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1,853 Newest Publications in acs chemical biology

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Establishment of LCMS Based Platform for Discovery of Quorum Sensing Inhibitors: Signal Detection in Pseudomonas aeruginosa PAO1

18-Jan-2018 | Manoj Kushwaha; Shreyans K. Jain; Nisha Sharma; Vidushi Abrol; Sundeep Jaglan; Ram A. Vishwakarma, ACS Chemical Biology, 2018

Targeting the main three networking systems, viz. Las, RhI, and PQS, via natural quenchers is a new ray of hope for combating the persistent behavior of Pseudomonas aeruginosa. In the bacterial chemical vocabulary pyocyanin, N-AHLs and rhamnolipids are the main keywords, which are responsible for ...

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Dual Allosteric Inhibition of SHP2 Phosphatase

18-Jan-2018 | Michelle Fodor; Edmund Price; Ping Wang; Hengyu Lu; Andreea Argintaru; Zhouliang Chen; Meir Glick; Huai-Xiang Hao; M ..., ACS Chemical Biology, 2018

SHP2 is a cytoplasmic protein tyrosine phosphatase encoded by the PTPN11 gene and is involved in cell proliferation, differentiation, and survival. Recently, we reported an allosteric mechanism of inhibition that stabilizes the auto-inhibited conformation of SHP2. SHP099 (1) was identified and ...

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Chemical Control of a CRISPR-Cas9 Acetyltransferase

17-Jan-2018 | Jonathan H. Shrimp; Carissa Grose; Stephanie R. T. Widmeyer; Abigail L. Thorpe; Ajit Jadhav; Jordan L. Meier, ACS Chemical Biology, 2018

Lysine acetyltransferases (KATs) play a critical role in the regulation of transcription and other genomic functions. However, a persistent challenge is the development of assays capable of defining KAT activity directly in living cells. Toward this goal, here we report the application of a ...

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Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity

17-Jan-2018 | Franziska Kundel; Suman De; Patrick Flagmeier; Mathew H. Horrocks; Magnus Kjaergaard; Sarah L. Shammas; Sophie E. Ja ..., ACS Chemical Biology, 2018

As a key player of the protein quality control network of the cell, the molecular chaperone Hsp70 inhibits the aggregation of the amyloid protein tau. To date, the mechanism of this inhibition and the tau species targeted by Hsp70 remain unknown. This is partly due to the inherent difficulty of ...

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Protein Inhibitors of CRISPR-Cas9

17-Jan-2018 | Joseph Bondy-Denomy, ACS Chemical Biology, 2018

Bacteria are under constant predation from viruses, called bacteriophages (phages). This threat has driven the evolution of multiple defense systems, including the CRISPR-Cas (clustered regularly interspaced short palindromic repeats and CRISPR associated genes) immune pathway. Phages are not ...

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Oxidatively Generated Lesions as Internal Photosensitizers for Pyrimidine Dimerization in DNA

17-Jan-2018 | Isabel Aparici-Espert; Guillermo Garcia-Lainez; Inmaculada Andreu; Miguel Angel Miranda; Virginie Lhiaubet-Vallet, ACS Chemical Biology, 2018

In this work, the attention is focused on UVA-photosensitized reactions triggered by a DNA chromophore-containing lesion, namely 5-formyluracil. This is a major oxidatively generated lesion that exhibits an enhanced light absorption in the UVB–UVA region. The mechanistic study combining ...

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Generation of Optogenetically Modified Adenovirus Vector for Spatiotemporally Controllable Gene Therapy

12-Jan-2018 | Kazuo Takayama; Hiroyuki Mizuguchi, ACS Chemical Biology, 2018

Gene therapy is expected to be utilized for the treatment of various diseases. However, the spatiotemporal resolution of current gene therapy technology is not high enough. In this study, we generated a new technology for spatiotemporally controllable gene therapy. We introduced optogenetic and ...

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Investigation of Amide Bond Formation during Dehydrophos Biosynthesis

12-Jan-2018 | Emily C. Ulrich; Despina J. Bougioukou; Wilfred A. van der Donk, ACS Chemical Biology, 2018

Dehydrophos is a tripeptide phosphonate antibiotic produced by Streptomyces luridus. Its biosynthetic pathway involves the use of aminoacyl-tRNA (aa-tRNA) for amide bond formation. The first amide bond during biosynthesis is formed by DhpH-C, a peptidyltransferase that utilizes Leu-tRNALeu. ...

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Development of Stabilized Peptide-Based PROTACs against Estrogen Receptor α

11-Jan-2018 | Yanhong Jiang; Qiwen Deng; Hui Zhao; Mingsheng Xie; Longjian Chen; Feng Yin; Xuan Qin; Weihao Zheng; Yongjuan Zhao; ..., ACS Chemical Biology, 2018

Peptide modulators targeting protein–protein interactions (PPIs) exhibit greater potential than small-molecule drugs in several important aspects including facile modification and relative large contact surface area. Stabilized peptides constructed by variable chemistry methods exhibit improved ...

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Live Cell Visualization of Multiple Protein–Protein Interactions with BiFC Rainbow

11-Jan-2018 | Sheng Wang; Miao Ding; Boxin Xue; Yingping Hou; Yujie Sun, ACS Chemical Biology, 2018

As one of the most powerful tools to visualize PPIs in living cells, bimolecular fluorescence complementation (BiFC) has gained great advancement during recent years, including deep tissue imaging with far-red or near-infrared fluorescent proteins or super-resolution imaging with photochromic ...

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