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1,720 Newest Publications about the topic antigens


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A site for sore eyes

29-Jun-2018 | Caroline Ash; Jesse Smith; Seth Thomas Scanlon, Science , 2018

Immunology![Figure][1] Damage to one eye causes harmful responses in the uninjured eye. PHOTO: JENA ARDELL Mucosal tolerance arises when exposure to foreign antigens at mucosal sites results in suppressed immune responses mediated by regulatory T cells and tolerogenic antigen-presenting


Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope

22-Jun-2018 | Katharina Imkeller; Stephen W. Scally; Alexandre Bosch; Gemma Pidelaserra Martí; Giulia Costa; Gianna Triller; Rajag ..., Science , 2018

Affinity maturation selects B cells expressing somatically mutated antibody variants with improved antigen-binding properties to protect from invading pathogens. We determined the molecular mechanism underlying the clonal selection and affinity maturation of human B cells expressing protective ...


Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria

08-Jun-2018 | Frederica D. Partey; Filip C. Castberg; Edem W. Sarbah; Sarah E. Silk; Gordon A. Awandare; Simon J. Draper; Nicholas ..., PLoS ONE, 2018

by Frederica D. Partey, Filip C. Castberg, Edem W. Sarbah, Sarah E. Silk, Gordon A. Awandare, Simon J. Draper, Nicholas Opoku, Margaret Kweku, Michael F. Ofori, Lars Hviid, Lea Barfod Plasmodium falciparum PfRH5 protein binds Ripr, CyRPA and Pf113 to form a complex that is essential for ...


[Immunology] Which Dengue Vaccine Approach Is the Most Promising, and Should We Be Concerned about Enhanced Disease after Vaccination?: There Is Only One True Winner

01-Jun-2018 | Scott B. Halstead, CSH Perspectives, 2018

The scientific community now possesses information obtained directly from human beings that makes it possible to understand why breakthrough-enhanced dengue virus (DENV) infections occurred in children receiving Sanofi Pasteur’s Dengvaxia tetravalent live attenuated vaccine and to predict the ...


Viruses, Vol. 10, Pages 298: Baculovirus Surface Display of Immunogenic Proteins for Vaccine Development

31-May-2018 | Premanand, Balraj ; Zhong Wee, Poh ; Prabakaran, Mookkan, Viruses, 2018

Viruses, Vol. 10, Pages 298: Baculovirus Surface Display of Immunogenic Proteins for Vaccine Development Viruses doi: 10.3390/v10060298 Authors: Balraj Premanand Poh Zhong Wee Mookkan Prabakaran Vaccination is an efficient way to prevent the occurrence of many infectious ...


Regulatory mechanisms in T cell receptor signalling

22-May-2018 | Guillaume Gaud; Renaud Lesourne; Paul E. Love, Nature Reviews Immunology, 2018

The remarkable T cell receptor (TCR) performs essential functions in the initiation of intracellular signals required for T cell development, repertoire selection and effector responses to foreign antigens. How TCR signals elicit such diverse cellular responses and outcomes remains a major ...


Mycobacterium tuberculosis-specific CD4+ and CD8+ T cells differ in their capacity to recognize infected macrophages

21-May-2018 | Jason D. Yang; Daniel Mott; Rujapak Sutiwisesak; Yu-Jung Lu; Fiona Raso; Britni Stowell; Greg Hunter Babunovic; Jinh ..., PLoS Pathogens, 2018

by Jason D. Yang, Daniel Mott, Rujapak Sutiwisesak, Yu-Jung Lu, Fiona Raso, Britni Stowell, Greg Hunter Babunovic, Jinhee Lee, Steve M. Carpenter, Sing Sing Way, Sarah M. Fortune, Samuel M. Behar Containment of Mycobacterium tuberculosis (Mtb) infection requires T cell recognition of infected ...


In situ quantitative bioanalysis of monomethyl auristatin E-conjugated antibody-drug conjugates by flow cytometry

20-May-2018 | Author(s): Wen-Bin Zhao, Chi-Xiao Qiu, Ying Shen, Wen-Hui Liu, Jie Zhou, Ying-Chun Xu, Zhan Zhou, Shu- ..., European Journal of Pharmaceutical Science, 2018

Publication date: 30 July 2018 Source:European Journal of Pharmaceutical Sciences, Volume 120 Author(s): Wen-Bin Zhao, Chi-Xiao Qiu, Ying Shen, Wen-Hui Liu, Jie Zhou, Ying-Chun Xu, Zhan Zhou, Shu-Qing Chen Antibody-drug conjugates (ADCs) consist of cytotoxic agents ...


Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig

17-May-2018 | Katie Tungatt; Garry Dolton; Sophie B. Morgan; Meriem Attaf; Anna Fuller; Thomas Whalley; Johanneke D. Hemmink; Emil ..., PLoS Pathogens, 2018

by Katie Tungatt, Garry Dolton, Sophie B. Morgan, Meriem Attaf, Anna Fuller, Thomas Whalley, Johanneke D. Hemmink, Emily Porter, Barbara Szomolay, Maria Montoya, John A. Hammond, John J. Miles, David K. Cole, Alain Townsend, Mick Bailey, Pierre J. Rizkallah, Bryan Charleston, Elma Tchilian, ...


Revealing the specificity of regulatory T cells in murine autoimmune diabetes [Immunology and Inflammation]

15-May-2018 | Allyson Spence; Whitney Purtha; Janice Tam; Shen Dong; Youmin Kim; Chia-Hsin Ju; Teague Sterling; Maki Nakayama; Wil ..., Proceedings of the National Academy of Sciences current issue, 2018

Tissue antigen-specific Tregs are critical for the prevention of organ-specific autoimmune diseases, yet very little is known about their specificity in a natural repertoire. Here, we show an accumulation of antigen-experienced Tregs in the inflamed islets using a mouse model of autoimmune ...


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