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1,897 Newest Publications in journal of medical virology

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Effectiveness and safety of original and generic sofosbuvir for the treatment of chronic hepatitis C: a real world study

19-Jan-2018 | Sebastián Marciano, Leila Haddad, María Virginia Reggiardo, Mirta Peralta, Cecilia Vistarini, Mónica Marino, Valeria ..., Journal of Medical Virology, 2018

Abstract We report the first real‐world prospective multicenter cohort study that evaluated the effectiveness and safety of original or generic sofosbuvir‐based regimens in patients with chronic hepatitis C in Latin America. The main endpoints were assessment of sustained virological response ...

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Hepatitis C virus core protein induces dysfunction of liver sinusoidal endothelial cell by down–regulation of silent information regulator 1

19-Jan-2018 | Li‐Jie Sun, Jian‐Wu Yu, Yu‐Guang Shi, Xiao‐Yu Zhang, Meng‐Ni Shu, Mo‐Yang Chen, Journal of Medical Virology, 2018

Abstract Objective Hepatic fibrosis is a frequent feature of chronic hepatitis C virus (HCV) infection. Some evidence has suggested the potential role of silent information regulator 1 (SIRT1) in organ fibrosis. The aim of this study was to investigate the effect of HCV core protein on ...

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Species differences in circulation and inflammatory responses in children with common respiratory adenovirus infections

19-Jan-2018 | Haruna Nakamura, Takao Fujisawa, Shigeru Suga, Kiyosu Taniguchi, Mizuho Nagao, Masahiro Ito, Hitoshi Ochiai, Masami ..., Journal of Medical Virology, 2018

Abstract Background: Human adenoviruses (HAdVs) cause severe inflammatory respiratory infections, but previous epidemiological studies lacked analysis of the characteristics of the inflammation. Methods: Consecutive patients Results: A total of 187 patients were enrolled, and HAdV types ...

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Misidentification of recombinant hepatitis C virus leading to treatment failure with direct acting antivirals

19-Jan-2018 | Thomas MOUREZ, Amandine DECROOS, Odile GORIA, Hélène MONTIALOUX, Fabienne OLIVEIRA, Sylvie LARRAT, Jean‐Christophe P ..., Journal of Medical Virology, 2018

Abstract The use of new Direct Acting Antivirals, specific of HCV, has greatly improved the HCV treatment. Most of the DAA are specific of HCV genotypes. Genotyping methods may target different regions of the HCV genome, though only the whole genome sequencing could confirm the correct ...

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Characteristics of patients with acute peripheral facial palsy showing Varicella zoster virus DNA in saliva

10-Jan-2018 | Dong Sik Chang, Jun Lee, Sun Ae Shin, Ho Yun Lee, Journal of Medical Virology, 2018

ABSTRACT Infection caused by Varicella zoster virus (VZV) is a common etiology of acute peripheral facial palsy (APFP). We aimed to assess the clinical significance of detecting VZV DNA from the saliva of patients with APFP. Saliva collected from thirty‐six patients with unilateral APFP at ...

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Surveillance for Antiviral Resistance among Influenza Viruses Circulating in Algeria during Five Consecutive Influenza Seasons (2009 to 2014)

09-Jan-2018 | Assia Ait Aissa, Fawzi Derrar, Djouher Hanoun, El Alia Gradi, Dino Scaravelli, Zihad Bouslama, Journal of Medical Virology, 2018

ABSTRACT Background: Influenza season 2007/2008 was marked by a worldwide emergence of oseltamivir‐resistant A(H1N1) viruses possessing a mutation in the neuraminidase gene causing His‐to‐Tyr substitution at amino acid position 275 (H275Y). These strains were isolated in Algeria where 30% of ...

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What is changed in HBV molecular epidemiology in Italy?

09-Jan-2018 | Alessia Lai, Caterina Sagnelli, Alessandra Lo Presti, Eleonora Cella, Silvia Angeletti, Silvia Spoto, Sebastiano Cos ..., Journal of Medical Virology, 2018

Abstract Hepatitis B virus (HBV) infection represents the most common cause of chronic liver diseases worldwide. Consequently, to the introduction of the universal HBV vaccination program, the prevalence of hepatitis B surface antigen was markedly reduced and less than 1% of the population of ...

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Very slow decline of hepatitis B virus surface antigen and core related antigen in chronic hepatitis B patients successfully treated with nucleos(t)ide analogues

09-Jan-2018 | EK Alidjinou, C Michel, V Canva, F Ajana, D Hober, L Bocket, Journal of Medical Virology, 2018

Abstract We investigated the decline of hepatitis B virus surface antigen (HBsAg) and core related antigen (HBcrAg) in chronic hepatitis B patients sussessfully treated with nucleos(t)ide analogues. In patients with plasma viral suppression, the baseline median levels of HBsAg and HBcrAg were ...

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Prognostic Value of Neutrophil‐to‐Lymphocyte Ratio Associated with Prognosis in HBV‐infected Patients

09-Jan-2018 | Jiao Gong, Yan‐Lan Liang, Wenying Zhou, Yusheng Jie, Cuicui Xiao, Yutian Chong, Bo Hu, Journal of Medical Virology, 2018

Abstract Chronic severe hepatitis B (CSHB) is a critical clinical syndrome with a high mortality rate in China. The prognostic value of neutrophil to lymphocyte ratio (NLR) which is simple, low‐cost, and useful inflammatory marker for hepatitis B virus (HBV)‐infected patients is largely ...

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Characterization of unusual DS‐1‐like G3P[8] rotavirus strains in children with diarrhea in Japan

09-Jan-2018 | Satoshi Komoto, Tomihiko Ide, Manami Negoro, Takaaki Tanaka, Kazutoyo Asada, Masakazu Umemoto, Haruo Kuroki, Hiroaki ..., Journal of Medical Virology, 2018

Abstract The emergence and rapid spread of novel DS‐1‐like intergenogroup reassortant rotaviruses having the equine‐like G3 genotype (DS‐1‐like G3P[8] strains) have been recently reported from several countries. During rotavirus surveillance in Japan in 2015‐2016, three DS‐1‐like G3P[8] ...

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