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1,506 Newest Publications about the topic alzheimer's disease


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On the role of sidechain size and charge in the aggregation of A{beta}42 with familial mutations [Biophysics and Computational Biology]

26-Jun-2018 | Xiaoting Yang; Georg Meisl; Birgitta Frohm; Eva Thulin; Tuomas P. J. Knowles; Sara Linse, Proceedings of the National Academy of Sciences current issue, 2018

The aggregation of the amyloid-β (Aβ) peptide into amyloid fibrils is associated with Alzheimer’s disease, and several point mutations leading to early-onset disease have been identified in Aβ. By studying the aggregation of five disease-related mutations in vitro, we rationalize their link to ...


Lipidated apolipoprotein E4 structure and its receptor binding mechanism determined by a combined cross-linking coupled to mass spectrometry and molecular dynamics approach

22-Jun-2018 | Nicolas Henry; Eva-Maria Krammer; Florian Stengel; Quentin Adams; François Van Liefferinge; Ellen Hubin; Rui Chaves; ..., PLoS Computational Biology, 2018

by Nicolas Henry, Eva-Maria Krammer, Florian Stengel, Quentin Adams, François Van Liefferinge, Ellen Hubin, Rui Chaves, Rouslan Efremov, Ruedi Aebersold, Guy Vandenbussche, Martine Prévost, Vincent Raussens, Stéphanie Deroo Apolipoprotein E (apoE) is a forefront actor in the transport of lipids ...


Near-atomic model of microtubule-tau interactions

15-Jun-2018 | Elizabeth H. Kellogg; Nisreen M. A. Hejab; Simon Poepsel; Kenneth H. Downing; Frank DiMaio; Eva Nogales, Science , 2018

Tau is a developmentally regulated axonal protein that stabilizes and bundles microtubules (MTs). Its hyperphosphorylation is thought to cause detachment from MTs and subsequent aggregation into fibrils implicated in Alzheimer’s disease. It is unclear which tau residues are crucial for tau-MT ...


Local apoptotic-like mechanisms underlie complement-mediated synaptic pruning [Neuroscience]

12-Jun-2018 | Balázs A. Györffy; Judit Kun; György Török; Éva Bulyáki; Zsolt Borhegyi; Péter Gulyássy; Viktor Kis; Péter Szocsics; ..., Proceedings of the National Academy of Sciences current issue, 2018

Synaptic pruning is dominant in early ontogenesis when a large number of unnecessary synapses are eliminated, and it maintains synaptic plasticity in the mature healthy brain, e.g., in memory processes. Its malfunction is involved in degenerative diseases such as Alzheimer’s disease. C1q, a ...


Protein kinase C{alpha} gain-of-function variant in Alzheimer’s disease displays enhanced catalysis by a mechanism that evades down-regulation [Biochemistry]

12-Jun-2018 | Julia A. Callender; Yimin Yang; Gema Lordén; Natalie L. Stephenson; Alexander C. Jones; John Brognard; Alexandra C. ..., Proceedings of the National Academy of Sciences current issue, 2018

This work unveils how an Alzheimer’s disease-associated mutation (M489V) in protein kinase Cα (PKCα) enhances catalytic activity without sensitizing the protein to the cell’s homeostatic degradation of aberrantly active PKCα. The active conformation of wild-type PKC is sensitive to degradation, ...


Oral administration of Pantoea agglomerans-derived lipopolysaccharide prevents metabolic dysfunction and Alzheimer’s disease-related memory loss in senescence-accelerated prone 8 (SAMP8) mice fed a high-fat diet

01-Jun-2018 | Yutaro Kobayashi; Hiroyuki Inagawa; Chie Kohchi; Kimiko Kazumura; Hiroshi Tsuchiya; Toshiyuki Miwa; Katsuichiro Okaz ..., PLoS ONE, 2018

by Yutaro Kobayashi, Hiroyuki Inagawa, Chie Kohchi, Kimiko Kazumura, Hiroshi Tsuchiya, Toshiyuki Miwa, Katsuichiro Okazaki, Gen-Ichiro Soma The pathogenesis of Alzheimer’s disease (AD) remains unclear, but an imbalance between the production and clearance of amyloid-β (Aβ) peptides is known to ...


A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease

25-May-2018 | Sara Mostafavi; Chris Gaiteri; Sarah E. Sullivan; Charles C. White; Shinya Tasaki; Jishu Xu; Mariko Taga; Hans-Ulric ..., Nature Neuroscience, 2018

There is a need for new therapeutic targets with which to prevent Alzheimer’s disease (AD), a major contributor to aging-related cognitive decline. Here we report the construction and validation of a molecular network of the aging human frontal cortex. Using RNA sequence data from 478 ...


Design of optimal nonlinear network controllers for Alzheimer's disease

24-May-2018 | Lazaro M. Sanchez-Rodriguez; Yasser Iturria-Medina; Erica A. Baines; Sabela C. Mallo; Mehdy Dousty; Roberto C. Soter ..., PLoS Computational Biology, 2018

by Lazaro M. Sanchez-Rodriguez, Yasser Iturria-Medina, Erica A. Baines, Sabela C. Mallo, Mehdy Dousty, Roberto C. Sotero, on behalf of The Alzheimer’s Disease Neuroimaging Initiative Brain stimulation can modulate the activity of neural circuits impaired by Alzheimer’s disease (AD), having ...


Computational insights into β-site amyloid precursor protein enzyme 1 (BACE1) inhibition by tanshinones and salvianolic acids from Salvia miltiorrhiza via molecular docking simulations

20-May-2018 | Author(s): Ting Yu, Pradeep Paudel, Su Hui Seong, Jeong Ah Kim, Hyun Ah Jung, Jae Sue Choi, Computational Biology and Chemistry, 2018

Publication date: Available online 13 April 2018 Source:Computational Biology and Chemistry Author(s): Ting Yu, Pradeep Paudel, Su Hui Seong, Jeong Ah Kim, Hyun Ah Jung, Jae Sue Choi The rhizome of Salvia miltiorrhiza has emerged as a rich source of natural therapeutic agents, ...


Combined QSAR, molecular docking and molecular dynamics study on new Acetylcholinesterase and Butyrylcholinesterase inhibitors

20-May-2018 | Author(s): Ismail Daoud, Nadjib Melkemi, Toufik Salah, Said Ghalem, Computational Biology and Chemistry, 2018

Publication date: June 2018 Source:Computational Biology and Chemistry, Volume 74 Author(s): Ismail Daoud, Nadjib Melkemi, Toufik Salah, Said Ghalem Background and purpose This work deals with several molecular modeling methods used to discover new therapeutic agents for treating ...


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