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467 Newest Publications in nature clinical practice rheumatology

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IL-27 links lipids to autoimmunity

25-May-2018 | Nicholas J. Bernard, Nature Clinical Practice Rheumatology, 2018

IL-27 links lipids to autoimmunity IL-27 links lipids to autoimmunity, Published online: 25 May 2018; doi:10.1038/s41584-018-0026-4 IL-27 links lipids to autoimmunity

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AhR controls tolerance to cell debris

23-May-2018 | Joanna Collison, Nature Clinical Practice Rheumatology, 2018

AhR controls tolerance to cell debris AhR controls tolerance to cell debris, Published online: 23 May 2018; doi:10.1038/s41584-018-0024-6 AhR controls tolerance to cell debris

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Existing and novel biomarkers for precision medicine in systemic sclerosis

22-May-2018 | Peter J. Wermuth; Sonsoles Piera-Velazquez; Joel Rosenbloom; Sergio A. Jimenez, Nature Clinical Practice Rheumatology, 2018

The discovery and validation of biomarkers resulting from technological advances in the analysis of genomic, transcriptomic, lipidomic and metabolomic pathways involved in the pathogenesis of complex human diseases have led to the development of personalized and rationally designed approaches for ...

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Neurobiological similarities between RA and fibromyalgia

15-May-2018 | Fabiola Atzeni; Piercarlo Sarzi-Puttini, Nature Clinical Practice Rheumatology, 2018

Neurobiological similarities between RA and fibromyalgia Neurobiological similarities between RA and fibromyalgia, Published online: 15 May 2018; doi:10.1038/s41584-018-0011-y Pain management can be a difficult problem for patients with rheumatoid arthritis (RA), some of whom can experience pain ...

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Fyn-ding a target for OA therapy

14-May-2018 | Nicholas J. Bernard, Nature Clinical Practice Rheumatology, 2018

Fyn-ding a target for OA therapy Fyn-ding a target for OA therapy, Published online: 14 May 2018; doi:10.1038/s41584-018-0020-x Fyn-ding a target for OA therapy

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Biomarkers as drug development tools: discovery, validation, qualification and use

14-May-2018 | Virginia B. Kraus, Nature Clinical Practice Rheumatology, 2018

The 21st Century Cures Act, approved in the USA in December 2016, has encouraged the establishment of the national Precision Medicine Initiative and the augmentation of efforts to address disease prevention, diagnosis and treatment on the basis of a molecular understanding of disease. The Act ...

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Multimerized IgG1 Fc molecule as an anti-inflammatory agent

14-May-2018 | Emmanuel Stephen-Victor; Jagadeesh Bayry, Nature Clinical Practice Rheumatology, 2018

Multimerized IgG1 Fc molecule as an anti-inflammatory agent Multimerized IgG1 Fc molecule as an anti-inflammatory agent, Published online: 14 May 2018; doi:10.1038/s41584-018-0013-9 The success of intravenous immunoglobulin immunotherapy in autoimmune diseases has inspired the development of ...

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The role of radiography and MRI for eligibility assessment in DMOAD trials of knee OA

11-May-2018 | Frank W. Roemer; C. Kent Kwoh; Daichi Hayashi; David T. Felson; Ali Guermazi, Nature Clinical Practice Rheumatology, 2018

Currently, no disease-modifying osteoarthritis drugs (DMOADs) have been approved. Past clinical trials have failed for several reasons, including the commonly applied definition of eligibility based on radiographic assessment of joint structure. In the context of precision medicine, finding the ...

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Denosumab shows promise for GIOP

11-May-2018 | Sarah Onuora, Nature Clinical Practice Rheumatology, 2018

Denosumab shows promise for GIOP Denosumab shows promise for GIOP, Published online: 11 May 2018; doi:10.1038/s41584-018-0016-6 Denosumab shows promise for GIOP

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Axial disease in psoriatic arthritis and ankylosing spondylitis: a critical comparison

11-May-2018 | Joy Feld; Vinod Chandran; Nigil Haroon; Robert Inman; Dafna Gladman, Nature Clinical Practice Rheumatology, 2018

Ankylosing spondylitis (AS) was first identified in the late 17th century. 250 years later, inflammatory spine disease was recognized to be one of the patterns of psoriatic arthritis (PsA). Isolated spondylitis is rare among patients with PsA, occurring in less than 5% of patients; however, many ...

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