molecular to neuroimaging studies suggests brain energy metabolism abnormalities in both schizophrenia and bipolar disorder. One emerging hypothesis is: decreased oxidative phosphorylation leading to accumulation of lactic acid from glycolysis and subsequent acidification ...

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Mice with reduced DAT levels recreate seasonal-induced switching between states in bipolar disorder

27-Feb-2018 | Jared W. Young; Zackary A. Cope; Benedetto Romoli; Esther Schrurs; Aniek Joosen; Jordy Enkhuizen; Richard F. Sharp; ..., Neuropsychopharmacology, 2018

Developing novel therapeutics for bipolar disorder (BD) has been hampered by limited mechanistic knowledge how sufferers switch between mania and depression—how the same brain can switch between extreme states—described as the “holy grail” of BD research. Strong evidence implicates ...

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3D 7Li magnetic resonance imaging of brain lithium distribution in bipolar disorder

09-Feb-2018 | Fiona Elizabeth Smith; Peter Edward Thelwall; Joe Necus; Carly Jay Flowers; Andrew Matthew Blamire; David Andrew Cousins, Molecular Psychiatry, 2018

Lithium is a major treatment for bipolar disorder and the likelihood of a favourable response may be determined by its distribution in the brain. Lithium can be directly detected by magnetic resonance (MR), but previous 7Li MR spectroscopy studies have demonstrated that this is challenging ...

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Integrating genome‐wide association study summaries and element‐gene interaction datasets identified multiple associations between elements and complex diseases

19-Dec-2017 | Awen He, Wenyu Wang, N. Tejo Prakash, Alexey A. Tinkov, Anatoly V. Skaln, Yan Wen, Jingcan Hao, Xiong Guo, Feng Zhang, Genetic Epidemiology, 2017

ABSTRACT Chemical elements are closely related to human health. Extensive genomic profile data of complex diseases offer us a good opportunity to systemically investigate the relationships between elements and complex diseases/traits. In this study, we applied gene set enrichment analysis ...

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The thalamic reticular nucleus in schizophrenia and bipolar disorder: role of parvalbumin-expressing neuron networks and oxidative stress

28-Nov-2017 | P Steullet; J-H Cabungcal; S A Bukhari; M I Ardelt; H Pantazopoulos; F Hamati; T E Salt; M Cuenod; Kim Q Do; S Berretta, Molecular Psychiatry, 2017

The thalamic reticular nucleus in schizophrenia and bipolar disorder: role of parvalbumin-expressing neuron networks and oxidative stress The thalamic reticular nucleus in schizophrenia and bipolar disorder: role of parvalbumin-expressing neuron networks and oxidative stress, Published online: ...

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Face and predictive validity of the ClockΔ19 mouse as an animal model for bipolar disorder: a systematic review

07-Nov-2017 | M Kristensen; A A Nierenberg; S D Østergaard, Molecular Psychiatry, 2017

Face and predictive validity of the ClockΔ19 mouse as an animal model for bipolar disorder: a systematic review Face and predictive validity of the ClockΔ19 mouse as an animal model for bipolar disorder: a systematic review, Published online: 07 November 2017; doi:10.1038/mp.2017.192

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