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13,733 Newest Publications of American Chemical Society Publications
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19-Jan-2018 | Yiwen Zhou; Fei Yu; Feiran Zhang; Gang Chen; Kaikai Wang; Minjie Sun; Jing Li; David Oupický, Biomacromolecules, 2018
Chemokine receptor CXCR4 plays an important role in cancer cell invasion and metastasis. Recent findings suggest that anti-VEGF therapies upregulate CXCR4 expression, which contributes to resistance to antiangiogenic therapies. Here, we report the development of novel derivatives of ...
19-Jan-2018 | Yulin Ren; Judith C. Gallucci; Xinxin Li; Lichao Chen; Jianhua Yu; A. Douglas Kinghorn, Journal of Natural Products, 2018
The molecular structures of three parthenolide analogues, (−)-goyazensolide (1), (−)-15-deoxygoyazensolide (2), and (−)-ereglomerulide (3), isolated from the leaves of Piptocoma rufescens in a previous study were determined by X-ray analysis, and the absolute configuration of (−)-goyazensolide ...
19-Jan-2018 | Christian Luebbert; Maximilian Wessner; Gabriele Sadowski, Molecular Pharmaceutics, 2018
The molecular integration of poorly water soluble active pharmaceutical ingredients (APIs) in a suitable polymeric matrix is a possible approach to enhance the dissolution behavior and solubility of these APIs. Like all newly developed pharmaceutical formulations, these formulations (often ...
19-Jan-2018 | Fei Liu; Teli Liu; Xiaoxia Xu; Xiaoyi Guo; Nan Li; Chiyi Xiong; Chun Li; Hua Zhu; Zhi Yang, Molecular Pharmaceutics, 2018
Most of the radiolabeled somatostatin analogues (SSAs) are specific for subtype somatostatin receptor 2 (SSTR2). Lack of ligands targeting other subtypes of SSTRs, especially SSTR1, SSTR3, and SSTR5, limited their applications in tumors of low SSTR2 expression, including lung tumor. In this ...
18-Jan-2018 | Manoj Kushwaha; Shreyans K. Jain; Nisha Sharma; Vidushi Abrol; Sundeep Jaglan; Ram A. Vishwakarma, ACS Chemical Biology, 2018
Targeting the main three networking systems, viz. Las, RhI, and PQS, via natural quenchers is a new ray of hope for combating the persistent behavior of Pseudomonas aeruginosa. In the bacterial chemical vocabulary pyocyanin, N-AHLs and rhamnolipids are the main keywords, which are responsible for ...
18-Jan-2018 | Md. D. Hossain; James C. Reid; Derong Lu; Zhongfan Jia; Debra J. Searles; Michael J. Monteiro, Biomacromolecules, 2018
Cyclic polymers with internal constraints provide new insight into polymer properties in solution and bulk and can serve as a model system to explain the stability and mobility of cyclic biomacromolecules. The model system used in this work consisted of cyclic polystyrene structures, all with a ...
18-Jan-2018 | Maurizio Bruschi; Andrea Petretto; Federico Caicci; Martina Bartolucci; Daniela Calzia; Laura Santucci; Lucia Manni; ..., Journal of Proteome Research, 2018
The retinal rod outer segment (OS) is a stack of disks surrounded by the plasma membrane, housing proteins related to phototransduction, as well as mitochondrial proteins involved in oxidative phosphorylation (OxPhos). This prompted us to compare the proteome of bovine OS disks and mitochondria ...
18-Jan-2018 | Antje Ziller; Sara S. Nogueira; Eva Hühn; Sergio S. Funari; Gerald Brezesinski; Hermann Hartmann; Ugur Sahin; Heinri ..., Molecular Pharmaceutics, 2018
Insertion of high molecular weight messenger RNA (mRNA) into lyotropic lipid phases as model systems for controlled release formulations for the mRNA was investigated. Low fractions of 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) were used as an anchor to load the mRNA into a lamellar lipid ...
18-Jan-2018 | Hui Guo; Mickaël de Magalhaes Goncalves; Guylaine Ducouret; Dominique Hourdet, Biomacromolecules, 2018
Recently, alginates (ALG) characterized by high mannuronic content (M blocks) have been shown to undergo a reversible sol/gel transition during cooling in the presence of potassium salts. Cold gelling takes place at low temperatures, just below 0 °C for a KCl concentration of 0.3 mol/kg, but the ...
18-Jan-2018 | Sudipta Senapati; Rashmi Shukla; Yamini Bhusan Tripathi; Arun Kumar Mahanta; Dipak Rana; Pralay Maiti, Molecular Pharmaceutics, 2018
Two major problems in chemotherapy, poor bioavailability of hydrophobic anticancer drug and its adverse side effects causing nausea, are taken into account by developing a sustained drug release vehicle along with enhanced bioavailability using two-dimensional layered double hydroxides (LDHs) ...