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Molecular dynamic study of TMPA mediated dissociation of Nur77-LKB1 complex

01-Jul-2018 | Author(s): Ikrormi Rungsung, Muthukumaran Rajagopalan, Amutha Ramaswamy, Computational Biology and Chemistry, 2018

Publication date: Available online 30 June 2018 Source:Computational Biology and Chemistry Author(s): Ikrormi Rungsung, Muthukumaran Rajagopalan, Amutha Ramaswamy LKB1 protein is involved in the regulation of cell polarity by phosphorylating the AMPK under energetic stress conditions. ...

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Pharmacokinetics of pericyte involvement in small-molecular drug transport across the blood-brain barrier

01-Jul-2018 | Author(s): Nebojsa Mihajlica, Christer Betsholtz, Margareta Hammarlund-Udenaes, European Journal of Pharmaceutical Science, 2018

Publication date: 15 September 2018 Source:European Journal of Pharmaceutical Sciences, Volume 122 Author(s): Nebojsa Mihajlica, Christer Betsholtz, Margareta Hammarlund-Udenaes Pericytes are perivascular cells that play important roles in the regulation of the blood-brain barrier ...

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Microstructural characterization of papaverine-loaded HPC/PVA gels, films and nanofibers

01-Jul-2018 | Author(s): Adrienn Kazsoki, Attila Domján, Károly Süvegh, Romána Zelkó, European Journal of Pharmaceutical Science, 2018

Publication date: 15 September 2018 Source:European Journal of Pharmaceutical Sciences, Volume 122 Author(s): Adrienn Kazsoki, Attila Domján, Károly Süvegh, Romána Zelkó Papaverine hydrochloride loaded gels, films and electrospun fibers were prepared for buccal drug delivery with ...

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Optimization of nanostructured lipid carriers for Zidovudine delivery using a microwave-assisted production method

01-Jul-2018 | Author(s): S.M.T. Cavalcanti, C. Nunes, S.A. Costa Lima, J.L. Soares-Sobrinho, S. Reis, European Journal of Pharmaceutical Science, 2018

Publication date: 15 September 2018 Source:European Journal of Pharmaceutical Sciences, Volume 122 Author(s): S.M.T. Cavalcanti, C. Nunes, S.A. Costa Lima, J.L. Soares-Sobrinho, S. Reis An adapted methodology for obtaining lipid nanoparticles that only uses the microwave reactor ...

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Spared perception of object geometry and object components after hippocampal damage [BRIEF COMMUNICATIONS]

01-Jul-2018 | Zhisen J. Urgolites; Daniel A. Levy; Ramona O. Hopkins; Larry R. Squire, Learning & Memory, 2018

We tested the proposal that medial temporal lobe (MTL) structures support not just memory but also high-level object perception. In one task, participants decided whether a line drawing could represent an object in three-dimensional space and, in another task, they saw the components of an object ...

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Cued fear memory generalization increases over time [RESEARCH]

01-Jul-2018 | Gabrielle A. Pollack; Jessica L. Bezek; Serena H. Lee; Miranda J. Scarlata; Leah T. Weingast; Hadley C. Bergstrom, Learning & Memory, 2018

Fear memory is a highly stable and durable form of memory, even over vast (remote) time frames. Nevertheless, some elements of fear memory can be forgotten, resulting in generalization. The purpose of this study is to determine how cued fear memory generalizes over time and measure underlying ...

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Properties of visual episodic memory following repeated encounters with objects [RESEARCH]

01-Jul-2018 | Mark W. Schurgin; Jonathan I. Flombaum, Learning & Memory, 2018

A person sees an object once, and then seconds, minutes, hours, days, or weeks later, she sees it again. How is the person's visual memory for that object changed, improved, or degraded by the second encounter, compared to a situation in which she will have only seen the object once? The answer ...

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T-type calcium channels in the orbitofrontal cortex mediate sensory integration as measured using a spontaneous oddity task in rats [RESEARCH]

01-Jul-2018 | Wendie N. Marks; Madeline E. Parker; Nadine K. Zabder; Quentin Greba; Terrance P. Snutch; John G. Howland, Learning & Memory, 2018

The roles of low-voltage-activated (T-type) calcium channels in brain diseases have been studied extensively. Less is known regarding the involvement of T-type channels in cognition and behavior. Sensory integration (SI) is a cognitive process whereby the brain uses unimodal or multimodal sensory ...

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Differential development of retroactive and proactive interference during post-learning wakefulness [BRIEF COMMUNICATIONS]

01-Jul-2018 | Timothy P. Brawn; Howard C. Nusbaum; Daniel Margoliash, Learning & Memory, 2018

Newly encoded, labile memories are prone to disruption during post-learning wakefulness. Here we examine the contributions of retroactive and proactive interference to daytime forgetting on an auditory classification task in a songbird. While both types of interference impair performance, they do ...

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Role of the novel endoribonuclease SLFN14 and its disease-causing mutations in ribosomal degradation [ARTICLE]

01-Jul-2018 | Sarah J. Fletcher; Vera P. Pisareva; Abdullah O. Khan; Andrew Tcherepanov; Neil V. Morgan; Andrey V. Pisarev, RNA, 2018

Platelets are anucleate and mostly ribosome-free cells within the bloodstream, derived from megakaryocytes within bone marrow and crucial for cessation of bleeding at sites of injury. Inherited thrombocytopenias are a group of disorders characterized by a low platelet count and are frequently ...

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