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668 Newest Publications about the topic addiction

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Development and testing of AAV-delivered single-chain variable fragments for the treatment of methamphetamine abuse

29-Jun-2018 | Charles E. Hay; Guillermo A. Gonzalez III; Laura E. Ewing; E. Elizabeth Reichard; Michael D. Hambuchen; Nisha Nanawa ..., PLoS ONE, 2018

by Charles E. Hay, Guillermo A. Gonzalez III, Laura E. Ewing, E. Elizabeth Reichard, Michael D. Hambuchen, Nisha Nanaware-Kharade, Sinthia Alam, Chris T. Bolden, S. Michael Owens, Paris Margaritis, Eric C. Peterson Methamphetamine (METH) substance abuse disorders have major impact on society, ...

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Dialing down the opioids

22-Jun-2018 | Caroline Ash; Leslie K. Ferrarelli, Science , 2018

Pain The pain relief afforded by morphine and other opioids comes with the cost of behavioral side effects and high addiction potential. He et al. found that the analgesic response to morphine could be enhanced by compounds that activate the peripheral sensory neuron–localized receptor MrgC11 in

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Does human language limit translatability of clinical and preclinical addiction research?

17-May-2018 | Harriet Wit; David H. Epstein; Kenzie L. Preston, Neuropsychopharmacology, 2018

Does human language limit translatability of clinical and preclinical addiction research? Does human language limit translatability of clinical and preclinical addiction research?, Published online: 17 May 2018; doi:10.1038/s41386-018-0095-8 Does human language limit translatability of clinical ...

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Exploring parent expectations of neonatal therapeutic hypothermia

08-May-2018 | Alexa K. Craig; Roslyn Gerwin; Janelle Bainter; Scott Evans; Christine James, Journal of Perinatology, 2018

We aimed to assess the parent experience of therapeutic hypothermia (TH), specifically focusing on unmet expectations. Open-ended questions were used in a focus group setting. We employed an inductive approach to develop thematic content from the transcribed recordings. 30 parents of infants ...

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NAD+ cellular redox and SIRT1 regulate the diurnal rhythms of tyrosine hydroxylase and conditioned cocaine reward

04-May-2018 | Ryan W. Logan; Puja K. Parekh; Gabrielle N. Kaplan; Darius D. Becker-Krail; Wilbur P. Williams; Shintaro Yamaguchi; ..., Molecular Psychiatry, 2018

The diurnal regulation of dopamine is important for normal physiology and diseases such as addiction. Here we find a novel role for the CLOCK protein to antagonize CREB-mediated transcriptional activity at the tyrosine hydroxylase (TH) promoter, which is mediated by the interaction with the ...

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Hypertonicity-enforced BCL-2 addiction unleashes the cytotoxic potential of death receptors

30-Apr-2018 | Simon Sirtl; Gertrud Knoll; Dieu Thuy Trinh; Isabell Lang; Daniela Siegmund; Stefanie Gross; Beatrice Schuler-Thurne ..., Oncogene, 2018

Attempts to exploit the cytotoxic activity of death receptors (DR) for treating cancer have thus far been disappointing. DR activation in most malignant cells fails to trigger cell death and may even promote tumor growth by activating cell death-independent DR-associated signaling pathways. ...

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Hypertonicity-enforced BCL-2 addiction unleashes the cytotoxic potential of death receptors

30-Apr-2018 | Simon Sirtl; Gertrud Knoll; Dieu Thuy Trinh; Isabell Lang; Daniela Siegmund; Stefanie Gross; Beatrice Schuler-Thurne ..., Oncogene, 2018

Attempts to exploit the cytotoxic activity of death receptors (DR) for treating cancer have thus far been disappointing. DR activation in most malignant cells fails to trigger cell death and may even promote tumor growth by activating cell death-independent DR-associated signaling pathways. ...

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Known and novel roles of the MET oncogene in cancer: a coherent approach to targeted therapy

19-Apr-2018 | Paolo M. Comoglio; Livio Trusolino; Carla Boccaccio, Nature Reviews Cancer, 2018

The MET oncogene encodes an unconventional receptor tyrosine kinase with pleiotropic functions: it initiates and sustains neoplastic transformation when genetically altered (‘oncogene addiction’) and fosters cancer cell survival and tumour dissemination when transcriptionally activated in the ...

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Behavioral and neurobiological mechanisms of punishment: implications for psychiatric disorders

27-Mar-2018 | Philip Jean-Richard-Dit-Bressel; Simon Killcross; Gavan P. McNally, Neuropsychopharmacology, 2018

Punishment involves learning about the relationship between behavior and its adverse consequences. Punishment is fundamental to reinforcement learning, decision-making and choice, and is disrupted in psychiatric disorders such as addiction, depression, and psychopathy. However, little is known ...

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The multiple paths towards MET receptor addiction in cancer

19-Mar-2018 | Leslie Duplaquet; Zoulika Kherrouche; Simon Baldacci; Philippe Jamme; Alexis B. Cortot; Marie-Christine Copin; David ..., Oncogene, 2018

Targeted therapies against receptor tyrosine kinases (RTKs) are currently used with success on a small proportion of patients displaying clear oncogene activation. Lung cancers with a mutated EGFR provide a good illustration. The efficacy of targeted treatments relies on oncogene addiction, a ...

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