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186 Newest Publications in genes and immunity

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IFN-λs inhibit Hantaan virus infection through the JAK-STAT pathway and expression of Mx2 protein

15-May-2018 | Ning Li; Fan Luo; Qingzhou Chen; Ni Zhu; Hui Wang; Linlin Xie; Hairong Xiong; Ming Yue; Yun Zhang; Yong Feng; Wei Hou, Genes and Immunity, 2018

Hantaan virus (HTNV), member of the newly defined Hantaviridae family, within the order Bunyavirales, can cause a hemorrhagic fever with renal syndrome with high fatality rates in humans. However, no specific antiviral agents are currently available for HTNV infection approved by the US Food and ...

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IKKα deficiency disrupts the development of marginal zone and follicular B cells

08-May-2018 | Mumtaz Y. Balkhi; Jami Willette-Brown; Gabor Wittmann; Yinling Hu, Genes and Immunity, 2018

Only few genes have been confidently identified to be involved in the Follicular (FO) and Marginal Zone (MZ) B cell differentiation, migration, and retention in the periphery. Our group previously observed that IKKα kinase inactive mutant mice IKKα K44A/K44A have ...

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Citrobacter rodentium alters the mouse colonic miRNome

01-May-2018 | Bijun Wen; Tomas Tokar; Amel Taibi; Jianmin Chen; Igor Jurisica; Elena M. Comelli, Genes and Immunity, 2018

Citrobacter rodentium is a murine pathogen causing transmissible colonic hyperplasia and colitis with a pathogenic mechanism similar to foodborne enterohaemorrhagic Escherichia coli in humans. Mechanisms underlying intestinal responses to C. rodentium infection are incompletely understood. We ...

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Mutations in RNA Polymerase III genes and defective DNA sensing in adults with varicella-zoster virus CNS infection

01-May-2018 | Madalina E. Carter-Timofte; Anders F. Hansen; Mette Christiansen; Søren R. Paludan; Trine H. Mogensen, Genes and Immunity, 2018

Recently, deficiency in the cytosolic DNA sensor RNA Polymerase III was described in children with severe primary varicella-zoster virus (VZV) infection in the CNS and lungs. In the present study we examined adult patients with VZV CNS infection caused by viral reactivation. By whole exome ...

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Evaluation of the TLR negative regulatory network in CVID patients

05-Apr-2018 | Roozbeh Sanaei; Nima Rezaei; Asghar Aghamohammadi; Ali-Akbar Delbandi; Shahram Teimourian; Reza Yazdani; Parsova Tav ..., Genes and Immunity, 2018

Common variable immunodeficiency (CVID), a clinically symptomatic primary immunodeficiency disease (PID), is characterized by hypogammaglobulinemia leading to recurrent infections and various complications. Recently, some defects in the signaling of TLRs have been identified in CVID patients ...

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Population genetic evidence for positive and purifying selection acting at the human IFN-γ locus in Africa

29-Mar-2018 | Michael C. Campbell; Lunden T. Smith; Jayla Harvey, Genes and Immunity, 2018

Despite its critical role in the defense against microbial infection and tumor development, little is known about the range of nucleotide and haplotype variation at IFN-γ, or the evolutionary forces that have shaped patterns of diversity at this locus. To address this gap in knowledge, we ...

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Population genetic evidence for positive and purifying selection acting at the human IFN-γ locus in Africa

29-Mar-2018 | Michael C. Campbell; Lunden T. Smith; Jayla Harvey, Genes and Immunity, 2018

Despite its critical role in the defense against microbial infection and tumor development, little is known about the range of nucleotide and haplotype variation at IFN-γ, or the evolutionary forces that have shaped patterns of diversity at this locus. To address this gap in knowledge, we ...

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Genetic variants and pathways implicated in a pediatric inflammatory bowel disease cohort

28-Mar-2018 | Kelly A. Shaw; David J. Cutler; David Okou; Anne Dodd; Bruce J. Aronow; Yael Haberman; Christine Stevens; Thomas D. ..., Genes and Immunity, 2018

In the United States, approximately 5% of individuals with inflammatory bowel disease (IBD) are younger than 20 years old. Studies of pediatric cohorts can provide unique insights into genetic architecture of IBD, which includes Crohn’s disease (CD) and ulcerative colitis (UC). Large genome-wide ...

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Akkermansia muciniphila is permissive to arthritis in the K/BxN mouse model of arthritis

24-Mar-2018 | Matthew L Stoll; M Kathy Pierce; Jordan A Watkins; Mingce Zhang; Pamela F Weiss; Jennifer E Weiss; Charles O Elson; ..., Genes and Immunity, 2018

Studies have identified abnormalities in the microbiota of patients with arthritis. To evaluate the pathogenicity of human microbiota, we performed fecal microbial transplantation from children with spondyloarthritis and controls to germ-free KRN/B6xNOD mice. Ankle swelling was equivalent in ...

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Association between interleukin family gene polymorphisms and recurrent aphthous stomatitis risk

18-Mar-2018 | Jun Wu; Wei Wang, Genes and Immunity, 2018

The present study was aimed at identifying the association between interleukin family gene polymorphisms and recurrent aphthous stomatitis (RAS) risk using a meta-analysis. We searched the PubMed, web of science, Embase and ScienceDirect-Elsevier databases for research on the interleukin ...

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