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1,526 Newest Publications in clinical microbiology and infection

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Polymerase‐chain reaction/electrospray ionization‐mass spectrometry for the detection of bacteria and fungi in bronchoalveolar lavage fluids: a prospective observational study

20-Dec-2014 | A. Huttner, S. Emonet, S. Harbarth, G. Renzi, L. Kaiser, J. Schrenzel, Clinical Microbiology and Infection, 2014

Abstract PLEX‐ID uses polymerase chain reaction‐electrospray ionization/mass spectrometry for rapid identification of infectious agents in clinical samples. We evaluated its concordance with our centre's standard methods (SM) for bacterial and fungal detection in bronchoalveolar lavage (BAL) ...

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HIV infection en route to endogenization: two cases

04-Nov-2014 | Philippe Colson, Isabelle Ravaux, Catherine Tamalet, Olga Glazunova, Emeline Baptiste, Eric Chabriere, Aurélie Wiede ..., Clinical Microbiology and Infection, 2014

Abstract The long‐term spontaneous evolution between humans and the human immunodeficiency virus (HIV) is not well characterized; many species, including humans, exhibit remnants of other retroviruses in their genomes that question such possible endogenization of HIV. We investigated two ...

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From “purging” to “endogenization” of the HIV genome: a new approach to HIV eradication?

04-Nov-2014 | Guido Antonelli, Clinical Microbiology and Infection, 2014

The development of antiretroviral therapy (ART) for the treatment of human immunodeficiency virus (HIV) infection represents one of the greatest achievements of modern medicine. ART has significantly changed the clinical outcome of HIV‐infected individuals, the rates of HIV‐related ...

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Cost‐effectiveness analysis of treatment strategies for initial Clostridium difficile infection

04-Nov-2014 | Raghu U. Varier, Eman Biltaji, Kenneth J Smith, Mark S. Roberts, M. Kyle Jensen, Joanne LaFleur, Richard E Nelson, Clinical Microbiology and Infection, 2014

Background Clostridium difficile infection (CDI) is costly. Current guidelines recommend metronidazole as first‐line therapy, and vancomycin as an alternative. Recurrence is common. Fecal microbiota transplantation (FMT) is an effective therapy for recurrent CDI (RCDI). This study explores the ...

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Host factors and genetic susceptibility for infections due to intracellular bacteria and fastidious organisms

04-Nov-2014 | S. A. Asner, S.A. Morré, Pierre‐Yves Bochud, G. Greub, Clinical Microbiology and Infection, 2014

Abstract While genetic polymorphisms play a paramount role in tuberculosis (TB), less is known about their contribution to the severity of diseases caused by other intracellular bacteria and fastidious microorganisms. We searched electronic databases for observational studies reporting on ...

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Early carbapenem‐resistant Klebsiella pneumoniae bacteraemia: should we expand the screening?

04-Nov-2014 | Daniele Roberto Giacobbe, Valerio Del Bono, Anna Marchese, Claudio Viscoli, Clinical Microbiology and Infection, 2014

We would like to add some comments to the paper “Detection of carbapenemases in Enterobacteriaceae: a challenge for diagnostic microbiological laboratories” by Hrabák J etal., which provides an exhaustive review of the state of the art in laboratory detection of carbapenemase‐producing ...

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Does it make sense to detect Streptococcus pyogenes during tonsillitis in Europe to prevent acute rheumatic fever?

08-Oct-2014 | Sophie Edouard, Audrey Michel‐Lepage, Didier Raoult, Clinical Microbiology and Infection, 2014

French health authorities constantly publish public health recommendations, and ever since the pay‐for‐performance (P4P) program was implemented in France, physicians have been more motivated to follow them [1]. Currently, guidelines regarding pharyngeal infection, one of the most common ...

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Success stories of implementation of antimicrobial stewardship: a narrative review

08-Oct-2014 | Benedikt Huttner, Stephan Harbarth, Dilip Nathwani,, Clinical Microbiology and Infection, 2014

Abstract It has been increasingly recognized that antimicrobial stewardship (AMS) has to be a key component of any efforts that aim to mitigate the current global antimicrobial resistance (AMR) crisis. It has also become evident that AMR is a problem that cannot be tackled by single ...

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Host genetics and opportunistic fungal infections

01-Oct-2014 | Zoe‐Dorothea Pana, Evangelia Farmaki, Emmanuel Roilides, Clinical Microbiology and Infection, 2014

Abstract Current knowledge on the human pathophysiology of fungal infections highlights the crucial role of genetic pitfalls in specific immunity pathways that determine together with other risk factors predisposition to and clinical outcome of fungal disease. In several studies associations ...

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Fecal microbiota transplantation – the Austrian approach

01-Oct-2014 | Patrizia K. Kump, Robert Krause, Franz Allerberger, Christoph Högenauer, Clinical Microbiology and Infection, 2014

Abstract The intestinal microbiome is essential for maintaining human health and defending against intestinal pathogens. Alterations of the intestinal microbiota, also termed dysbiosis, play a pivotal role in the pathogenesis of various human diseases. Fecal microbiota transplantation (FMT) ...

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