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10,928 Newest Publications about the topic bacteria

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Viruses, Vol. 10, Pages 351: Resistance Development to Bacteriophages Occurring during Bacteriophage Therapy

30-Jun-2018 | Oechslin, Frank, Viruses, 2018

Viruses, Vol. 10, Pages 351: Resistance Development to Bacteriophages Occurring during Bacteriophage Therapy Viruses doi: 10.3390/v10070351 Authors: Frank Oechslin Bacteriophage (phage) therapy, i.e., the use of viruses that infect bacteria as antimicrobial agents, is a promising ...

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Marine Drugs, Vol. 16, Pages 221: Seaweed Extract (Stella Maris®) Activates Innate Immune Responses in Arabidopsis thaliana and Protects Host against Bacterial Pathogens

28-Jun-2018 | Cook, Jamie ; Zhang, Janie ; Norrie, Jeff ; Blal, Bachar ; Cheng, Zhenyu, Marine Drugs, 2018

Marine Drugs, Vol. 16, Pages 221: Seaweed Extract (Stella Maris®) Activates Innate Immune Responses in Arabidopsis thaliana and Protects Host against Bacterial Pathogens Marine Drugs doi: 10.3390/md16070221 Authors: Jamie Cook Janie Zhang Jeff Norrie Bachar Blal Zhenyu ...

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Direct activation of a phospholipase by cyclic GMP-AMP in El Tor Vibrio cholerae [Microbiology]

26-Jun-2018 | Geoffrey B. Severin; Miriam S. Ramliden; Lisa A. Hawver; Kun Wang; Macy E. Pell; Ann-Katrin Kieninger; Atul Khataoka ..., Proceedings of the National Academy of Sciences current issue, 2018

Second messengers are employed by all organisms to regulate fundamental behaviors, including biofilm formation, motility, metabolism, and pathogenesis in bacteria. We have identified a phospholipase in the El Tor Vibrio cholerae biotype, responsible for the current cholera pandemic, that is ...

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Lipid binding attenuates channel closure of the outer membrane protein OmpF [Biochemistry]

26-Jun-2018 | Idlir Liko; Matteo T. Degiacomi; Sejeong Lee; Thomas D. Newport; Joseph Gault; Eamonn Reading; Jonathan T. S. Hopper ..., Proceedings of the National Academy of Sciences current issue, 2018

Outer-membrane porins are often considered as passive conduits of small molecules across lipid bilayers. Using native mass spectrometry experiments we identify a pH-sensitive lipid-binding mechanism of outer membrane porin F, which enables increased threading of a colicin-derived peptide through ...

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Going on offense against the gram-negative defense [Microbiology]

26-Jun-2018 | Bryon S. Drown; Paul J. Hergenrother, Proceedings of the National Academy of Sciences current issue, 2018

Bacterial infections resistant to antibiotics are becoming more common, posing a significant health risk (1). The CDC and WHO have identified gram-negative drug-resistant pathogens as being particularly dangerous, and such infections are resistant to nearly all available antibiotics in some cases ...

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Bacterial iron acquisition mediated by outer membrane translocation and cleavage of a host protein [Microbiology]

26-Jun-2018 | Khedidja Mosbahi; Marta Wojnowska; Amaya Albalat; Daniel Walker, Proceedings of the National Academy of Sciences current issue, 2018

The outer membrane of Gram-negative bacteria is a highly impermeable barrier to a range of toxic chemicals and is responsible for the resistance of these bacteria to important classes of antibiotics. In this work, we show that plant pathogenic Pectobacterium spp. acquire iron from the small, ...

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Staphylococcus aureus targets the purine salvage pathway to kill phagocytes [Microbiology]

26-Jun-2018 | Volker Winstel; Dominique Missiakas; Olaf Schneewind, Proceedings of the National Academy of Sciences current issue, 2018

Immune evasion by the human pathogen Staphylococcus aureus includes the synthesis of cytotoxic deoxyadenosine (dAdo) from neutrophil extracellular traps to eliminate macrophages. The signaling pathway that triggers dAdo-mediated apoptosis in macrophages is not known. By using a genome-wide ...

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Cell-based screen for discovering lipopolysaccharide biogenesis inhibitors [Microbiology]

26-Jun-2018 | Ge Zhang; Vadim Baidin; Karanbir S. Pahil; Eileen Moison; David Tomasek; Nitya S. Ramadoss; Arnab K. Chatterjee; Cas ..., Proceedings of the National Academy of Sciences current issue, 2018

The outer membrane of gram-negative bacteria contains LPS on the cell surface. The presence of LPS creates an effective permeability barrier that protects gram-negative bacteria from small hydrophobic molecules. Because the entire LPS biogenesis pathway, including biosynthesis and transport, is ...

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Structure and mutagenic analysis of the lipid II flippase MurJ from Escherichia coli [Biophysics and Computational Biology]

26-Jun-2018 | Sanduo Zheng; Lok-To Sham; Frederick A. Rubino; Kelly P. Brock; William P. Robins; John J. Mekalanos; Debora S. Mark ..., Proceedings of the National Academy of Sciences current issue, 2018

A peptidoglycan cell wall provides bacteria with protection from environmental stresses, and interfering with assembly of the cell wall is among the most effective strategies for antibiotic development. To build a cell wall, bacteria first synthesize lipid II on the inner leaflet of their ...

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The impact of temporal sampling resolution on parameter inference for biological transport models

25-Jun-2018 | Jonathan U. Harrison; Ruth E. Baker, PLoS Computational Biology, 2018

by Jonathan U. Harrison, Ruth E. Baker Imaging data has become an essential tool to explore key biological questions at various scales, for example the motile behaviour of bacteria or the transport of mRNA, and it has the potential to transform our understanding of important transport ...

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