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1,040 Newest Publications in journal of applied toxicology

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Arsenite‐induced histone H3 modification and its effects on EGR1 and FOS expression in HeLa cells

19-Jan-2018 | Toshihide Suzuki, Hiroshi Watanabe, Kayoko Kita, Taro Honma, Takafumi Ochi, Journal of Applied Toxicology, 2018

Abstract It is evident that trivalent arsenicals do not have mutagenicity, but they are human carcinogens. Recently, epigenetic modification has been considered as one of the important causes of arsenical carcinogenicity. Here we examined global histone H3 modification by trivalent inorganic ...

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Multiple biological defects caused by calycosin‐7‐O‐β‐d‐glucoside in the nematode Caenorhabditis elegans are associated with the activation of oxidative damage

19-Jan-2018 | Jianqin Zhang, Xiaoli Xue, Yang Yang, Wen Ma, Yan Han, Xuemei Qin, Journal of Applied Toxicology, 2018

Abstract Calycosin‐7‐O‐β‐d‐glucoside (CG) is an important active isoflavone compound in Radix Astragali that has many bioactivities. However, the toxicological effects and related toxicological mechanism of CG have been rarely documented. The purpose of the present study was to evaluate the ...

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Multiple biological defects caused by calycosin‐7‐O‐β‐d‐glucoside in the nematode Caenorhabditis elegans are associated with the activation of oxidative damage

19-Jan-2018 | Jianqin Zhang, Xiaoli Xue, Yang Yang, Wen Ma, Yan Han, Xuemei Qin, Journal of Applied Toxicology, 2018

Abstract Calycosin‐7‐O‐β‐d‐glucoside (CG) is an important active isoflavone compound in Radix Astragali that has many bioactivities. However, the toxicological effects and related toxicological mechanism of CG have been rarely documented. The purpose of the present study was to evaluate the ...

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Effect of titanium dioxide nanoparticles on glucose homeostasis after oral administration

19-Jan-2018 | Zhangjian Chen, Yun Wang, Xiang Wang, Lin Zhuo, Shi Chen, Shichuan Tang, Lin Zhao, Xianguo Luan, Guang Jia, Journal of Applied Toxicology, 2018

Abstract As food additives, titanium dioxide nanoparticles (TiO2 NPs) have been widely used in various products that are usually simultaneously consumed with a high content of sugar, thus necessitating research on the effect of TiO2 NPs on glucose homeostasis. We conducted an animal study to ...

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Comparative RNA‐Seq transcriptome analysis on silica induced pulmonary inflammation and fibrosis in mice silicosis model

17-Jan-2018 | Jiayi Chen, Yuqin Yao, Xiaolan Su, Ying Shi, Xuejiao Song, Linshen Xie, Jia You, Liantian Tian, Luo Yang, Aiping Fan ..., Journal of Applied Toxicology, 2018

Abstract Silicosis is a long‐established public health issue in developing countries due to increasingly serious air pollution and poorly implemented occupational safety regulation. Inhalation of silica triggers cytotoxicity, oxidative stress, pulmonary inflammation and eventually silicosis. ...

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Increased risk of congestive heart failure in patients with acetaminophen poisoning: A nationwide cohort study

12-Jan-2018 | Wei-Sheng Chung, Cheng-Li Lin, Journal of Applied Toxicology, 2018

Abstract Acetaminophen poisoning increases cytochrome P450 2E1 expression and reactive oxygen species production, which may lead to maladaptive myocardial remodeling and congestive heart failure (CHF). We conducted a nationwide cohort study to investigate the incidence and risk of CHF in ...

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Binding affinity and decontamination of dermal decontamination gel to model chemical warfare agent simulants

08-Jan-2018 | Yachao Cao, Akram Elmahdy, Hanjiang Zhu, Xiaoying Hui, Howard Maibach, Journal of Applied Toxicology, 2018

Abstract Six chemical warfare agent simulants (trimethyl phosphate, dimethyl adipate, 2‐chloroethyl methyl sulfide, diethyl adipate, chloroethyl phenyl sulfide and diethyl sebacate) were studied in in vitro human skin to explore relationship between dermal penetration/absorption and the ...

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Involvement of the delayed rectifier outward potassium channel Kv2.1 in methamphetamine‐induced neuronal apoptosis via the p38 mitogen‐activated protein kinase signaling pathway

03-Jan-2018 | Jingying Zhu, Songsong Zang, Xufeng Chen, Lei Jiang, Aihua Gu, Jie Cheng, Li Zhang, Jun Wang, Hang Xiao, Journal of Applied Toxicology, 2018

Abstract Methamphetamine (Meth) is an illicit psychostimulant with high abuse potential and severe neurotoxicity. Recent studies have shown that dysfunctions in learning and memory induced by Meth may partially reveal the mechanisms of neuronal channelopathies. Kv2.1, the primary delayed ...

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Aryl hydrocarbon receptor‐based bioassays for dioxin detection: Thinking outside the box

26-Dec-2017 | Gaston Otarola, Hector Castillo, Sylvain Marcellini, Journal of Applied Toxicology, 2017

Abstract Despite intensive media coverage and international regulations, man‐made persistent organic pollutants such as dioxins represent a serious environmental and health threat. Their detection by sophisticated chromatography technologies is highly complex, impeding the constant monitoring ...

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Issue Information

20-Oct-2017 | Journal of Applied Toxicology, 2017

No abstract is available for this article.

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