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797 Newest Publications in acta biochimica et biophysica sinica

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Photothermal treatment with EGFRmAb–AuNPs induces apoptosis in hypopharyngeal carcinoma cells via PI3K/AKT/mTOR and DNA damage response pathways

27-Apr-2018 | Zhang Y, Cong L, He J, et al., Acta Biochimica et Biophysica Sinica, 2018

Abstract Hypopharyngeal carcinoma (HC) is one of the most malignant tumors in the upper aerodigestive tract. Currently, there are no effective treatments for HC. Gold nanoparticles (AuNPs) are a promising tool that can be used for plasmonic photothermal therapy (PPTT), which refers to the use of ...

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The inhibitory effect of BKCa channels induced by autoantibodies against angiotensin II type 1 receptor is independent of AT1R

25-Apr-2018 | Wang P, Zhang S, Ren J, et al., Acta Biochimica et Biophysica Sinica, 2018

Abstract Autoantibodies against angiotensin II Type 1 receptor (AT1-AA) are routinely detected in the serum of preeclampsia patients, which results in an increase in vascular tone and an elevation in intracellular calcium concentration of rat vascular smooth muscle (VSM). The big conductance ...

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Effects of ovarian hormone loss on neuritic plaques and autophagic flux in the brains of adult female APP/PS1 double-transgenic mice

29-Mar-2018 | Yao Q, Feng M, Yang B, et al., Acta Biochimica et Biophysica Sinica, 2018

Abstract Epidemiologic studies have demonstrated that women account for two-thirds of Alzheimer’s disease (AD) cases, for which the decline in circulating gonadal hormone is considered to be one of the major risk factors. In addition, ovarian hormone deficiency may affect β-amyloid (Aβ) ...

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Transcriptome profiling of genes involving in carotenoid biosynthesis and accumulation between leaf and root of carrot (Daucus carota L.)

29-Mar-2018 | Ma J, Li J, Xu Z, et al., Acta Biochimica et Biophysica Sinica, 2018

Abstract Carrot provides abundant carotenoid for human diet and is one of the most widely cultivated root vegetables in the world. However, the absence of the tissue-specific transcriptome of carrots hampers the investigation of the association of secondary metabolic mechanism with the different ...

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Molecular regulation of Nodal signaling during mesendoderm formation

01-Dec-2017 | Wei S, Wang Q., Acta Biochimica et Biophysica Sinica, 2017

Abstract One of the most important events during vertebrate embryogenesis is the formation or specification of the three germ layers, endoderm, mesoderm, and ectoderm. After a series of rapid cleavages, embryos form the mesendoderm and ectoderm during late blastulation and early gastrulation. The ...

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TGF-β signaling in cancer metastasis

28-Nov-2017 | Xie F, Ling L, van Dam H, et al., Acta Biochimica et Biophysica Sinica, 2017

Abstract The transforming growth factor (TGF)-β signaling events are well known to control diverse processes and numerous responses, such as cell proliferation, differentiation, apoptosis, and migration. TGF-β signaling plays context-dependent roles in cancer: in pre-malignant cells TGF-β ...

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TGF-β signaling pathway in early mouse development and embryonic stem cells

28-Nov-2017 | Liu C, Peng G, Jing N., Acta Biochimica et Biophysica Sinica, 2017

Abstract TGF-β superfamily signaling pathways essentially contribute to the broad spectrum of early developmental events including embryonic patterning, cell fate determination and dynamic movements. In this review, we first introduced some key developmental processes that require TGF-β signaling ...

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The role of TGF-β superfamily signaling in neurological disorders

28-Nov-2017 | Kashima R, Hata A., Acta Biochimica et Biophysica Sinica, 2017

Abstract The TGF-β superfamily signaling is involved in a variety of biological processes during embryogenesis and in adult tissue homeostasis. Faulty regulation of the signaling pathway that transduces the TGF-β superfamily signals accordingly leads to a number of ailments, such as cancer and ...

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Intracellular trafficking of transforming growth factor β receptors

25-Nov-2017 | Yakymovych I, Yakymovych M, Heldin C., Acta Biochimica et Biophysica Sinica, 2017

Abstract Transforming growth factor β (TGFβ) family members signal via heterotetrameric complexes of type I (TβRI) and type II (TβRII) dual specificity kinase receptors. The availability of the receptors on the cell surface is controlled by several mechanisms. Newly synthesized TβRI and TβRII are ...

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Smad3–STAT3 crosstalk in pathophysiological contexts

13-Nov-2017 | Itoh Y, Saitoh M, Miyazawa K., Acta Biochimica et Biophysica Sinica, 2017

Abstract Smad3 and STAT3 are intracellular molecules that transmit signals from plasma membrane receptors to the nucleus. Smad3 operates downstream of growth/differentiation factors that utilize activin receptor-like kinase (ALK)-4, 5, or 7, such as transforming growth factor-β (TGF-β), activin, ...

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