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160 Newest Publications about the topic biopharmaceuticals

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Marine Drugs, Vol. 16, Pages 207: The Holo-Transcriptome of the Zoantharian Protopalythoa variabilis (Cnidaria: Anthozoa): A Plentiful Source of Enzymes for Potential Application in Green Chemistry, Industrial and Pharmaceutical Biotechnology

13-Jun-2018 | R. L. Morlighem, Jean-Étienne ; Huang, Chen ; Liao, Qiwen ; Braga Gomes, Paula ; Daniel Pérez, Carlos ; de Brandão P ..., Marine Drugs, 2018

Marine Drugs, Vol. 16, Pages 207: The Holo-Transcriptome of the Zoantharian Protopalythoa variabilis (Cnidaria: Anthozoa): A Plentiful Source of Enzymes for Potential Application in Green Chemistry, Industrial and Pharmaceutical Biotechnology Marine Drugs doi: ...

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Modeling the downstream processing of monoclonal antibodies reveals cost advantages for continuous methods for a broad range of manufacturing scales

17-Jan-2018 | Jonathan Hummel, Mark Pagkaliwangan, Xhorxhi Gjoka, Terence Davidovits, Rick Stock, Thomas Ransohoff, Rene Gantier, ..., Biotechnology Journal, 2018

The biopharmaceutical industry is evolving in response to changing market conditions, including increasing competition and growing pressures to reduce costs. Single‐use technologies and continuous bioprocessing have attracted attention as potential facilitators of cost‐optimized manufacturing ...

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Changes in chromosome counts and patterns in CHO cell lines upon generation of recombinant cell lines and subcloning

12-Jan-2018 | Sabine Vcelar, Michael Melcher, Norbert Auer, Astrid Hrdina, Anja Puklowski, Friedrich Leisch, Vaibhav Jadhav, Till ..., Biotechnology Journal, 2018

Chinese hamster ovary cells are the number one production system for therapeutic proteins. A pre‐requirement for their use in industrial production of biopharmaceuticals is to be clonal, thus originating from a single cell in order to be phenotypically and genomically identical. In the present ...

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HPV‐16 targeted DNA vaccine expression: The role of purification

05-Jan-2018 | Ana M. Almeida, Joana Tomás, Patrícia Pereira, João A. Queiroz, Fani Sousa, Ângela Sousa, Biotechnology Progress, 2018

Abstract DNA vaccines have come to light in the last decades as an alternative method to prevent many infectious diseases, but they can also be used for the treatment of specific diseases, such as cervical cancer caused by Human Papillomavirus (HPV). This virus produces E6 and E7 oncoproteins, ...

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Identification of process conditions influencing protein aggregation in Chinese hamster ovary cell culture

27-Dec-2017 | Albert Jesuran Paul, René Handrick, Sybille Ebert, Friedemann Hesse, Biotechnology and Bioengineering, 2017

Abstract Protein aggregation of monoclonal antibodies (mAbs) is a common phenomenon associated with the production of these biopharmaceuticals. These aggregates can lead to adverse side effects in patients upon administration, thus expensive downstream processing steps to remove the higher ...

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Resveratrol and inflammatory bowel disease

25-Sep-2017 | Yaning Shi, Jie Zhou, Bo Jiang, Ming Miao, Annals of the New York Academy of Sciences, 2017

Abstract Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract, comprising ulcerative colitis (UC) and Crohn's disease (CD). Progression of IBD leads to long‐term impairment of intestinal structure and function. The pathogenesis of IBD is complex, ...

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Resveratrol and inflammatory bowel disease

25-Sep-2017 | Yaning Shi, Jie Zhou, Bo Jiang, Ming Miao, Annals of the New York Academy of Sciences, 2017

Abstract Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract, comprising ulcerative colitis (UC) and Crohn's disease (CD). Progression of IBD leads to long‐term impairment of intestinal structure and function. The pathogenesis of IBD is complex, ...

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Tuning and Predicting Mesh Size and Protein Release from Step Growth Hydrogels

14-Sep-2017 | Matthew S. Rehmann; Kelsi M. Skeens; Prathamesh M. Kharkar; Eden M. Ford; Emanual Maverakis; Kelvin H. Lee; April M. ..., Biomacromolecules, 2017

Hydrogel-based depots are of growing interest for release of biopharmaceuticals; however, a priori selection of hydrogel compositions that will retain proteins of interest and provide desired release profiles remains elusive. Toward addressing this, in this work, we have established a new tool ...

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Repurposing ribosomes for synthetic biology

03-Sep-2017 | Author(s): Yi Liu, Do Soon Kim, Michael C Jewett, Current Opinion in Chemical Biology, 2017

Publication date: October 2017 Source:Current Opinion in Chemical Biology, Volume 40 Author(s): Yi Liu, Do Soon Kim, Michael C Jewett The translation system is the cell's factory for protein biosynthesis, stitching together hundreds to thousands of amino acids into proteins, which are ...

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Development of a general defined medium for Pichia pastoris

02-Sep-2017 | Catherine Bartlett Matthews, Angel Kuo, Kerry Routenberg Love, J. Christopher Love, Biotechnology and Bioengineering, 2017

Abstract Pichia pastoris is widely used as a host for recombinant protein production. More than 500 proteins have been expressed in the organism at a variety of cultivation scales, from small shake flasks to large bioreactors. Large‐scale fermentation strategies typically employ ...

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