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589 Newest Publications in fundamental & clinical pharmacology


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Anti‐inflammatory effect of 4‐methylcyclopentadecanonein rats submitted to ischemic stroke

18-Jan-2018 | Yan Jin, Fang Wei, Xiaoli Dai, Min Qi, Yukui Ma, Fundamental & Clinical Pharmacology, 2018

Abstract The present study aimed to investigate the anti‐inflammatory effect of 4‐methylcyclopentadecanone (4‐MCPC) in rats suffering from a cerebral ischemia/ reperfusion (I/R) injury. In this study, the focal cerebral ischemia in rats was induced by middle cerebral artery occlusion (MCAO) ...


Aging and hypertension decrease endothelial NO‐related dilating function and gamma‐glutamyltransferase activity but not S‐nitrosoglutathione‐induced aortic vasodilation

16-Jan-2018 | Caroline Perrin‐Sarrado, Fatima Dahboul, Pierre Leroy, Isabelle Lartaud, Fundamental & Clinical Pharmacology, 2018

Abstract S‐nitrosoglutathione (GSNO), which is involved in the transport and the storage of NO, induces vasorelaxation. It requires gamma‐glutamyl‐transferase (GGT), an enzyme present on the endothelium, to transfer NO into the cell. We evaluated whether aging and hypertension, which induce ...


Impact of pregnancy on psychoactive substance use among women with substance use disorders recruited in addiction specialized care centers in France

16-Jan-2018 | Liselotte Pochard, Julie Dupouy, Elisabeth Frauger, Adeline Giocanti, Joëlle Micallef, Maryse Lapeyre‐Mestre,, Fundamental & Clinical Pharmacology, 2018

Abstract Pregnancy can be a motivation for decrease in drug abusing but may also represent a period of high vulnerability for relapse.We aimed to assess psychoactive substance use among women with substance use disorders followed in addiction care centers in France. We analyzed data from ...


Possible role of CYP2B6 genetic polymorphisms in ifosfamide‐induced encephalopathy: report of three cases

10-Jan-2018 | Thomas Duflot, Aude Marie‐Cardine, Céline Verstuyft, Bruno Filhon, Tony Pereira, Nathalie Massy Guillemant, Robinson ..., Fundamental & Clinical Pharmacology, 2018

Abstract Ifosfamide (IFA) is a potent alkylating antitumoral agent but its use is limited by neurological side effects. IFA is a racemic mixture of two enantiomeric forms, R‐IFA and S‐IFA with a stereoselective metabolism by CYP3A4 and CYP2B6, leading either to bioactive or to toxic pathways. ...


Continuous intravenous vancomycin in children with normal renal function hospitalized in hematology‐oncology: prospective validation of a dosing regimen optimizing steady‐state concentration

06-Jan-2018 | Delphine Hoegy, Sylvain Goutelle, Nathalie Garnier, Cécile Rénard, Cécile Faure‐Conter, Christophe Bergeron, Yves Be ..., Fundamental & Clinical Pharmacology, 2018

Abstract Continuous intravenous (IV) infusion has been shown to be the best option to administer vancomycin because of its time‐dependent bactericidal activity. Available IV vancomycin dosing guidelines in pediatrics with normal renal function leads to less than 50% of patients achieving a ...


Visualization of temporal patterns in patient record data

17-Oct-2017 | Catherine Plaisant, Fundamental & Clinical Pharmacology, 2017

Abstract Visualization contributes to a variety of tasks, from reviewing individual patient records to helping researchers assess data quality, find patients of interest, review temporal patterns and anomalies or understand differences between cohorts. We review some of visualization ...


Atropinic (Anticholinergic) Burden in Antipsychotic‐Treated Patients

09-Sep-2017 | François Montastruc, Justine Benevent, Anthony Touafchia, Leila Chebane, Mélanie Araujo, Emmanuelle Guitton‐Bondon, ..., Fundamental & Clinical Pharmacology, 2017

Abstract Antipsychotic drugs possess side atropinic (anticholinergic) properties that may induce several adverse drug reactions (ADRs), such as memory loss or cognitive impairment. The aim of the present study was investigating anticholinergic burden in patients treated with antipsychotic ...


Rationale and design of the CANARI study: a case‐control study investigating the association between prostate cancer and 5 alpha‐reductase inhibitors for symptomatic benign prostate hypertrophy by linking SNIIRAM and pathology laboratories in a specific region in France

30-Aug-2017 | Lucie‐Marie Scailteux, Frédéric Balusson, Sébastien Vincendeau, Nathalie Rioux‐Leclercq, Emmanuel Nowak, Fundamental & Clinical Pharmacology, 2017

Abstract Benign prostate hypertrophy (BPH) could be associated with low urinary symptoms requiring medical treatment: 5 alpha‐reductase inhibitors (5‐ARI) or ɑ‐blockers. Two clinical trials investigating 5‐ARI use in prostate cancer (PCa) primary prevention highlighted a potential safety ...


Average Spectral Power Changes at the Hippocampal Electroencephalogram in Schizophrenia Model Induced by Ketamine

29-Aug-2017 | Luis Rafael L. Sampaio, Lucas T.N. Borges, Joyse M.F. Silva, Francisca Roselin O. de Andrade, Talita M. Barbosa, Tat ..., Fundamental & Clinical Pharmacology, 2017

Abstract The use of ketamine (Ket) as a pharmacological model of schizophrenia is an important tool for understanding the main mechanisms of glutamatergic regulated neural oscillations. Thus, the aim of the current study was to evaluate Ket induced changes in the average spectral power using ...


Angiotensin converting enzyme 2‐Angiotensin 1‐7/1‐9 system: novel promising targets for heart failure treatment

21-Aug-2017 | Naim Kittana, Fundamental & Clinical Pharmacology, 2017

Abstract Cardiac remodeling (cardiac hypertrophy and fibrosis) is a hall mark of heart failure (HF). It can be induced by the abnormal elevation of several endogenous factors including angiotensin II (Ang II), which is generated from its precursor angiotensin I (Ang I) by the action of ...


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